Search results for "002"

Prehistoric Settlement and Population in the Madonie Mountains. New Data from the Archaeological Survey

2010

The aim of the Madonie research project is to analyse mobility strategies and the use of a mountainous territory by relating geomorphologic features, raw material sources and landscape to the prehistoric settlement. For this purpose we planned an intensive and systematic survey of sample areas, selected on geo-morphological, altimetric and archaeological criteria, correlated to a palaeoenvironmental investigation based on the study of palynological sequence samples coming from wet areas of the Madonie territory and from archaeological deposits. Le projet de recherche sur la Madonie analyse les stratégies de mobilité et l’exploitation du territoire de montagne, en reliant les caractéristique…

Application of Mathematical Models in Analysis of Heat Losses in the Buildings

2006

Physical model of heat balance for separate living room is discussed, which allows to analyse the distributions of the flow of air and temperature depending on the physical conditions and geometry. The model enables to choose the optimal surface area of building elements and their properties in order to decrease the heat losses and improve the conditions of thermal comfort. Room with bounding constructions and real dimensions is modelled that helps to understand the peculiarities of heat transfer process in the room as well as distribution of various characteristic quantities and their dependence on the different conditions. Multiple parameters are varied in 2D calculations and their influe…

TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies

2009

AIM: To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors, in combination with the death receptor ligand tumor necrosis factor-related apoptosis inducing ligand (TRAIL), on overcoming TRAIL resistance in hepatocellular carcinoma (HCC) and to study the efficacy of agonistic TRAIL antibodies, as well as the commitment of antiapoptotic BCL-2 proteins, in TRAIL-induced apoptosis. METHODS: Surface expression of TRAIL receptors (TRAIL-R1-4) and expression levels of the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL were analyzed by flow cytometry and Western blotting, respectively. Knock-down of MCL-1 and BCL-xL was performed by transfecting specific small interfering RNA…

INTEGRAL and RXTE observations of accreting millisecond pulsar IGR J00291+5934 in outburst

2005

Simultaneous observations of the accretion-powered millisecond pulsar IGR J00291+5934 by International Gamma-Ray Astrophysics Laboratory and Rossi X-ray Timing Explorer during the 2004 December outburst are analysed. The average spectrum is well described by thermal Comptonization with an electron temperature of 50 keV and Thomson optical depth tau_T ~ 1 in a slab geometry. The spectral shape is almost constant during the outburst. We detect a spin-up of the pulsar with nudot=8.4x10E-13 Hz/s. The ISGRI data reveal the pulsation of X-rays at a period of 1.67 milliseconds up to ~150 keV. The pulsed fraction is shown to increase from 6 per cent at 6 keV to 12--20 per cent at 100 keV. This is n…

Telemedicine and Remote Screening for COVID-19 in Inflammatory Bowel Disease Patients: Results From the SoCOVID-19 Survey

2020

OR18-01 Effect of Teprotumumab on Proptosis Reduction Across Various Demographic Sub-Groups

2020

Abstract Introduction: Teprotumumab, an insulin-like growth factor 1 receptor inhibitory monoclonal antibody, was recently shown to significantly reduce proptosis in patients with active, moderate-to-severe thyroid eye disease (TED) in phase 2 and phase 3 clinical trials.1,2 Prior analyses have demonstrated a combined trial proptosis response (≥2 mm reduction) rate of 77.4% in the teprotumumab group and 14.9% in the placebo group after 24 weeks of therapy (p < 0.001).3 The current analysis was performed to investigate whether or not patient demographic characteristics influence the teprotumumab proptosis response. Methods: Data from two 24-week randomized, double-masked, placebo-cont…

SAT-429 Systemic Safety Analysis of Mycophenolate in Graves’ Orbitopathy

2020

Abstract Context The dual antiproliferative mechanism of mycophenolate appears to be beneficial in Graves’ orbitopathy (GO). Methods The safety data, which is of utmost importance in immunomodulation, from the two major randomized mycophenolate trials [“Chinese trial” (1) and “European Group on Graves’ Orbitopathy (EUGOGO) trial” (2)] and the original database of the EUGOGO trial were systematically analyzed. Treatment efficacy stratified by individual visual parameters of clinical disease activity and severity were also compared. Results A total of 129 adverse events (AE) involving 50 patients (29.4%) were noted among all mycophenolate-treated patients. Mycophenolate sodium plus intravenou…

Theoretical and Experimental Comparison of Total Harmonic Distortion Factors for the Evaluation of Harmonic and Interharmonic Pollution of Grid-Conne…

2006

Grid connected photovoltaic systems are increasingly used in electrical distribution systems. However, they inject distorted currents. Therefore special attention must be paid to harmonic and interharmonic measurements. The new edition of IEC 61000-4-7 introduces the concept of harmonic and interharmonic groups, which implies new expressions for Total Harmonic Distortion factors. In the paper a theoretical and experimental comparison is made between the different total harmonic distortion factors in order to show which of the currently defined distortion factors is best-suited to detect harmonic and interharmonic pollution. Experimental tests were carried out first by means of a calibrator …

Translation as a measure of literary domination: the case of Quebec literature translated in Spain (1975-2004)

2010

Recent literary manifestos claim that “the center is no longer the center” (Le Devoir 2007). Indeed, it is generally admitted that Quebec literature has been more or less independent from the French field since the 1970’s. However, the analysis of the translation of this literature –its international circulation, and the almost compulsory stopover in France before being selected for translation by the agents of other literary fields– reveals various mechanisms through which the French symbolic center still exerts its power. Drawing on the application of Pierre Bourdieu’s sociology of culture to the international space (Casanova 1999; Sapiro 2007, 2008; etc.), this article argues that transl…

Efficacy and cost-effectiveness of guided and unguided internet- and mobile-based indicated transdiagnostic prevention of depression and anxiety (ICa…

2019

Background Depression and anxiety are highly prevalent and often co-occur. Several studies indicate the potential of disorder-specific psychological interventions for the prevention of each of these disorders. To treat comorbidity, transdiagnostic treatment concepts seem to be a promising approach, however, evidence for transdiagnostic concepts of prevention remains inconclusive. Internet- and mobile-based interventions (IMIs) may be an effective means to deliver psychological interventions on a large scale for the prevention of common mental disorders (CMDs) such as depression and anxiety. IMIs have been shown to be effective in treating CMDs, e.g. in reducing symptoms of depression and an…