Search results for " transient"

Predictive dead time controller for GaN-based boost converters

2017

A dynamic dead time controller is presented, specifically intended to operate in synchronous boost converters based on GaN field-effect transistor switches. These transistors have a reduced stored charge with respect to silicon metal–oxide–semiconductor field-effect transistors with similar breakdown voltage and series resistance, and can operate at higher frequencies with reduced switching losses. On the other hand, the voltage drop in reverse conduction is typically more than doubled with respect to silicon devices resulting in relevant power losses during the free-wheeling phases. Therefore, dynamic control of dead time can be profitably applied even in converters operating in the tens o…

On the use of a meshless solver for PDEs governing electromagnetic transients

2009

In this paper some key elements of the Smoothed Particle Hydrodynamics methodology suitably reformulated for analyzing electromagnetic transients are investigated. The attention is focused on the interpolating smoothing kernel function which strongly influences the computational results. Some issues are provided by adopting the polynomial reproducing conditions. Validation tests involving Gaussian and cubic B-spline smoothing kernel functions in one and two dimensions are reported.

Northern Hemisphere atmospheric pattern enhancing Eastern Mediterranean Transient-type events during the past 1000 years

2021

High-resolution climate model simulations for the last millennium were used to elucidate the main winter Northern Hemisphere atmospheric pattern during enhanced Eastern Mediterranean Transient (EMT-type) events, a situation in which an additional overturning cell is detected in the Mediterranean at the Aegean Sea. The differential upward heat flux between the Aegean Basin and the Gulf of Lion was taken as a proxy of EMT-type events and correlated with winter mean geopotential height at 500 mbar in the Northern Hemisphere (20–90∘ N and 100∘ W–80∘ E). Correlations revealed a pattern similar to the East Atlantic/Western Russian (EA/WR) mode as the main driver of EMT-type events, with the past …

Mediterranean circulation perturbations over the last five centuries: Relevance to past Eastern Mediterranean Transient-type events

2016

The Eastern Mediterranean Transient (EMT) occurred in the Aegean Sea from 1988 to 1995 and is the most significant intermediate-to-deep Mediterranean overturning perturbation reported by instrumental records. The EMT was likely caused by accumulation of high salinity waters in the Levantine and enhanced heat loss in the Aegean Sea, coupled with surface water freshening in the Sicily Channel. It is still unknown whether similar transients occurred in the past and, if so, what their forcing processes were. In this study, sediments from the Sicily Channel document surface water freshening (SCFR) at 1910 ± 12, 1812 ± 18, 1725 ± 25 and 1580 ± 30 CE. A regional ocean hindcast links SCFR to enhanc…

The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes.

2021

Despite the pandemic, 34,154 migrants, refugees or asylum-seekers landed in Sicily (Italy) in 2020, representing the main point of entry by sea into Europe. The SARS-CoV-2 surveillance program among migrants arriving to Sicily via the Mediterranean Sea, made by the combination of clinical examination and molecular testing, has been integrated by full-genome sequencing strains using the NGS technology from the last week of February. To date, more than one hundred full-genome strains have been sequenced and 8 different lineages have been identified mostly belonging to the lineages B.1.1.7 and B.1.525. As global access to COVID-19 vaccines should be ensured, the need to provide more detailed i…

TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling.

2014

Cardiac overexpression of locally acting muscle-restricted (m)IGF-1 and the consequent downstream activation of NAD+-dependent protein deacetylase sirtuin 1 (SIRT1) trigger potent cardiac antioxidative and antihypertrophic effects. Transient receptor potential (TRP) cation channel A1 (TRPA1) belongs to the TRP ion channel family of molecular detectors of thermal and chemical stimuli that activate sensory neurons to produce pain. Recently, it has been shown that TRPA1 activity influences blood pressure, but the significance of TRPA1 in the cardiovascular system remains elusive. In the present work, using genomic screening in mouse hearts, we found that TRPA1 is a target of mIGF-1/SIRT1 sign…

A full wave three dimensional meshless approach for electromagnetic transients

2010

Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA.

1994

The molecular events of brain adaptation to injury that may underlie functional recovery after stroke remain largely undefined. Recent observations of altered gene expression in ischemic brain using animal stroke models have opened new avenues for exploration of the biochemical cascades after stroke [1–11]. These postischemic events include an increase in extracellular excitatory amino acid neurotransmitters such as glutamate. Glutamate receptor–mediated activation of phospholipases and protein kinases results in the alteration of nuclear regulatory processes, including the expression of immediate early genes such as c-fos, junB, and c-jun [5, 12]. The Fos, Jun, and JunB proteins have been …

Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination

2022

Disruption or loss of oligodendrocytes (OLs) and myelin has devastating effects on CNS function and integrity, which occur in diverse neurological disorders, including Multiple Sclerosis (MS), Alzheimer’s disease and neuropsychiatric disorders. Hence, there is a need to develop new therapies that promote oligodendrocyte regeneration and myelin repair. A promising approach is drug repurposing, but most agents have potentially contrasting biological actions depending on the cellular context and their dose-dependent effects on intracellular pathways. Here, we have used a combined systems biology and neurobiological approach to identify compounds that exert positive and negative effects on olig…

Implementation of active infrared NDT techniques using long square heating pulses

2012

The present work describes the implementation of active IR Thermography techniques for the NDT of thick polymer and glass-fibre reinforced polymer (GRP) composite panels. A low cost Thermal NDT set-up is proposed, comprising a single-detector IR camera with low thermal resolution and low frame rate, and common low-power halogen lamps as external heat source devices. The use of halogen lamps in particular requires several seconds of switch-on time in order to deliver meaningful and effective heat quantities. The influence of such long heat deposition intervals is investigated on the possibility to implement Transient Thermography and Lock-In Thermography techniques. Regarding the Transient T…