Search results for "002"
showing 10 items of 183 documents
The clinical impact of donor-specific antibodies in heart transplantation.
2018
Donor-specific antibodies (DSA) are integral to the development of antibody-mediated rejection (AMR). Chronic AMR is associated with high mortality and an increased risk for cardiac allograft vasculopathy (CAV). Anti-donor HLA antibodies are present in 3-11% of patients at the time of heart transplantation (HTx), with de novo DSA (predominantly anti-HLA class II) developing post-transplant in 10-30% of patients. DSA are associated with lower graft and patient survival after HTx, with one study suggesting a three-fold increase in mortality in patients who develop de novo DSA (dnDSA). DSA against anti-HLA class II, notably DQ, are at particularly high risk for graft loss. Although detection o…
OR18-03 Functional TSH Receptor Antibodies Are a Biomarker for Graves’ Disease - a Prospective Trial
2020
Abstract Objective We aimed to evaluate the clinical utility and predictive value of stimulatory (TSAb) and blocking (TBAb) TSH receptor antibodies in the management of Graves’ disease (GD). Methods Hundred well-defined, consecutive, unselected, untreated hyperthyroid patients with GD were enrolled in a prospective two-year trial. Methimazole (MMI) was administered for 24 weeks according to baseline serum concentrations of free T3/free T4. Starting dose was 5–30 mg/day. Through a titration regimen, this dose was respectively tapered or increased at each subsequent study visit as the patient became euthyroid or remained hyperthyroid. Goals of therapy were to maintain normal fT4 and TSH level…
Early-Career Researchers’ Perceptions of the Prevalence of Questionable Research Practices, Potential Causes, and Open Science
2017
Abstract. Young researchers of today will shape the field in the future. In light of current debates about social psychology’s research culture, this exploratory survey assessed early-career researchers’ beliefs (N = 88) about the prevalence of questionable research practices (QRPs), potential causes, and open science as a possible solution. While there was relative consensus that outright fraud is an exception, a majority of participants believed that some QRPs are moderately to highly prevalent what they attributed primarily to academic incentive structures. A majority of participants felt that open science is necessary to improve research practice. They indicated to consider some open s…
Climatic gradients along the windward slopes of Mount Kenya and their implication for crop risks. Part 2 : crop sensitivity.
2016
16 pages; International audience; Mount Kenya is an equatorial mountain whose climatic setting is fairly simple (two rainy seasons in March–May, the Long Rains, and October–December, the Short Rains) though concealing significant spatial variations related to elevation and aspect (part I, Camberlin et al., 2014). This part II is dedicated to the sensitivity of sorghum yields to climate variability in space and time, with a focus on the intra-seasonal characteristics of the rainy seasons. To that aim we use the crop model SARRA-H calibrated for the region and fed with rainfall, temperature, wind speed, humidity and solar radiation data over the period 1973–2001 at three stations located on t…
Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
2021
Abstract Background Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range,…
L'emergenza sismica a Palermo. Finanziamenti e interventi in centro storico
2012
Il contributo affronta il tema della riqualificazione della città storica a Palermo. Grazie ai finanziamenti pubblici concessi ai privati a seguito dell'emergenza sismica del 2002 furono avviati una serie di importanti restauri nel mandamento Tribunali Castellammare.
Clinical use of intracoronary imaging. Part 1: guidance and optimization of coronary interventions. An expert consensus document of the European Asso…
2018
This Consensus Document is the first of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The first document appraises the role of intracoronary imaging to guide percutaneous coronary interventions (PCIs) in clinical practice. Current evidence regarding the impact of intracoronary imaging guidance on cardiovascular outcomes is summarized, and patients or lesions most likely to derive clinical benefit from an imaging-guided intervention are identified. The relevance of the u…
Gadamer : art, poétique et ontologie
2016
International audience; Cet ouvrage collectif s'ouvre sur la traduction d un texte de Gadamer encore inédit en français intitulé De la lecture des édifices et des images. En continuité avec ce texte, c'est autour de la réflexion philosophique de Gadamer sur l'art et l'expérience du beau que gravitent les différentes contributions des spécialistes de l'herméneutique qui participent à ce livre. Le but consiste non seulement à comprendre quel rapport entretiennent l'art, la poétique et l'ontologie dans la philosophie de Gadamer, mais aussi à proposer des éléments d'interprétation renouvelée de Vérité et méthode. Cet ouvrage propose un aperçu des discussions les plus actuelles dans les études g…
Reduction of environmental pollutants for prevention of cardiovascular disease: it’s time to act
2020
Abstract
Verso un diritto penale geneticamente modificato? A proposito di un recente progetto di riforma dei reati agroalimentari
2016
The article analyses, first of all, – also in a comparative key – the most significant problematic aspects emerging from the resort, very frequent in the food sector, to typification techniques based on references to European legislation. Lexical hybridisms and precautionary needs of the European model of food security risk to affect the classical categories of criminal law, not only at the level of relevant concepts, but also at that of fundamental principles. After an overall look to the contents of the reform Project of agro-food crimes elaborated by the Caselli Commission in 2015, the study focuses particularly on the way the Project suggests to rewrite the cornerstone offence establish…