Search results for " trial"

Safety and Tolerance Evaluation of Milk Fat Globule Membrane-Enriched Infant Formulas: A Randomized Controlled Multicenter Non-Inferiority Trial in H…

2014

ObjectiveThis multicenter non-inferiority study evaluated the safety of infant formulas enriched with bovine milk fat globule membrane (MFGM) fractions.MethodsHealthy, full-term infants ( n = 119) age ≤14 days were randomized to standard infant formula (control), standard formula enriched with a lipid-rich MFGM fraction (MFGM-L), or standard formula enriched with a protein-rich MFGM fraction (MFGM-P). Primary outcome was mean weight gain per day from enrollment to age 4 months (non-inferiority margin: –3.0 g/day). Secondary (length, head circumference, tolerability, morbidity, adverse events) and exploratory (phospholipids, metabolic markers, immune markers) outcomes were also evaluated.Res…

A methodological look at the controversy about the influence of salt intake on cardiovascular risk

2012

Cardiovascular diseases are a major cause of premature death and disability. They represent an extraordinarily strong financial burden upon health-care systems in ‘‘developed’’ countries. Elevated blood pressure is a major cause of cardiovascular disease. There is much evidence that cardiovascular risk increases from normal blood pressure (i.e., from 115/75 mmHg upwards) [1]. Overwhelming evidence shows that reducing salt intake from 9–12 g/day to 5–6 g/day lowers blood pressure [2]. Blood pressure is a surrogate endpoint, but may be related to a reduction of morbidity and mortality due to cardiovascular causes. Thus, intensive support and encouragement to cut down on the intake of salt in …

Legacy Effects of Contrasting Long-Term Integrated Weed Management Systems

2022

To reduce reliance on herbicides and maintain crop productivity, integrated weed management (IWM) seeks to optimize synergies between diverse sets of weed management practices combined at the cropping system scale. Nevertheless, data on weed community response to the long-term implementation of IWM practices remain scare. Here, we assessed the effects of four IWM systems with contrasting objectives and practices (S2: transition from superficial tillage to conservation agriculture; S3: no-mechanical weeding; S4: mixed mechanical and chemical weeding; S5: herbicide-free; all with 6 year rotations) compared to a conventional reference (S1: herbicide-based with systematic plowing and a 3 year r…

Real-world experience with dupilumab in severe asthma: One-year data from an italian named patient program

2021

Raffaele Campisi,1 Claudia Crimi,1 Santi Nolasco,2 Bianca Beghè,3 Leonardo Antonicelli,4 Gabriella Guarnieri,5 Nicola Scichilone,6 Morena Porto,2 Luigi Macchia,7 Giulia Scioscia,8 Maria Pia Foschino Barbaro,8 Alberto Papi,9 Nunzio Crimi1,2 1Respiratory Medicine Unit, A.O.U. Policlinico “G. Rodolico -San Marco”, Catania, Italy; 2Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy; 3Respiratory Medicine Unit, Department of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 4Allergy Unit, Department of Internal Medicine, Ancona University Hospital, Ancona, Italy; 5Department of Car…

Virtual Reality, Augmented Reality, and In Vivo Exposure Therapy: A Preliminary Comparison of Treatment Efficacy in Small Animal Phobia

2018

This study aggregated data from three randomized control trials to explore the differential efficacy of three forms of exposure therapy, namely, in vivo (iVET), virtual reality (VRET), and augmented reality (ARET), in the treatment of small animal phobia. Additionally, baseline patient characteristics were used to detect subgroups of patients who showed a differential response to certain treatment modalities. Primary measures were distance covered, anxiety during the behavioral avoidance test (BAT), and overall fear of small animals. A repeated-measures analysis of variance was used to explore the overall treatment effect across the exposure modalities. A cluster analysis and an analysis of…

Percutaneous Recanalization of Chronic Total Occlusions : 2019 Consensus Document from the EuroCTO Club

2019

Since its inception in December 2006, the EuroCTO Club has strived to provide the framework for state-of-the-art chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in Europe and nearby regions. Among its initiatives, the EuroCTO Club has published a set of recommendations regarding the technical aspects of CTO PCI, whose last edition dates to 2012. The EuroCTO Club consensus document discusses CTO PCI clinical indications, techniques and equipment use, as well as the qualifications of operators/centres. Given the considerable amount of progress made by this subspecialty in recent years, there is a need for an updated document that includes data from recent clinical trial…

Orthopedic manual therapy on low back pain with working adults : clinical tests, subclassification and clinical trial of low back pain

2011

La nuisibilité directe des adventices en grandes cultures : quelles réponses nous apportent les essais désherbages ?

2016

The direct harmful effect of weeds in field crops : what do herbicide trials tell us ? Weeds are plants whose undesirable qualities (“harmfulness") outweigh their desirable qualities (trophic resources). Few studies conclude that weeds do not affect crop yield. However, it is difficult to generalize since weeds compete with crops for resources and these resources are spatially and temporally variable. This study analyzed 110 herbicide trials (untreated vs. treated plots) performed in France from 1993 to 2015 on three major grain crops: winter wheat, winter oilseed rape and sunflower. Significant yield losses were found in 92% of wheat trials (average over all trials: -2.6 t/ha), 51% of wint…

Adaptations in body composition, metabolic health and physical fitness during strength or endurance training or their combination in healthy middle-a…

2011

Glosa do wyroku Sądu Najwyższego z dnia 9 lutego 2021 r., III KK 175/20

2022

W niniejszym opracowaniu autor akceptuje stanowisko Sądu Najwyższego, iż jeżeli w toku kontroli kasacyjnej Sąd Najwyższy stwierdzi, że apelacja strony, która wniosła kasację, nie została uwzględniona, a uzasadnienie wyroku sądu odwoławczego rażąco narusza przepis art. 457 § 3 k.p.k., zaś w kasacji w oparciu o „jakość” tego uzasadnienia wywodzony jest zarzut rażącego naruszenia art. 433 § 2 k.p.k. wprost (w treści zarzutu) lub też w uzasadnieniu kasacji (art. 526 § 1 k.p.k. w związku z art. 118 § 1 k.p.k.), to uchybienie takie wymaga uchylenia wyroku sądu odwoławczego, albowiem wymaga tego konstytucyjny art. 45 ust. 1 w zw. z art. 176 § 1 Konstytucji RP i konwencyjny (art. 6 EKPCz) standard …