Search results for "γ"

Structure of rotational bands in 253No

2009

In-beam gamma-ray and conversion electron spectroscopic studies have been performed on the 253 No nucleus. A strongly coupled rotational band has been identified and the improved statistics allows an assignment of the band structure as built on the $\ensuremath 9/2^-[734]_{\nu}$ ground state. The results agree with previously known transition energies but disagree with the tentative structural assignments made in earlier work.

High-spin states in the neutron-rich A∼100 region

2009

Two experimental setups have been used to study excited states of neutron‐rich nuclei in the A∼100 region. Extended level schemes and lifetime measurements were obtained using deep‐inelastic and fusion‐fission reactions with the CLARA‐PRISMA spectrometer and the Ge‐array GASP respectively. Experimental information from GASP has been used to complement the CLARA‐PRISMA experiment. Time spectra have been used to measure the lifetimes of isomeric states. Preliminary results are presented for 89Rb.

γ‐Agregation operators and some aspects of generalized aggregation problem

2010

We explore questions related to the aggregation operators and aggregation of fuzzy sets. No preliminary knowledge of the aggregation operators theory and of the fuzzy sets theory are required, because all necessary information is given in Section 2. Later we introduce a new class of γ‐aggregation operators, which “ignore” arguments less than γ. Due to this property γ‐aggregation operators simplify the aggregation process and extend the area of possible applications. The second part of the paper is devoted to the generalized aggregation problem. We use the definition of generalized aggregation operator, introduced by A. Takaci in [7], and study the pointwise extension of a γ‐agop. First publ…

Glutathione content, glutathione S-transferase and γ-glutamyltranspeptidase activities in mid-gut gland of Procambarus clarkii: time course in the pr…

1988

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours

2019

BACKGROUND: Interferon-induced expression of programmed cell death ligands (PD-L1/PD-L2) may sustain tumour immuneevasion. Patients featuring MET amplification, a genetic lesion driving transformation, may benefit from anti-MET treatment. We explored if MET-targeted therapy interferes with Interferon-gamma modulation of PD-L1/PD-L2 in MET-amplified tumours.METHODS: PD-L1/PD-L2 expression and signalling pathways downstream of MET or Interferon-gamma were analysed in MET-amplified tumour cell lines and in patient-derived tumour organoids, in basal condition, upon Interferon-gamma stimulation, and after anti-MET therapy.RESULTS: PD-L1 and PD-L2 were upregulated in MET-amplified tumour cells up…

P3‐344: γ‐secretase‐dependent APP processing occurs either at the plasma membrane or in the endocytic compartments independent of the APP wild‐type o…

2008

Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.

2012

We present an integrated approach to identify and optimize a novel class of γ-secretase modulators (GSMs) with a unique pharmacological profile. Our strategy included (i) virtual screening through application of a recently developed protocol (PhAST), (ii) synthetic chemistry to discover structure–activity relationships, and (iii) detailed in vitro pharmacological characterization. GSMs are promising agents for treatment or prevention of Alzheimer’s disease. They modulate the γ-secretase product spectrum (i.e., amyloid-β (Aβ) peptides of different length) and induce a shift from toxic Aβ42 to shorter Aβ species such as Aβ38 with no or minimal effect on the overall rate of γ-secretase cleavag…

Prostatas specifiskā membrānas antigēna liganda 68Ga-PSMA-HBED-CC ražošana un tā kvalitātes kontrole

2017

Darbā veikta prostatas specifiskā membrānas antigēna (PSMA) liganda 68Ga-PSMA-HBED CC ražošana, izmantojot divas dažādas tehnoloģijas un salīdzināta abu produktu kvalitāte un ražošanas efektivitāte. Darbā izmantotas dažādas analīžu metodes – radioaktivitātes mērījumi, γ – spektrometrija un hromatogrāfiskās metodes.

Absorption band at 7.6 eV induced by γ-irradiation in silica glasses

2001

Optical absorption of defects induced by γ-irradiation in both natural and synthetic silica is experimentally investigated in the vacuum-ultraviolet (UV) range. Our results show that γ-rays, in a dose range of 1000 Mrad, induce an absorption band centered at 7.6 eV, the so-called E band, whose growth kinetics is not related to γ-activated precursors but to defects of the glassy matrix directly induced via the breaking of Si–O bonds occurring under γ-irradiation. Moreover, we observe that γ-rays do not bleach the E band present in some silica samples before irradiation, so ruling out that the associated defects can be precursors of the paramagnetic E′ centers, also induced by γ-irradiation.

IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations

2007

BACKGROUND: Rhinovirus-induced acute asthma is the most frequent trigger for asthma exacerbations. OBJECTIVE: We assessed which inflammatory mediators were released from bronchial epithelial cells (BECs) after infection with rhinovirus and then determined whether they were also present in subjects with acute virus-induced asthma, with the aim to identify a biomarker or biomarkers for acute virus-induced asthma. METHODS: BECs were obtained from bronchial brushings of steroid-naive asthmatic subjects and healthy nonatopic control subjects. Cells were infected with rhinovirus 16. Inflammatory mediators were measured by means of flow cytometry with a cytometric bead array. Subjects with acute a…