Search results for " tecniche"
showing 10 items of 317 documents
Alcune osservazioni sugli Enti (pubblici) di ricerca: il loro ruolo e brevi cronache di una devastazione annunciata.
2011
Verranno presentate alcune considerazioni sul ruolo che gli Enti di ricerca dovrebbero (e potrebbero) svolgere nel complesso sistema dell’alta formazione e di quello che ad essa è connesso (dallo sviluppo produttivo al vivere civile). La motivazione di fondo, poi, delle considerazioni che seguono è che la ricerca scientifica può svolgere un ruolo cruciale in tutti questi aspetti in quanto essa è connessa in modo essenziale all’uso di un metodo critico che fa discendere le conclusioni cui essa arriva dalle argomentazioni addotte e non dall’autorità di qualcuno.
The three facets of the SARS-CoV-2 pandemic during the first two waves in the northern, central, and southern Italy
2023
Background: There is a scarcity of information in literature regarding the clinical differences and comorbidities of patients affected by Coronavirus disease 2019 (COVID-19), which could clarify the different prevalence of the outcomes (composite and only death) between several Italian regions. Objective: This study aimed to assess the heterogeneity of clinical features of patients with COVID-19 upon hospital admission and disease outcomes in the northern, central, and southern Italian regions. Methods: An observational cohort multicenter retrospective study including 1210 patients who were admitted for COVID-19 in Infectious diseases, Pulmonology, Endocrinology, Geriatrics and Internal Med…
Tecniche costruttive antisismiche in Calabria tra la fine dell'Ottocento e l'inizio del Novecento,
2016
La presente memoria intende indagare lo sviluppo delle costruzioni antisismiche in Calabria in un periodo compreso tra gli anni Ottanta dell'Ottocento e i primi anni del Novecento. Lo studio è incentrato sulle tecniche costruttive adottate nelle ricostruzioni post-terremoto realizzate in un periodo immediatamente antecedente il sisma che colpì Messina e Reggio Calabria nel 1908, dopo il quale si registra un progressiva affermazione della tecnologia del cemento armato. In questo arco cronologico si assiste a un notevole sviluppo degli studi nel campo della costruzione antisismica, con una prevalente riproposizione di sistemi costruttivi tradizionali e con le prime sperimentazioni sul cemento…
SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α
2015
AbstractCeramide regulates several different cellular responses including mechanisms leading to apoptosis. Serum- and glucocorticoid-inducible protein kinase (SGK)-1 is a serine threonine kinase, which activates survival pathways in response to stress stimuli. Recently, we demonstrated an anti-apoptotic role of SGK-1 in human umbilical endothelial cells treated with high glucose. In the present study, since ceramide induces apoptosis by multiple mechanisms in diabetes and its complication such as nephropathy, we aimed to investigate whether SGK-1 may protect even against apoptosis induced by ceramide in kidney cells. Human embryonic kidney (HEK)-293 cells stable transfected with SGK-1 wild …
Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids
2021
AbstractThe prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination, which are sustained by the cancer stem cell (CSC) population. The main driver of the CSC gene expression program is Wnt signaling, and previous reports indicate that Wnt3a can activate p38 MAPK. Besides, p38 was shown to feed into the canonical Wnt/β-catenin pathway. Here we show that patient-derived locally advanced CRC stem cells (CRC-SCs) are characterized by increased expression of p38α and are “addicted” to its kinase activity. Of note, we found that stage III CRC patients with high p38α levels display…
Transbuccal tablets of carbamazepine: formulation, release and absorption pattern.
2006
Tranbsuccal drug administration is an attractive method, as it has several advantages especially with respect to peroral delivery. Here we report: i) the aptitude of carbamazepine (CBZ) to penetrate porcine buccal mucosa and reconstituted human oral (RHO) epithelium; ii) three different tablet formulations for transbuccal administration; iii) the drug release rate from tablets. CBZ permeation through the buccal mucosa was investigated by using two different bi-compartmental open models: Franz cells for porcine buccal mucosa and Transwell diffusion cells system for RHO epithelium. Results, expressed as drug flux (Js) and permeability coefficients (Kp), indicated that CBZ well penetrates the …
Renal function and carotid atherosclerosis in adults with no known kidney disease
2017
Abstract Background and aims A high prevalence of atherosclerotic lesions characterizes patients with chronic kidney disease, though there is little data on the relationship between kidney function and atherosclerotic changes in the healthy population or in people with no known renal impairment. The aim of our study was to analyze, in a comprehensive general population with no known kidney disease, the relationship between renal function and subclinical carotid atherosclerotic damage. Methods and results A general real-life population of 611 participants (233 males and 378 females; age ≥18 years) with no known kidney failure was selected for the study. The glomerular filtration rate (GFR) w…
Habitual street food intake and subclinical carotid atherosclerosis.
2013
Street food (SF) is defined as out-of-home food consumption, and generally consists of energy-dense meals rich in saturated fats and poor in fibers, vitamins and antioxidants. Though SF consumption may have unfavorable metabolic and cardiovascular effects, its possible association with atherosclerosis has not been considered. The association between habitual SF consumption and asymptomatic carotid atherosclerosis, defined as the presence of plaques and/or increased intima-media thickness, was therefore investigated. One thousand thirty-five randomly selected adult participants without known diabetes and atherosclerotic cardiovascular diseases were cross-sectionally investigated in Palermo, …
Anamnesi di un’architettura del Novecento, manifestazioni patologiche e tecniche per il risanamento: il caso dello Stand Florio a Palermo
2010
Il poster mostra l'anamnesi di un architettura del XX secolo, ed evidenzia le manifestazioni patologiche e le tecniche per il suo restauro conservativo. The poster shows the case history of a twentieth century architecture, and underlines the pathological manifestations and techniques for its restoration.
La fortezza perduta: due ipotesi ricostruttive sul Castellammare di Palermo
2014
L’uso di modelli digitali per lo studio e la prefigurazione dell’architettura è divenuta negli ultimi venti anni una prassi che può ritenersi consolidata; i modelli digitali hanno aperto nuove prospettive di ricerca anche all’indagine storica, specie se condotta su manufatti diruti. In alcuni casi il modello digitale costituisce una soluzione efficace per la prefigurazione di progetti mai realizzati o per l’anastilosi virtuale di edifici perduti; la validità scientifica di tali modelli è strettamente legata alla coerenza delle metodologie di ricostruzione adottate, ad un sistematico ricorso alle fonti documentarie e alla validazione di precedenti ipotesi ricostruttive. Il presente contribut…