Search results for "-Ag"
showing 10 items of 514 documents
Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome
2021
The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role …
Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol.
2009
The beta-adrenergic agonist 1 (zilpaterol) is used as production enhancer in cattle. Binding experiments of separated enantiomers on recombinant human beta(2)-adrenergic and mu-opioid receptors and functional studies showed that the (-)-1 enantiomer accounts for essentially all the beta(2)-adrenergic agonist activity and that it exhibits less affinity toward the mu-opioid receptor than (+)-1, which is a mu-opioid receptor antagonist. X-ray crystallography revealed the absolute configuration of (-)-1 to be 6R,7R.
Desensitization of inhibitory prejunctional alpha 2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves.
1993
To find out whether sympathetic nerves of the rabbit heart possess pharmacologically relevant prejunctional imidazoline receptors different from α-autoreceptors, the inhibition by oxymetazoline, aganodine and BDF 6143 (4-chloro-2-[2-imidazoline-2-ylamino]-isoindoline hydrochloride) of endogenous noradrenaline overflow evoked by stimulation of extrinsic postganglionic sympathetic nerves (0.66 Hz, 80 pulses) was investigated. In addition we wanted to find out whether either type of these prejunctional receptors undergoes desensitization upon pre-exposure to respective agonists. The α2-adrenoceptor agonist oxymetazoline inhibited the evoked noradrenaline overflow (2.9 nmol/l, IC50; about 90010…
Rank two aCM bundles on the del Pezzo fourfold of degree 6 and its general hyperplane section
2018
International audience; In the present paper we completely classify locally free sheaves of rank 2 with vanishing intermediate cohomology modules on the image of the Segre embedding $\mathbb{P}^2$ x $\mathbb{P}^2 \subseteq \mathbb{P}^8$ and its general hyperplane sections.Such a classification extends similar already known results regarding del Pezzo varieties with Picard numbers 1 and 3 and dimension at least 3.
Proper triangular Ga-actions on A^4 are translations
2013
We describe the structure of geometric quotients for proper locally triangulable additve group actions on locally trivial A^3-bundles over a noetherian normal base scheme X defined over a field of characteristic 0. In the case where dim X=1, we show in particular that every such action is a translation with geometric quotient isomorphic to the total space of a vector bundle of rank 2 over X. As a consequence, every proper triangulable Ga-action on the affine four space A^4 over a field of characteristic 0 is a translation with geometric quotient isomorphic to A^3.
Geometry of the projectivization of ideals and applications to problems of birationality
2018
In this thesis, we interpret geometrically the torsion of the symmetric algebra of the ideal sheaf I_Z of a scheme Z defined by n+1 equations in an n-dimensional variety. This is equivalent to study the geometry of the projectivization of I_Z. The applications of this point of view concern, in particular, the topic of birational maps of the projective space of dimension 3 for which we construct explicit birational maps that have the same algebraic degree as their inverse, free and nearly-free curves for which we generalise a characterization of free curves by extending the notion of Milnor and Tjurina numbers. We tackle also the topic of homaloidal hypersurfaces, our original motivation, fo…
Implementation Challenges for Supporting Coworking Virtual Enterprises
2013
The creation of co working alliances is usually restricted to the coworkers in the same workspace. However, they might not necessarily be best partners to take advantage of a collaboration opportunity. To break the spatial constrains and find the best partners irrespective of their co working spaces location, our proposal is to represent and manage the co working alliances as virtual enterprises (VEs) and to develop a multi-agent system (MAS) that serves as Virtual Breeding Environment (VBE). In this paper we provide the basis for the future development of this system. Thus, we introduce the co working VEs distinguishing features and the initial proposals on how to implement the MAS to addr…
Development and validation of a liquid chromatography tandem mass spectrometry method for the analysis of beta-agonists in animal feed and drinking w…
2010
A reproducible, sensitive and selective multiresidue analytical method for seven beta-agonists: clenbuterol (CBT), clenpenterol (CPT), ractopamine (RTP), brombuterol (BBT), mabuterol (MBT), mapenterol (MPT), and hydroxymethylclenbuterol (HMCBT) was developed and validated by using liquid chromatography tandem mass spectrometry (LC-MS/MS) in feed and drinking water samples. The validation was achieved according to the criteria laid down in the Commission Decision 2002/657/EC, however it was necessary to use minimum required performance limits (MRPLs) proposed by the Community Reference Laboratories (CRLs) due to the lack of maximum residue limits (MRLs) for beta-agonists. By setting up these…
Arborescent Supply Chains: the effect of OUT policies
2013
The objective of this paper is to analyze the impact of the smoothing replenishment rules on a divergent supply chain. To this purpose we simulate a classical four echelon serially- linked supply chain model and an arborescent supply chain model under two scenarios, i.e. classical OUT and smoothing replenishment rule. We show that the divergent supply chain structure always performs worse than the serial supply chain and how smoothing the order pattern may decrease this discrepancy.
The Protohistoric sword from Le Gué-de-Velluire (Vendée, France): a pasticcio's history unveiled by archaeometrical research
2020
International audience; The Gué-de-Velluire sword (Vendée, France) is part of the Rochebrune collection collected during the 19 th and the 20 th centuries and now preserved in the Dobrée Museum in Nantes (Loire-Atlantique, France). The unusual shape of its hilt, its uncorroded rivets and the rather uncommon combination of a bronze grip with an iron blade made this sword an exceptional object. It has been depicted in a large number of papers since the 20 th century, but the question of its authenticity has hardly ever been tackled. New analyses performed with the support of the Dobrée Museum, the Arc'Antique laboratory and Ghent University delivered new data enabling us to discuss this delic…