Search results for " trees."
showing 10 items of 207 documents
In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopha…
2018
The ability to predict new chemical entity performance using in vivo animal models has been under investigation for more than two decades. Pharmaceutical companies use their own strategies to make decisions on the most appropriate formulation starting early in development. In this paper the biopharmaceutical decision trees available in four EFPIA partners (Bayer, Boehringer Ingelheim, Bristol Meyers Squibb and Janssen) were discussed by 7 companies of which 4 had no decision tree currently defined. The strengths, weaknesses and opportunities for improvement are discussed for each decision tree. Both pharmacokineticists and preformulation scientists at the drug discovery & development interf…
EphrinB2 controls vessel pruning through STAT1-JNK3 signalling
2014
Angiogenesis produces primitive vascular networks that need pruning to yield hierarchically organized and functional vessels. Despite the critical importance of vessel pruning to vessel patterning and function, the mechanisms regulating this process are not clear. Here we show that EphrinB2, a well-known player in angiogenesis, is an essential regulator of endothelial cell death and vessel pruning. This regulation depends upon phosphotyrosine-EphrinB2 signalling repressing c-jun N-terminal kinase 3 activity via STAT1. JNK3 activation causes endothelial cell death. In the absence of JNK3, hyaloid vessel physiological pruning is impaired, associated with abnormal persistence of hyaloid vessel…
Wellfounded Trees and Dependent Polynomial Functors
2004
We set out to study the consequences of the assumption of types of wellfounded trees in dependent type theories. We do so by in- vestigating the categorical notion of wellfounded tree introduced in [16]. Our main result shows that wellfounded trees allow us to define initial algebras for a wide class of endofunctors on locally cartesian closed cat- egories.
Space-Frequency Quantization using Directionlets
2007
In our previous work we proposed a construction of critically sampled perfect reconstruction transforms with directional vanishing moments (DVMs) imposed in the corresponding basis functions along different directions, called directionlets. Here, we combine the directionlets with the space-frequency quantization (SFQ) image compression method, originally based on the standard two-dimensional (2-D) wavelet transform (WT). We show that our new compression method outperforms the standard SFQ as well as the state-of-the-art compression methods, like SPIHT and JPEG-2000, in terms of the quality of compressed images, especially in a low-rate compression regime. We also show that the order of comp…
Cholesky decomposition techniques in electronic structure theory
2011
We review recently developed methods to efficiently utilize the Cholesky decomposition technique in electronic structure calculations. The review starts with a brief introduction to the basics of the Cholesky decomposition technique. Subsequently, examples of applications of the technique to ab inito procedures are presented. The technique is demonstrated to be a special type of a resolution-of-identity or density-fitting scheme. This is followed by explicit examples of the Cholesky techniques used in orbital localization, computation of the exchange contribution to the Fock matrix, in MP2, gradient calculations, and so-called method specific Cholesky decomposition. Subsequently, examples o…
Learning Improved Feature Rankings through Decremental Input Pruning for Support Vector Based Drug Activity Prediction
2010
The use of certain machine learning and pattern recognition tools for automated pharmacological drug design has been recently introduced. Different families of learning algorithms and Support Vector Machines in particular have been applied to the task of associating observed chemical properties and pharmacological activities to certain kinds of representations of the candidate compounds. The purpose of this work, is to select an appropriate feature ordering from a large set of molecular descriptors usually used in the domain of Drug Activity Characterization. To this end, a new input pruning method is introduced and assessed with respect to commonly used feature ranking algorithms.
Efficient Multi-scale Patch-Based Segmentation
2015
The objective of this paper is to devise an efficient and accurate patch-based method for image segmentation. The method presented in this paper builds on the work of Wu et al. [14] with the introduction of a compact multi-scale feature representation and heuristics to speed up the process. A smaller patch representation along with hierarchical pruning allowed the inclusion of more prior knowledge, resulting in a more accurate segmentation. We also propose an intuitive way of optimizing the search strategy to find similar voxel, making the method computationally efficient. An additional approach at improving the speed was explored with the integration of our method with Optimised PatchMatch…
Interventi di conservazione degli alberi monumentali in Sicilia
2009
Gli alberi monumentali, elementi fra i più appariscenti del mondo vegetale, possono essere considerati beni unici ed irripetibili. Essi rappresentano un peculiare aspetto della biodiversità che deve essere tutelato e valorizzato alla stessa stregua dei monumenti in pietra, dei centri storici, delle grandi strutture architettoniche (Schicchi & Raimondo, 1999). Negli ultimi anni in Sicilia, come in altre regioni italiane, le iniziative volte alla conoscenza di questo particolare patrimonio culturale si sono intensificate, grazie alla sensibilità di diversi enti territoriali (comuni, province, regioni, parchi naturali). Per questa stessa regione, Schicchi & Raimondo (2005, 2006, 2007) e Schicc…
State and parameter update in a coupled energy/hydrologic balance model using ensemble Kalman filtering
2012
Summary The capability to accurately monitor and describe daily evapotranspiration (ET) in a cost effective manner is generally attributed to hydrological models. However, continuous solution of energy and water balance provides precise estimations only when a detailed knowledge of sub-surface characteristics is available. On the other hand, residual surface energy balance models, based on remote observation of land surface temperature, are characterised by sufficient accuracy, but their applicability is limited by the lack of high frequency and high resolution thermal data. A compromise between these two methodologies is represented by the use of data assimilation scheme to include sparse …
The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
2019
BackgroundCongenital Toxoplasmosis (CT) can have severe consequences. France, Austria, and Slovenia have prenatal screening programs whereas some other countries are considering universal screening to reduce congenital transmission and severity of infection in children. The efficiency of such programs is debated increasingly as seroprevalence among pregnant women and incidence of congenital toxoplasmosis show a steady decrease. In addition, uncertainty remains regarding the effectiveness of pre- and postnatal treatments.MethodTo identify cost-effective strategies, prenatal and neonatal screenings were compared using a decision-analytic model based on French guidelines and current knowledge …