Search results for " tolerance"

Latent heat flux variability and response to drought stress of black poplar: A multi-platform multi-sensor remote and proximal sensing approach to re…

2022

Abstract High-throughput mapping of latent heat flux (λET) is critical to efforts to optimize water resources management and to accelerate forest tree breeding for improved drought tolerance. Ideally, investigation of the energy response at the tree level may promote tailored irrigation strategies and, thus, maximize crop biomass productivity. However, data availability is limited and planning experimental campaigns in the field can be highly operationally complex. To this end, a multi-platform multi-sensor observational approach is herein developed to dissect the λET signature of a black poplar (Populus nigra) breeding population (“POP6”) at the canopy level. POP6 comprised more than 4600 …

ANALISI E SVILUPPO DI UN SETUP SPERIMENTALE PER LA DETERMINAZIONE DELLA TENACITÀ A FRATTURA A MODO II NEI MATERIALI COMPOSITI E IBRIDI

Il presente lavoro di Tesi si propone a compimento del percorso previsto dal Ciclo XXVI del corso di Dottorato di Ricerca in Ingegneria Civile e Ambientale – Indirizzo Materiali – seguito durante il triennio Gennaio 2013- Dicembre 2015 presso l’Università degli Studi di Palermo. L’elaborato si sviluppa in due principali sezioni. Dopo un’introduzione all’argomento affrontato, nella prima parte del lavoro, viene analizzato, sia sperimentalmente che numericamente, un setup tipicamente utilizzato nell’industria aeronautica per la caratterizzazione delle delaminazione a MODO II nei materiali compositi (Transverse Crack Tensile test – TCT-test). A partire dai risultati ottenuti dalle analisi prel…

Recombinant growth hormone therapy in patients with ischemic cardiomyopathy : effects on hemodynamics, left ventricular function, and cardiopulmonary…

1999

Background —We studied the effects of recombinant growth hormone (rhGH) on exercise capacity and cardiac function in patients with ischemic cardiomyopathy. Methods and Results —Seven patients (aged 55±9 years) with mild to moderate congestive heart failure (ejection fraction 31±4%) who were on standard therapy were included. The patients were studied at baseline, after 3 months of rhGH treatment, and 3 months after rhGH discontinuation. Cardiac function was assessed by exercise capacity, right heart catheterization at rest and after submaximal exercise, MRI, echocardiography, and Holter monitoring. When administered at a dose of 2 IU/d, rhGH doubled the serum concentration of insulin-like …

Regulatory T-Cells in Antitumor Therapy: Isolation and Functional Testing of CD4<SUP>+</SUP>CD25<SUP>+</SUP> Regulatory T-Cel…

2004

Naturally occurring CD4+CD25+ T regulatory cells originate from the thymus and play a central role regarding the maintenance of peripheral tolerance by suppression of autoreactive T-cell populations. However, T regulatory cells can have beneficial as well as harmful effects. On the one hand, they prevent a variety of autoimmune and inflammatory diseases; but on the other hand, they concomitantly inhibit antitumor immune reactions by suppressing tumor-specific T-cell responses. Therefore, these ambivalent properties of T regulatory cells require detailed investigation especially with respect to a potential therapeutic exploitation of these cells. A prerequisite for such analyses is the isola…

Interleukin-10-treated dendritic cells do not inhibit Th2 immune responses in ovalbumin/alum-sensitized mice.

2005

<i>Background:</i> It is well known that the immunoregulatory cytokine interleukin (IL)-10 inhibits the accessory function of human dendritic cells (DC) in vitro. Recently, we have shown that these IL-10 DC inhibit the production of T helper cell 1 (Th1) and T helper cell 2 (Th2) cytokines by T cells from atopic individuals in vitro. The current study was set out to analyze whether IL-10 DC also exert inhibitory effects in vivo in a murine model of allergy to ovalbumin adsorbed to the adjuvant aluminium hydroxide (OVA/alum). <i>Methods:</i> OVA-pulsed or unpulsed bone marrow-derived DC, treated with IL-10 or left untreated during generation, were injected intravenous…

A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway

2014

CD4(+)CD25(+) regulatory T cells (Tregs) represent a specialized subpopulation of T cells, which are essential for maintaining peripheral tolerance and preventing autoimmunity. The immunomodulatory effects of Tregs depend on their activation status. Here we show that, in contrast to conventional anti-CD4 monoclonal antibodies (mAbs), the humanized CD4-specific monoclonal antibody tregalizumab (BT-061) is able to selectively activate the suppressive properties of Tregs in vitro. BT-061 activates Tregs by binding to CD4 and activation of signaling downstream pathways. The specific functionality of BT-061 may be explained by the recognition of a unique, conformational epitope on domain 2 of th…

Interplay of oxidants and antioxidants during exercise: Implications for muscle health

2010

Muscle contraction results in generation of reactive oxygen and nitrogen species (RONS) at a rate determined by the intensity, frequency, and duration of the exercise protocols. Strenuous exercise causes oxidation of protein, lipid, and DNA, release of cytosolic enzymes, and other signs of cell damage; however, only exhaustive exercise is detrimental. Indeed, the regulation of vascular tone, the excitation-contraction coupling, growth, and differentiation in skeletal muscle, are governed in part by RONS. This is accomplished by RONS interaction with redox-sensitive transcription factors, leading to increased gene expression of antioxidant enzymes, cytoprotective proteins, and other enzymes …

Remission of experimental autoimmune hepatitis is associated with antigen-specific and non-specific immunosuppression.

1993

SUMMARY Experimental autoimmune hepatitis (EAH) is an animal model for autoimmune hepatitis. The disease is T cell-mediated and runs a subacute course, with maximal disease activity around week four after disease induction and a slow ensuing recovery. The aim of the present study was to investigate the immunoregulatory mechanisms that may account for recovery in EAH. It was found that T cell reactivity to liver antigens preceded histological disease, but at the peak of disease activity this T cell response was already suppressed. Active and antigen-specific suppression could be demonstrated, as irradiated splenocytes from animals at the beginning of recovery from EAH were able to suppress i…

Nanoparticles and the immune system: challenges and opportunities

2016

How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group?

2015

This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H. (project 132619) and M.K. (projects 268214 and 272927), a grant from NERC, UK to M.G.R. (grant NE/J020818/1), and NERC, UK PhD studentship to D.J.P. (NE/I528634/1). For many organisms the ability to cold acclimate with the onset of seasonal cold has major implications for their fitness. In insects, where this ability is widespread, the physiological changes associated with increased cold tolerance have been well studied. Despite this, little work has been done to trace chang…