Search results for " tolerance"
showing 10 items of 760 documents
Deep traps in InGaN/GaN single quantum well structures grown with and without InGaN underlayers
2020
The electrical properties and deep trap spectra were compared for near-UV GaN/InGaN quantum well (QW) structures grown on free-standing GaN substrates. The structures differed by the presence or absence of a thin (110 nm) InGaN layer inserted between the high temperature GaN buffer and the QW region. Capacitance-voltage profiling with monochromatic illumination showed that in the InGaN underlayer (UL), the density of deep traps with optical threshold near 1.5 eV was much higher than in the QW and higher than for structures without InGaN. Irradiation with 5 MeV electrons strongly increased the concentration of these 1.5 eV traps in the QWs, with the increase more pronounced for samples witho…
Acute selective ablation of rat insulin promoter-expressing (RIP HER ) neurons defines their orexigenic nature
2012
Rat insulin promoter (RIP)-expressing neurons in the hypothalamus control body weight and energy homeostasis. However, genetic approaches to study the role of these neurons have been limited by the fact that RIP expression is predominantly found in pancreatic β-cells, which impedes selective targeting of neurons. To define the function of hypothalamic RIP-expressing neurons, we set out to acutely and selectively eliminate them via diphtheria toxin-mediated ablation. Therefore, the diphtheria toxin receptor transgene was specifically expressed upon RIP-specific Cre recombination using a RIP-Cre line first described by Herrera (RIP HER -Cre) [Herrera PL (2000) Development 127:2317–2322]. Usi…
Reliability Analysis of Three Homogeneous Fault-tolerant Inverter Topologies
2016
Abstract—In this article, non-redundant fault-tolerant inverter topologies are addressed. A novel fault-tolerant control strategy which enhances performances during post-fault operation is proposed. Benefits from the proposed strategy over conventional fault-tolerant topologies are investigated in terms of system reliability. Cost, post-fault performances, and system reliability of the proposed solution are compared with both a conventional triac-based fault-tolerant inverter and a T-type inverter. The reliability analysis of each selected configuration is carried out by means of Markov chains. The analysis is validated through a comparison of reliability and sensitivity curves. As shown by…
Differential Contribution of the Parental Genomes to a
2019
In European regions of cold climate, S. uvarum can replace S. cerevisiae in wine fermentations performed at low temperatures. S. uvarum is a cryotolerant yeast that produces more glycerol, less acetic acid and exhibits a better aroma profile. However, this species exhibits a poor ethanol tolerance compared with S. cerevisiae. In the present study, we obtained by rare mating (non-GMO strategy), and a subsequent sporulation, an interspecific S. cerevisiae × S. uvarum spore-derivative hybrid that improves or maintains a combination of parental traits of interest for the wine industry, such as good fermentation performance, increased ethanol tolerance, and high glycerol and aroma productions. G…
Comparison of the effects of high-intensity interval running, high-intensity interval circuit training and steady-state running on body composition a…
2015
Introduction. The measurement of body composition is important for several reasons, but nowadays when obesity and overweight are common problems all over the world even more attention should be given to body composition. Excess amount of fat is itself a risk for health, but it also predisposes to many diseases, one of which is diabetes. It has been shown that with regular physical activity and exercise the body composition and body’s glucose regulation can be improved. In common activity guidelines the amount of traditional endurance and resistance training takes hours per week to perform to fill the recommendations. However, since it has been shown that one of the most common reasons for n…
Scientific opinion on an application by Dow AgroSciences LLC (EFSA-GMO-NL-2012-106) for the placing on the market of genetically modified herbicide-t…
2017
Abstract Soybean DAS‐44406‐6 expresses 5‐enolpyruvyl‐shikimate‐3‐phosphate synthase (2mEPSPS), conferring tolerance to glyphosate‐based herbicides, aryloxyalkanoate dioxygenase (AAD‐12), conferring tolerance to 2,4‐dichlorophenoxyacetic acid (2,4‐D) and other related phenoxy herbicides, and phosphinothricin acetyl transferase (PAT), conferring tolerance to glufosinate ammonium‐based herbicides. The molecular characterisation data and bioinformatics analyses did not identify issues requiring assessment for food/feed safety. The agronomic and phenotypic characteristics revealed no relevant differences between soybean DAS‐44406‐6 and its conventional counterpart, except for pod count, seed cou…
Immune tolerance disruption by human parvovirus B19 viral infection mechanisms
2013
Virusinfektioita pidetään kasvavissa määrin suurimpana ympäristöperäisenä syynä, joka vaikuttaa autoimmuunisairauksien kehitykseen ja autoimmuniteetin muodostukseen. Esimerkiksi parvovirus B19 (B19V) on yhdistetty punahukkaan sekä nivelreumaan. On todettu, että B19V:n ei-rakenteellinen proteiini 1 (NS1) aiheuttaa apoptoosia soluissa, jotka eivät tavallisesti ole B19V infektion kohteena. Lisäksi hiljattain on osoitettu, että apoptoosin seurauksena muodostuvat apoptoottiset kappaleet kykenevät esittelemään antigeenejä niitä esittelemään erikoistuneille soluille, kuten makrofageille tai dendriittisoluille. Tämän tutkimuksen tarkoituksena on löytää B19V infektioon liittyviä autoantigeenejä sekä…
Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity
2014
Objective: Environmental conditions (eg, latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including multiple sclerosis (MS). Here, we investigated the mechanisms underlying the beneficial effects of immune regulatory processes induced in the skin by moderate ultraviolet B (UVB) radiation on central nervous system (CNS) autoimmunity. Methods: Effects of UVB light were analyzed in a murine model of CNS autoimmunity (experimental autoimmune encephalomyelitis). Additionally, patients with relapsing–remitting MS were treated with narrowband UVB phototherapy. Immunomodulatory effects were examined in skin biopsies, serum samples, and immune cells of …
Briofītu inducētās izturības pētījumi ar hlorofila a fluorescences analīzes metodi
2015
Darbā aprakstīti briofītu pielāgošanās mehānismi sarežģītiem dzīves apstākļiem. Mērķis bija noskaidrot, vai nepārtrauktā hlorofila a fluorescence ir izmantojama, lai noteiktu briofītu inducēto izturību. Pētījums sastāv no divām daļām. Lai noteiktu briofītu izžūšanas izturību un iespēju izmantot hlorofila a fluorescences metodi tās novērtēšanai, ievāktas trīs sugas, kurām veikta fluorescences analīze paraugu izžūšanas laikā. Lai noteiktu briofītu fluorescences rādītājus briofītiem dažādās temperatūrās, ievāktas 4 sugas. Darbā secināts, ka nepārtraukto hlorofila a fluorescenci ir iespējams izmantot, lai noteiktu briofītu inducēto izturību. Iegūtie fluorescences dati norāda uz izmaiņām briofīt…
Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus.
2021
Abstract BACKGROUND Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high intrinsic aerobic capacity in order to test the association between low physical fitness, a genetic predisposition for obesity, and brain health. We hypothesized that low-capacity runner (LCR) rats with concurrently greater levels of adiposity would have increased hippocampal inflammation and reduced plasticity compared to the more physically fit high-capacity runner (HCR) rats. METHODS We examined markers for inflammation and brain plasticity in the hippocampi of LCR…