Search results for " value"
showing 10 items of 3662 documents
Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and …
1996
A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls. This finding suggests that genetic predisposition to schizophrenia may be affected by a functional 5-HT2A receptor variant that is in linkage disequilibrium with 102T/C. In the present study, we have sought to identify genetic variation in the 5-HT2A receptor gene by screening genomic DNA samples from 91 unrelated subjects comprising 45 patients with schizophrenia and 46 healthy controls by using single-strand conformation analysis. We have identified four nucleotide sequence …
A new decision model for economic evaluation of novel therapies for HCV
2014
In 2014, the European Medicines Agency (EMA) has given the license to two new direct-acting antiviral: sofosbuvir and simeprevir. The evidence provided by the studies, reported a high rate of SVR even in patients with decompensated cirrhosis. This and other innovative elements are potentially adept at changing the entire natural course of HCV. However, the dramatic prevalence rates of HCV observed in Italy, and the high prices that are expected to be required by the pharmaceutical industry, raises some critical issues about how to regulate access to such drugs. The objective of this article is to present a new decision model for the evaluation of novel therapies for HCV. This model is inten…
Proof I: Upper Bounds
2019
In this chapter we study upper bounds on singular values and determinants of certain operators related to Pδ. The bounds are not probabilistic; they only depend on a certain smallness of the perturbation.
A beam finite element for magneto-electro-elastic multilayered composite structures
2012
Abstract A new finite element based upon an elastic equivalent single-layer model for shear deformable and straight magneto-electro-elastic generally laminated beam is presented. The element has six degrees of freedom represented by the displacement components and the cross-section rotation of its two nodes. The magneto-electric boundary conditions enter the discrete problem as work-equivalent forces and moments while the electro-magnetic state characterization constitutes a post-processing step. The element possesses the superconvergence property for the static problem of beams with uniform cross-section and homogenous material properties along the beam axis direction. Moreover, it is free…
The value of value: Further excursions on the meaning and role of customer value
2011
Grounded on fundamental marketing principles, the concept of customer value has been revisited and refined by academicians and practitioners for the last 30 years. However, research devoted to achieving a consistent theoretical and conceptual development of valuerelated concepts has proceeded apace without ever reaching full closure. The present essay seeks reasons behind remaining deficiencies in value-related research and offers a review intended to move our understanding of customer value toward what promises to become a more enlightened future. The topic of value is approached by theoretical analysis and conceptual development. First, ‘‘the challenge’’ of value research is presented: th…
Predictive value of the Merrill-Palmer-R Scale applied during the first year of live
2016
Resumen basado en el de la publicación Títulos, resumen y palabras clave en inglés y español El valor predictivo de una escala de desarrollo utilizado durante el primer año de vida es de gran interés en la planificación de las intervenciones tempranas. El valor predictivo de un instrumento es la probabilidad de acertar el diagnóstico de trastorno o retraso en el desarrollo de un niño. Se analizaron las puntuaciones de escala Merrill-Palmer-R (MP-R) en una muestra de 291 niños menores de un año de la Comunidad Valenciana. A pesar de que no se distribuyen normalmente las puntuaciones de la escala MP-R en esta muestra, los resultados predichos eran buenos. Además, las puntuaciones de desarroll…
Changes in achievement values from primary to lower secondary school among students with and without externalizing problems
2017
This study examined the effect of students' externalizing problems on changes in values that they attach to math across the transition from primary to lower secondary school. Data pertaining to externalizing problems and to intrinsic, attainment, and utility values in math were gathered using the self-ratings of students in Grades 6 and 7. The analysis involved a comparison between students who reported persistent high externalizing problems before and after the transition (n = 63; 59% boys) and those who had low or non-existent externalizing problems before and after the transition (n = 1352; 50% boys). The results of a mixed-design analysis of covariance (ANCOVA) showed uniformly that stu…
Parenting styles and short- and long-term socialization outcomes: a study among Spanish adolescents and older adults
2018
En este estudio se analizaron los estilos parentales de socialización familiar y sus resultados a corto y largo plazo aplicando el modelo de dos dimensiones y cuatro tipologías de socialización. Los resultados de la socialización parental analizados en los hijos fueron la autoestima y la internalización de los valores sociales. Los participantes fueron adolescentes (n = 571) y adultos mayores (n = 527) españoles. Los resultados indicaron que tanto los adolescentes como los adultos mayores de las familias indulgentes mostraron igual e incluso mayor autoestima que los de las familias autorizativas, mientras que los de las familias autoritarias y negligentes se asociaban de manera consistente …
Legislación educativa española y educación en valores
2013
El presente artículo pretende ofrecer un análisis acerca de las referencias a la educación en valores presentes en la legislación educativa española desde que la reforma de la década de los noventa, la conocida LOGSE entró en vigor. Ofrece un breve repaso de las reformas legales posteriores a la LOGSE, en cuanto a sus indicaciones sobre el proceso educativo como un proceso educativo global, centrado más en educar y formar ciudadanos críticos que ciudadanos en posesión de simples contenidos conceptuales. Las referencias legales forman parte, casi en su mayoría, de lo que podríamos denominar legislación centrada en la diversidad. La conclusión que se intenta mostrar es cómo el proceso educati…
Predicting bullying: maladjustment, social skills and popularity
2012
In order to prevent bullying, research has characterised the adolescents involved in terms of their social skills, maladjustment and popularity. However, there is a lack of knowledge concerning the relationships between these variables and how these relationships predict bullying involvement. Moreover, the literature has focused on pure bullies and victims, despite the fact that bully-victims are known to be the most troubled. The aim of this work is to study the relationships between these variables and their predictive value, focusing on the bully-victim role. The sample (N = 641) is made up of adolescents aged between 12 and 17 years. The results mainly indicate that the level of maladju…