Search results for "-Dimethyl-5"

showing 10 items of 36 documents

CCDC 1537522: Experimental Crystal Structure Determination

2017

Related Article: Pankaj Chauhan, Suruchi Mahajan, Uğur Kaya, Anssi Peuronen, Kari Rissanen, and Dieter Enders|2017|J.Org.Chem.|82|7050|doi:10.1021/acs.joc.7b01113

4'-[(t-butoxycarbonyl)amino]-33'-dimethyl-5'-oxo-11'-diphenyl[4'5'-dihydro-1H1'H-[44'-bipyrazole]]-5-yl acetateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Mode and mechanism of neurotensin action in rat proximal colon

1997

Abstract This study examined the mechanism of action of neurotensin on intraluminal pressure in rat proximal colon. The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca 2+ -free solution, and was antagonized by nifedipine (1–5–10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylate) (10–100–1000 nM). Neurotensin, in the presence of nifedipine (10 nM) and atropine (1 μM), induced a tetrodotoxin-insensitive inhibitory effect, which was antagonized by SR 48692 (2[(1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxy-phenyl)pyrazol-3-yl) carbonyl amino]tricyclo (3.3.1.1. 3.7 ) decan-2-carboxylic a…

Atropinemedicine.medical_specialtyNifedipineColonchemistry.chemical_elementCholinergic AgonistsIn Vitro TechniquesCalciumInhibitory postsynaptic potentialApaminCholinergic Antagonistschemistry.chemical_compoundNifedipineInternal medicinemedicineAnimalsReceptors NeurotensinRats WistarNeurotensinPharmacologyChemistryMuscle Smooth3-Pyridinecarboxylic acid 14-dihydro-26-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl esterBethanecholCalcium Channel BlockersRatsCalcium Channel AgonistsEndocrinologyApaminMechanism of actionQuinolinesExcitatory postsynaptic potentialBiophysicsPyrazolesCalciummedicine.symptomMuscle Contractionmedicine.drugMuscle contractionNeurotensinEuropean Journal of Pharmacology
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CCDC 206077: Experimental Crystal Structure Determination

2006

Related Article: S.Azzouzi, M.El Messaoudi, M.Esseffar, R.Jalal, F.H.Cano, M.del Carmen Apreda-Rojas, L.R.Domingo|2005|J.Phys.Org.Chem.|18|522|doi:10.1002/poc.892

Diethyl 3-(p-chlorophenyl)-2-(N'-(p-chlorophenyl)-N'-(2'7'-dimethyl-5'-oxo-5'6'-dihydro-2H-(124)triazepin-3'-yl)hydrazino)-23-dihydro(134)thiadiazole-25-dicarboxylateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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L-type calcium channel activity in human atrial myocytes as influenced by 5-HT.

1993

5-Hydroxytryptamine (10 mumol/l; 5-HT) exerted a positive inotropic effect associated with an increase in the Ca2+ current (ICa) in the human right atrium. For detailed analysis, L-type Ca2+ channel currents were recorded from cell-attached patches using 100 mmol/l Ba2+ as charge carrier. Ca2+ channel activity was identified, first, by burst-like inwardly directed currents and, second, by the appearance of long channel openings promoted by Bay K 8644 (1 mumol/l) upon repetitive depolarizations from -80 to 0 mV. The unitary conductance of the Ca2+ channel amounted to 25.8 pS. During superfusion with 5-HT, ensemble averaged (mean) current was enhanced by about 60%. The increase in mean curren…

MaleSerotoninchemistry.chemical_elementAction PotentialsGatingCalciumIn Vitro TechniquesMoleCyclic AMPHumansL-type calcium channelPhosphorylation5-HT receptorAgedPharmacologyMyocardiumIsoproterenolInfantDepolarizationHeartGeneral MedicineAnatomy3-Pyridinecarboxylic acid 14-dihydro-26-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl esterMiddle AgedMyocardial ContractionElectrophysiologyElectrophysiologyKineticschemistryChild PreschoolBiophysicsFemaleCalcium ChannelsIon Channel GatingCommunication channelNaunyn-Schmiedeberg's archives of pharmacology
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Role of K+ and Ca2+ fluxes in the cerebroarterial vasoactive effects of sildenafil

2007

The aim of this study was to assess the role of K(+) and Ca(2+) fluxes in the cerebroarterial vasoactive effects of the phosphodiesterase-5 inhibitor sildenafil. We used isolated rabbit basilar arteries to assess the effects of extracellular K(+) raising on sildenafil-induced vasodilatation, and studied the pharmacological interaction of sildenafil with selective modulators of membrane K(+) and Ca(2+) channels. Expression of Kv1 subunits of K(+) channels was assessed at messenger and protein levels. Parallel experiments were carried out with zaprinast for comparison. Sildenafil (10 nM-0.1 mM) induced concentration-dependent relaxation of endothelin-1 (10 nM)-precontracted arteries, which wa…

Malemedicine.medical_specialtyCalcium Channels L-Typemedicine.drug_mechanism_of_actionPhosphodiesterase InhibitorsVasodilationIn Vitro TechniquesPharmacologyPiperazinesSildenafil Citratechemistry.chemical_compoundInternal medicinemedicineAnimalsChannel blockerRNA MessengerSulfonesPharmacologyTetraethylammoniumDose-Response Relationship DrugChemistryDepolarization3-Pyridinecarboxylic acid 14-dihydro-26-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl esterIberiotoxinEndocrinologyPurinesBasilar ArterycGMP-specific phosphodiesterase type 5PotassiumShaker Superfamily of Potassium ChannelsCalciumRabbitsZaprinastPhosphodiesterase 5 inhibitorEuropean Journal of Pharmacology
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Calcium dependence of the contraction produced by endothelin (ET-1) in isolated guinea-pig trachea.

1990

Endothelin (ET-1, 1 pM to 0.1 microM) produced a concentration-dependent contraction of isolated guinea-pig trachea. BAY K 8644 (1 microM) did not significantly alter the concentration-response curve for ET-1. Incubation with nicardipine (10 microM) partly inhibited responses to low concentrations (10 pM to 1 nM) of ET-1 while verapamil (10 microM) and diltiazem (10 microM) were ineffective. La3+ (10 microM) and Cd2+ (10 microM) preferentially depressed the responses evoked by high concentrations (30 nM-0.1 microM) of ET-1 without affecting the responses evoked by low concentrations of the peptide. Incubation in Ca2(+)-free (with EDTA, 1 mM) medium resulted in suppression of the responses e…

Malemedicine.medical_specialtyContraction (grammar)NicardipineGuinea PigsIndomethacinchemistry.chemical_elementCalciumBiologyIn Vitro TechniquesPotassium ChlorideGuinea pigInternal medicinemedicineExtracellularAnimalsDiltiazemPharmacologyEndothelinsMuscle Smooth3-Pyridinecarboxylic acid 14-dihydro-26-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl esterCalcium Channel BlockersTracheaEndocrinologychemistryVerapamilCalciumEndothelin receptormedicine.drugMuscle ContractionEuropean journal of pharmacology
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CCDC 1474975: Experimental Crystal Structure Determination

2016

Related Article: Uğur Kaya, Pankaj Chauhan, Kristina Deckers, Rakesh Puttreddy, Kari Rissanen, Gerhard Raabe, Dieter Enders|2016|Synthesis|48|3207|doi:10.1055/s-0035-1561468

Space GroupCrystallography13-dimethyl-5-(nitromethyl)-7-phenyl-15-dihydro-2H-pyrano[23-d]pyrimidine-24(3H)-dioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 200198: Experimental Crystal Structure Determination

2004

Related Article: D.Pomeranc, D.Jouvenot, J.-C.Chambron, J.-P.Collin, V.Heitz, J.-P.Sauvage|2003|Chem.-Eur.J.|9|4247|doi:10.1002/chem.200304716

Space GroupCrystallography1616-Dimethyl-5811212427-hexaoxa-4445-diazapentacyclo[29.8.2^1215^.2^1720^.1^136^.1^3135^]pentatetraconta-1(45)12141719313335(44)36384042-dodecaeneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1899761: Experimental Crystal Structure Determination

2019

Related Article: Carlos Vila, Nisshanth Raj Dharmaraj, Antonio Faubel, Gonzalo Blay, M. Luz Cardona, M. Carmen Muñoz, Jose R. Pedro|2019|Eur.J.Org.Chem.|2019|3040|doi:10.1002/ejoc.201900328

Space GroupCrystallography3-[(34-dimethyl-5-oxo-1-phenyl-45-dihydro-1H-pyrazol-4-yl)methylidene]-1-(prop-2-en-1-yl)-13-dihydro-2H-indol-2-oneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2009109: Experimental Crystal Structure Determination

2020

Related Article: Jonathan Bould, Kamil Lang, Kaplan Kirakci, Luis Cerdán, Daniel Roca-Sanjuán, Antonio Francés-Monerris, William Clegg, Paul G. Waddell, Marcel Fuciman, Tomáš Polívka, Michael G. S. Londesborough|2020|Inorg.Chem.|59|17058|doi:10.1021/acs.inorgchem.0c02277

Space GroupCrystallography5'6':67-conjuncto-(33'-dimethyl-6'7':8'9':9'10'-tri-muH-nido-decaborane)-(44'-dimethyl-56:89:910-tri-muH-nido-decaborane)Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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