Search results for " value"

Evaluation of DR and CR digital mammography systems based on phantom and breast dosimetry.

2006

Digital mammography has been progressively introduced in screening centers, since recent evolution of CR and DR detectors. However, it is questionable which exposure conditions would be more suitable when these techniques are applied, in order to reduce the glandular breast doses, as they are related with induced carcinogenesis. Several exposures have been performed in CR and DR mammography units for comparing absorbed doses during quality control assessments and during screening, diagnosis and treatment. In the first case, the CIRS11A mammographic phantom has been used with standard exposure conditions (28 kV, AEC mode with blackening +0, 50:50 glandularity and 4.5 compressed breast thickn…

The role of the reporting framework MIATA within current efforts to advance immune monitoring

2014

The course of fatigue in patients with gynecologic and breast cancer

2013

Objective: The objective of this study is to examine the course of fatigue in female cancer patients during the first months after treatment. Methods: We examined a sample of 110 patients suffering from gynecological or breast cancer. Fatigue was assessed with two questionnaires, the Multidimensional Fatigue Inventory (MFI) and the fatigue scale of the quality of life questionnaire European Organisation for Research and Treatment of Cancer (EORTC QLQ-C30). Participants were tested during their stay in the hospital (t1), two weeks after discharge (t2), and three months after discharge (t3). Results: Fatigue in the patients’ sample was markedly higher than the general population reference val…

What is the order of the two-dimensional polymer escape transition?

2007

An end-grafted flexible polymer chain in three-dimensional space between two pistons undergoes an abrupt transition from a confined coil to a flowerlike conformation when the number of monomers in the chain, $N$, reaches a critical value. In two-dimensional (2D) geometry, excluded-volume interactions between monomers of a chain confined inside a strip of finite length $2L$ transform the coil conformation into a linear string of blobs. However, the blob picture raises questions about the nature of this escape transition. To check theoretical predictions based on the blob picture we study 2D single-polymer chains with excluded-volume interactions and with one end grafted in the middle of a st…

Use of molecular topology for the prediction of physico-chemical, pharmacokinetic and toxicological properties of a group of antihistaminic drugs

2002

We used molecular connectivity to search mathematical models for predicting physico-chemical (e.g. the partition coefficient, P), pharmacokinetic (e.g. the time of maximum plasma level, and toxicological properties (lethal dose, LD) for a group of antihistaminic drugs. The results obtained clearly reveal the high efficiency of molecular topology for the prediction of these properties. Randomization and cross-validation by use of leave-one-out tests were also performed in order to assess the stability and the prediction ability of the connectivity functions selected.

Modelling bioconcentration of pesticides in fish using biopartitioning micellar chromatography.

2005

Ecotoxicity assessment is essential before placing new chemical substances on the market. An investigation of the use of the chromatographic retention (log k) in biopartitioning micellar chromatography (BMC) as an in vitro approach to evaluate the bioconcentration factor (BCF) of pesticides in fish is proposed. A heterogeneous set of 85 pesticides from six chemical families was used. For pesticides exhibiting bioconcentration in fish (experimental log BCF > 2), a quantitative retention-activity relationships (QRAR) model is able to perform precise log BCF estimations of new pesticides. Considering the present data, the results based on log k seem to be more reliable than those from availabl…

Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs

2006

Existing Trichomonas vaginalis therapies are out of reach for most trichomoniasis people in developing countries and, where available, they are limited by their toxicity (mainly in pregnant women) and their cost. New antitrichomonal agents are needed to combat emerging metronidazole-resistant trichomoniasis and reduce the side effects associated with currently available drugs. Toward this end, atom-based bilinear indices, a new TOMOCOMD-CARDD molecular descriptor, and linear discriminant analysis (LDA) were used to discover novel, potent, and non-toxic lead trichomonacidal chemicals. Two discriminant functions were obtained with the use of non-stochastic and stochastic atom-type bilinear in…

A topological substructural approach for the prediction of P-glycoprotein substrates

2006

A topological substructural molecular design approach (TOPS-MODE) has been used to predict whether a given compound is a P-glycoprotein (P-gp) substrate or not. A linear discriminant model was developed to classify a data set of 163 compounds as substrates or nonsubstrates (91 substrates and 72 nonsubstrates). The final model fit the data with sensitivity of 82.42% and specificity of 79.17%, for a final accuracy of 80.98%. The model was validated through the use of an external validation set (40 compounds, 22 substrates and 18 nonsubstrates) with a 77.50% of prediction accuracy; fivefold full cross-validation (removing 40 compounds in each cycle, 80.50% of good prediction) and the predictio…

Bond-based bilinear indices for computational discovery of novel trypanosomicidal drug-like compounds through virtual screening

2014

Two-dimensional bond-based bilinear indices and linear discriminant analysis are used in this report to perform a quantitative structure-activity relationship study to identify new trypanosomicidal compounds. A data set of 440 organic chemicals, 143 with antitrypanosomal activity and 297 having other clinical uses, is used to develop the theoretical models. Two discriminant models, computed using bond-based bilinear indices, are developed and both show accuracies higher than 86% for training and test sets. The stochastic model correctly indentifies nine out of eleven compounds of a set of organic chemicals obtained from our synthetic collaborators. The in vitro antitrypanosomal activity of …

News Selection Within Customer Magazines

2017

Customer magazines blur the boundaries between journalistic reporting and organizational information. On the one hand, customer magazines are intended to communicate the interests, brands, products, and services of an organization. On the other hand, their topics, style, and layout resemble those of journalistic publications, from which readers expect independent and objective reporting. While customer magazines are distributed in high numbers throughout different industries and play an increasingly important role in the media landscape, they have hardly been the focus of researchers to date. It is therefore quite unclear how editorial decisions are made within these publications. This stud…