Search results for "(2)-2"

Estructura, resultados y límites de la política económica en Rusia

2003

El ascenso de Vladimir Putin a la presidencia de Rusia significa un punto de inflexión en la economía del país. En particular, uno de los cambios más importantes se ha mostrado en la política económica. En este artículo se explican los contenidos de la nueva política económica aplicada en Rusia. Después de una exposición de los objetivos y de las políticas tradicionales, se abordan las políticas de corte institucional que pretenden cambiar el marco de la toma de decisiones en Rusia. Junto a la exposición de políticas económicas, se realiza también una exposición sistemática de los principales resultados obtenidos hasta principios del año 2003 y, para finalizar, se apuntan los límites más im…

WIN 55,212-2, agonist of cannabinoid receptors, prevents amyloid β1-42 effects on astrocytes in primary culture

2015

Alzheimer's disease (AD), a neurodegenerative illness involving synaptic dysfunction with extracellular accumulation of Aβ1-42 toxic peptide, glial activation, inflammatory response and oxidative stress, can lead to neuronal death. Endogenous cannabinoid system is implicated in physiological and physiopathological events in central nervous system (CNS), and changes in this system are related to many human diseases, including AD. However, studies on the effects of cannabinoids on astrocytes functions are scarce. In primary cultured astrocytes we studied cellular viability using MTT assay. Inflammatory and oxidative stress mediators were determined by ELISA and Western-blot techniques both in…

The Synthetic Cannabinoid WIN 55,212-2 Sensitizes Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-I…

2010

In this article, we demonstrate that the synthetic cannabinoid R-(+)-(2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrol[1,2,3-de]-1,4-benzoxazin-6-yl)-(1-naphthalenyl) methanone mesylate (WIN 55,212-2) sensitizes human hepatocellular carcinoma (HCC) cells to apoptosis mediated by tumor necrosis-related apoptosis inducing ligand (TRAIL). The apoptotic mechanism induced by treatment with WIN/TRAIL combination involved the loss of the mitochondrial transmembrane potential and led to the activation of caspases. In HCC cells, WIN treatment induced the up-regulation of TRAIL death receptor DR5, an effect that seemed to be related to the increase in the level of p8 and CHOP, two factors implicat…

"Table 52" of "Studies of QCD at e+ e- centre-of-mass energies between 91-GeV and 209-GeV."

2004

Combined results for ALPHAS.

"Table 3" of "Measurements of e+ e- ---> K+ K- eta, K+ K- pi0 and K0(s) K+- pi-+ cross- sections using initial state radiation events"

2008

The cross section for E+ E- --> PHI PI0 with statistical errors only.

FERNÁNDEZ PARADAS, Antonio Rafael. "Historia de la historia del mueble en España. Teoría, historiografía y corrientes metodológicas (1872-2011)"

2016

Effect of Space charge accumulation inside the thermoplastic insulation of a loaded HVDC model cable

2021

The space charge accumulation phenomenon represents one of the main degradation factors for the dielectrics employed in the field of the HVDC transmission. For this reason, the recommendation IEEE Std 1732-2017 has been proposed. In that standard, due to the importance attributed at the space charge phenomenon, the experts suggest the introduction of the space charge measurement in HVDC cables during the prequalification or type tests, by means of the PEA method. However, despite for tests in flat specimens the PEA technique is well consolidated, for cable specimens difficulties are still present. In particular, the PEA cell output signal is strongly conditioned by the arranged measurement …

"Table 1" of "Studies of QCD at e+ e- centre-of-mass energies between 91-GeV and 209-GeV."

2004

Mean charged particle multiplicities at different c.m. energies.

"Table 10" of "Studies of QCD at e+ e- centre-of-mass energies between 91-GeV and 209-GeV."

2004

Peak position in XI distribution for different c.m. energies.

Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an acute rat model of temporal lobe epilepsy

2016

The exogenous cannabinoid agonist WIN 55,212-2, (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-6-Yl]-1-naphthalenylmethanone (WIN), has revealed to play a role on modulating the hyperexcitability phenomena in the hippocampus. Cannabinoid-mediated mechanisms of neuroprotection have recently been found to imply the modulation of transient receptor potential vanilloid 1 (TRPV1), a cationic channel subfamily that regulate synaptic excitation. In our study, we assessed the influence of pharmacological manipulation of TRPV1 function, alone and on WIN antiepileptic activity, in the Maximal Dentate Activation (MDA) acute model of temporal lobe epilepsy. Our r…