Search results for " vessels"
showing 10 items of 303 documents
Simplified dynamic pressure method for kLa measurement in aerated bioreactors
2010
Abstract A simplified version of the dynamic pressure method for measuring mass-transfer coefficients in gas–liquid systems is proposed. With this method oxygen concentration in the liquid phase is monitored after a sudden change of total pressure is applied to the system. With respect to the original technique introduced by Linek [14] the simplified version here proposed greatly simplifies the data treatment, yet resulting in good accuracy for most practical purposes. In practice, with the help of a simple mathematical model, it is found that the dynamic oxygen concentration response, when plotted as residual driving force versus time in a semi-log diagram, should be expected to finally se…
Gas-liquid-solid Operation of a High Aspect Ratio Self-ingesting Reactor
2012
Gas-liquid stirred vessels are widely employed to carry out chemical reactions involving a gas reagent and a liquid phase. The usual way for introducing the gas stream into the liquid phase is through suitable distributors placed below the impeller. An interesting alternative is that of using “self ingesting” vessels where the headspace gas phase is injected and dispersed into the vessel through suitable surface vortices. In this work the performance of a Long Draft Tube Self-ingesting Reactor (LDTSR) dealing with three-phase (gas-liquid-solid) systems, is investigated. Preliminary experimental results on the effectiveness of this contactor for particle suspension and gas-liquid mass transf…
Computational flow dynamics in a geometric model of intussusceptive angiogenesis.
2009
Intussusceptive angiogenesis is a process that forms new blood vessels by the intraluminal division of a single blood vessel into two lumens. Referred to as nonsprouting or intussusceptive angiogenesis, this angiogenic process has been described in morphogenesis and chronic inflammation. Mechanical forces are relevant to the structural changes associated with intussusceptive angiogenesis because of the growing evidence that physiologic forces influence gene transcription. To provide a detailed analysis of the spatial distribution of physiologic shear stresses, we developed a 3D finite element model of the intraluminal intussusceptive pillar. Based on geometries observed in adult intussuscep…
The control of the residual lifetimes of carbon fibre-reinforced composite pressure vessels
2015
International audience; The understanding of the degradation of carbon fibre composites, with emphasis on the use of these composites in filament-wound pressure vessels, is explored. Earlier studies by many researchers have led to a general appreciation of the mechanisms involved; however, only recently have both computational power and experimental techniques become sufficiently developed to allow for the use of quantitative analyses. It is shown that damage is controlled by fibre failure, and that initially this occurs randomly within the structure. In monotonic loading, the development of clusters of fibre breaks causes rapid failure; however, under maintained loads the kinetics of damag…
The effects of linearly increasing flip angles on 3D inflow MR angiography
1994
As recently demonstrated, spin saturation effects in 3D time-of-flight (TOF) MR angiography (MRA) can be reduced by using RF pulses with linearly increasing flip angles (ramp pulses) in the main direction of flow. We developed a model for calculating the signal distribution of proton flow within the excitation volume (slab) for different ramp slopes and compared the results with the measured distribution for the lower-leg arteries. The ramp pulses were generated using the Fourier transformation of the desired excitation profiles. With a bandwidth of 6 kHz and a pulse length of 2.56 ms satisfactory ramps with variable slopes were generated and applied in a standard flow-compensated 3D FISP s…
Effect of the loading rate on ultimate strength of composites. Application: Pressure vessel slow burst test
2013
International audience; The strength of unidirectional elastic fibre composites is shown to depend on the loading rate as the viscoelastic nature of the matrix results in a fall in breaking load as the rate is reduced. The simulation of the accumulation of fibre breaks leading to failure, takes into account all physical phenomena involved fibre failure, including the stochastic nature of fibre strength, stress transfer through the matrix between reinforcements, interfacial debonding and the viscoelastic nature of the matrix. The kinetics of composite failure are seen to involve the initial formation of random fibre breaks which at higher loads coalesce into clusters of broken fibres. The ra…
Health monitoring of high performance composite pressure vessels,
2018
International audience; The most important form of damage in carbon fiber reinforced composite pressure vessels is the failure of the fibers however the rate of fiber failure is controlled by the viscoelastic nature of the matrix, which determines overall in-service lifetimes. This type of damage is very different from that encountered with metal pressure vessels and requires a detailed understanding in order to ensure reliability. Innovative proof testing methods based on these processes are necessary. The damage processes and the means of quantifying them are discussed. Their reliability under pressure over periods of decades is analyzed. Intrinsic safety factors linked directly to the pr…
Free vortex shape in Uncovered Unbaffled Stirred Tanks (UUST) agitated by Rushton turbines
2012
The main feature of unbaffled stirred tanks is the highly swirling liquid motion, which leads to the formation of a central vortex on the liquid free surface, when the vessel is operated without top-cover (Uncovered Unbaffled Stirred Tanks, UUST). In this work, original data on fluid dynamics characteristics of (UUST) agitated by a Rushton turbine are presented. In particular, digital image analysis is employed to accurately assess vortex shape and validate an original model for its description. The model describes vortex shape in the case of sub-critical systems (when vortex bottom is placed above the impeller plane) as well as in the case of super-critical systems (when vortex bottom fall…
Nipple-sparing mastectomy and breast reconstruction with a deep inferior epigastric perforator flap using thoracodorsal recipient vessels and a low l…
2018
Background Nipple-sparing mastectomy poses challenges in providing esthetically-pleasing immediate autologous breast reconstruction. This study was to investigate the outcomes of nipple-sparing mastectomy with breast reconstruction using free abdominal flaps between two different recipient sites. Methods Between 2010 and 2016, 79 patients who underwent nipple-sparing mastectomy with autologous breast reconstruction using thoracodorsal (TD) vessels in 30 cases or internal mammary (IM) vessels in 49 cases were investigated. Demographics, intraoperative findings, complications, and quality of life using Breast-Q questionnaire were compared between two groups. Results All flap survived. There w…
Involvement of PKC and NF-κB in Nitric Oxide Induced Apoptosis in Human Coronary Artery Smooth Muscle Cells
2001
Apoptosis of vascular smooth muscle cells is critically involved in progression of atherosclerosis and may prevent intimal hyperplasia in restenosis and vascular remodeling. Nitric oxide (NO) is known to induce apoptosis, but the signaling pathways still remain unclear. We investigated p53 accumulation, protein kinase C (PKC) activation and nuclear transcription factor (NF-kappaB) binding activity as possible signaling mechanisms of NO-induced apoptosis. Apoptosis was induced dose-dependently with the NO-donors sodiumnitroprusside (SNP: 232+/-48%) and SIN-1 (241+/-90% of actinomycin D induced apoptosis; means +/- SEM, *por =0.05 vs. control) in HSMC. Inhibition of PKC significantly attenuat…