Search results for " tumor"
showing 10 items of 3819 documents
Increased Connexin 43 Expression as a Potential Mediator of the Neuroprotective Activity of the Corticotropin-Releasing Hormone
2009
CRH is a major central stress mediator, but also a potent neuroprotective effector. The mechanisms by which CRH mediates its neuroprotective actions are largely unknown. Here, we describe that the gap junction molecule connexin43 (Cx43) mediates neuroprotective effects of CRH toward experimentally induced oxidative stress. An enhanced gap junction communication has been reported to contribute to neuroprotection after neurotoxic insults. We show that CRH treatment up-regulates Cx43 expression and gap junctional communication in a CRH receptor-dependent manner in IMR32 neuroblastoma cells, primary astrocytes, and organotypic hippocampal slice cultures. MAPKs and protein kinase A-cAMP response…
Endoscope-assisted Craniotomy
1995
We describe a surgical technique to improve visualization of deep brain structures during craniotomy. The technique, developed in a cadaveric model, combines the use of an operating microscope and a solid-rod lens endoscope. Addition of the endoscope during craniotomy allows the operator to visualize structures that otherwise might not have been seen. An approach to the brain stem is demonstrated.
Classification of Intracranial Tumors
1981
L. Bruns (1914) stated in Krause’s “General Neurosurgery” that brain tumors included all neoplasms growing within the cranial cavity and that these might be divided into three groups: (1) genuine tumors, (2) granulomatous lesions, and (3) parasites. Current use of the term “brain tumor” is more precise and limited to the first of L. Bruns’ categories. Even so, brain tumors represent a large and inhomoge-neous group. The comparison and evaluation of such a diverse set of observations is only possible after making a systematic classification of pertinent data.
Effect of Computed Tomography on Diagnosis of Neurological Disease
1981
Computed tomography is generally considered to be the most reliable and, indeed, the definitive diagnostic technique for demonstration of brain tumors. Approximately 98% of intracra-nial lesions are detected with CT. However, extremely high sensitivity is not the only advantage of CT in diagnosis of intracranial tumors. Accuracy in determining histological type, visualization of anatomical relations to important brain structures, knowledge of the growth pattern, and evidence of space-occupying effects of the tumor are at least as important for the neurosurgeon. In effect, CT studies allow definition of the entire complex “intracranial space-occupying process” by means of a single procedure …
Case Report: Unusual Clinical Presentation of a Rare Cardiac Inflammatory Myofibroblastic Tumor in Children: The Differential Diagnosis With Pediatri…
2021
Introduction: There are still no guidelines about pediatric cardiac cancers. The purpose of this work is to provide new scientific data facilitating the differential diagnosis of a rare cardiac tumor with an unusual presentation, such as the cardiac inflammatory myofibroblastic tumor (IMT).Case Presentation: A 3-year-old male child presented with several symptoms including unconsciousness, vomiting, and drowsiness. A clinical and neurological examination revealed a unilateral (right) motor delay and positive unilateral Babinski sign. Electrocardiogram (ECG) was normal.Diagnostic Assessment: The total body computed tomography (CT) scans showed hypodensity in the left temporal–parietal lobe, …
Correlation between rCBF, Angiography, EEG and Scanning in Brain Tumors
1969
The findings with techniques of different sensitivity, and which investigate different aspects of brain structure and/or function are difficult to correlate. However, such a comparison should help in elucidating the physiopathological mechanisms of brain lesions and the postoperative clinical evolution and prognosis in cases of brain tumors.
EP1299 Laparoscopic – laterally extended pelvic resection
2019
Introduction/Background Lateral isolated gynecological cancer infiltrating the pelvic side wall (PSW) has been considered as a not operable surgery with poor oncological outcome. The development of the laterally extended endopelvic resection (LEER) and surgical progress for disease overcoming the endopelvic fascia infiltrating muscles and nerves, have achieved the possibility to treat those patients with a curative intent. We describe for the first time the feasibility of laparoscopic laterally extended pelvic resection (L-LEPR), with complete removal of disease. Methodology LEPR was defined as an en bloc lateral resection of a pelvic tumor involving sidewall muscle, and/or bone, and/or maj…
Das Pulmonalarteriensarkom - Prä- und postoperative radiologische Befunde bei der Tumorerstmanifestation und beim Rezidiv
2008
Purpose Primary pulmonary artery sarcomas are very rare tumors. Their diagnosis is difficult due to their unspecific symptoms. Still, an early preoperative diagnosis is the only possibility for a potential therapy. Patients and methods 4 pre- and 5 postoperative CT- and three pre- and one postoperative MRT-examination(s) have been evaluated with respect to surgical and histological findings. Results The presence of a convex intraluminal bulging mass spreading mostly from the pulmonary trunc continuously into the peripheral pulmonary artery branches the filling and dilatation of the vessels, the tumor's inhomogeneity indicating hemorrhages and necrosis and the appearance of intrapulmonary no…
Discordancia clínico-radiológica y resolución espontánea de un hematoma postcateterización epidural
2008
Neuraxial techniques are considered safe if certain guidelines are followed, but they are not risk free. We report the case of an 81-year-old woman with an invasive bladder tumor who underwent radical cystectomy with a Bricker-type procedure. General anesthesia was used and epidural analgesia was also provided for surgical and postoperative pain management. Late in the postoperative recovery period a large epidural hematoma was diagnosed based on radiologic signs of spinal cord compression, in the absence of symptoms other than mild and progressive back pain that developed after extubation. The surgeon decided against emergency surgery to reduce compression. Symptoms resolved gradually, and…
Role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) for prognosis in endometrial cancer
2007
Abstract Background. Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) contribute to the invasiveness of many carcinomas. Here, we studied a possible association between cytosolic uPA and PA-1 concentrations in tumor tissue with prognosis in patients with endometrial cancer. Methods. Cytosolic concentrations of uPA and PAI-1 were determined in 69 primary endothelial adenocarcinomas using an enzyme-linked immunoassay (ELISA). A possible influence of uPA and PAI-1 was studied by multivariate Cox regression adjusting for the established clinical prognostic factors FIGO-stage, grading, depth of invasion, diabetes mellitus and age. Results. Both uPA ( …