Search results for " tolerance"
showing 10 items of 760 documents
Effects of operational assessment of the 4:4 and 4:4/6:6 watch systems on sleepiness, fatigue, and stress responses during patrolling on a navy missi…
2022
The operation of naval vessels involves watchkeeping 24 h per day, which is globally carried out by a variety of different watch systems. In this study, the rotating 4:4 and fixed 4:4/6:6 two-section watch systems were compared in terms of sleepiness, fatigue, and stress responses. The data collection took place on a Finnish Defence Forces' (FDF) Navy missile patrol boat with 15 crew members serving as study participants. The data collection periods lasted two separate weeks (7 days, 6 nights) with the different watch systems. The subjective sleepiness of the participants was assessed before and after every watch using the Karolinska Sleepiness Scale (KSS). Stress responses were assessed da…
Hartinga strupastes Microtus hartingi (RODENTIA, ARVICOLINAE) inbrīdinga tolerance eksperimentālajos apstākļos
2022
Inbrīdings tiek uzskatīts par spēku, kas virza sugas uz izmiršanu (Charlesworth, 2009), tomēr dažos gadījumos tā var izraisīt sugu gēnezi un teorētiski var būt dzīvnieku socialitātes evolūcijas virzītājspēks (Tabadkani et al, 2012). Eksperimentu sērija, kuras mērķis ir modelēt eksperimentālu poligīniju, ir parādījusi atšķirīgu attieksmi pret komunālo dzīvi divās Hārtinga strupastes Microtus hartingi pasugās. Polīgina pasuga Microtus hartingi hartingi bija vairāk pakļauta kommunālai vairošanai. Monogāmajai pasugai Microtus hartingi lydius parādījās augsts sociālā stresa un agresijas līmenis, izraisot reprodukcijas nomākšanu vai zemus reproduktīvus panākumus. Nereti agresija beidzas ar konkur…
Negative impact of freeze–thaw cycles on the survival of tardigrades
2023
Global warming effects in temperate and polar regions include higher average temperatures and a decrease in snow cover, which together lead to an increase in the number of freeze–thaw cycles (FTC). These changes could affect the fitness of both terrestrial and aquatic species. In this study, we tested how tardigrades, ubiquitous microscopic invertebrates, face FTC. Tardigrades are amongst the most resistant animals to unfavorable conditions, including long and deep freezing periods, and are an emerging model group for invertebrate ecology and evolution. We used 12 populations of tardigrades, representing different families within order Parachela, inhabiting different ecosystems (glaciers, s…
Effect of low dissolved oxygen on the viability of juvenile Margaritifera margaritifera : Hypoxia tolerance ex situ
2022
The decline of endangered freshwater pearl mussel (FPM, Margaritifera margaritifera) has been attributed to juvenile mortality caused by low concentrations of dissolved oxygen in the stream substrate resulting from fine sediments (siltation) that impede water exchange in the interstitial microhabitat of juveniles. If low oxygen concentration causes recruitment failure of FPMs, knowledge on the oxygen tolerance of juvenile FPMs is essential for the conservation of the species, as it will justify conservation efforts improving water exchange in the bottom gravel. However, the tolerance of low oxygen of FPM juveniles has not been directly studied. Juvenile FPMs (9–11 months old) were exposed i…
Făgăraș as Jerusalem? Interethnic and interreligious ethos in Transylvania
2017
The study presents Transylvania as a space of ethnic-religious tolerance, having as a case studythe image of the town Făgăraș, as depicted in Eginald Schlattner’s novels. This space appearsas one of a heavenly nuance, based on a long tradition of coexistence of the members ofdifferent ethnic groups and religions. However, the inter-war and post-war period means theemergence of new challenges posed by the confrontation with the harmful effects of the twoideologies: Nazism and Communism. In this way, the dramas of the socio-historical contextinterweave with elements forming young Eginald. They will remain a constant in the writer’slife, offering Făgăraș the role of a forming educational array…
Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1
2018
Immunomodulatory drugs and monoclonal antibody-based immunotherapies have significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent years. These new classes of reagents target malignant plasma cells (PCs) and further modulate the immune microenvironment, which prolongs anti-MM responses and may prevent tumor occurrence. Since MM remains an incurable cancer for most patients, there continues to be a need to identify new tumor target molecules and investigate alternative cellular approaches using gene therapeutic strategies and novel treatment mechanisms. Osteoclasts (OCs), as critical multi-nucleated large cells responsible for bone destruction in >80% …
Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity
2017
Dendritic cells (DCs) are central players in the initiation and control of responses, regulating the balance between tolerance and immunity. Tolerogenic DCs are essential in the maintenance of central and peripheral tolerance by induction of clonal T cell deletion and T cell anergy, inhibition of memory and effector T cell responses, and generation and activation of regulatory T cells. Therefore, tolerogenic DCs are promising candidates for specific cellular therapy of allergic and autoimmune diseases and for treatment of transplant rejection. Studies performed in rodents have demonstrated the efficacy and feasibility of tolerogenic DCs for tolerance induction in various inflammatory diseas…
eIF2α confers cellular tolerance to S. aureus α-toxin
2015
We report on the role of conserved stress-response pathways for cellular tolerance to a pore forming toxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized normal mouse embryonal fibroblasts (MEFs) to the small pore forming S. aureus α-toxin. Sensitization depended on expression of mADAM10, the murine ortholog of a proposed high-affinity receptor for α-toxin in human cells. Similarly, eIF2α (S51A/S51A) MEFs, which harbor an Ala knock-in mutation at the regulated Ser51 phosphorylation site of eukaryotic translation initiation factor 2α, were hyper-sensitive to α-toxin. Inhibition of translation w…
Neuro-endocrine networks controlling immune system in health and disease
2014
The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as multiple sclerosis (MS), might involve factors, hormones, and neural mediators that link the immune and nervous system. These molecules are members of the same superfamily, which allow the mutual and bi-directional neural–immune interaction. More recently, the discovery of leptin, one of the most abundant adipocyte-derived hormones that control food intake and metabolism, has suggested that nutritional/metabolic status, acting …
Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man.
2015
Dendritic cells are (DC) highly specialized professional antigen-presenting cells (APC) that regulate immune responses, maintaining the balance between tolerance and immunity. Mechanisms via which they can promote central and peripheral tolerance include clonal deletion, inhibition of memory T cell responses, T cell anergy and induction of regulatory T cells. These properties have led to the analysis of human tolerogenic DC as a therapeutic strategy for induction or re-establishment of tolerance. In the recent years, numerous protocols for the generation of human tolerogenic DC have been developed and their tolerogenic mechanisms, including induction of regulatory T cells, are relatively we…