Search results for "002"
showing 10 items of 183 documents
Discovery of a soft X-ray 8 mHz QPO from the accreting millisecond pulsar IGR J00291+5934
2016
In this paper, we report on the analysis of the peculiar X-ray variability displayed by the accreting millisecond X-ray pulsar IGR J00291+5934 in a 80 ks-long joint NuSTAR and XMM-Newton observation performed during the source outburst in 2015. The light curve of the source was characterized by a flaring-like behavior, with typical rise and decay time scales of ~120 s. The flares are accompanied by a remarkable spectral variability, with the X-ray emission being generally softer at the peak of the flares. A strong quasi periodic oscillation (QPO) is detected at ~8 mHz in the power spectrum of the source and clearly associated with the flaring-like behavior. This feature has the strongest po…
Final Results of a Phase I/II Trial of the Combination Bendamustine and Rituximab With Temsirolimus (BeRT) in Relapsed Mantle Cell Lymphoma and Folli…
2020
Abstract. In this phase I/II study, we explored the combination of Temsirolimus with Bendamustine and Rituximab (BeRT) in patients with relapsed or refractory (r/r) follicular lymphoma (FL) or mantle cell lymphoma (MCL). Patients with 1 to 3 previous therapies received Bendamustine (90 mg/m2, day 1 + 2) and Rituximab (375 mg/m2, day 1) with Temsirolimus in doses from 25 to 75 mg in phase I and 50 mg Temsirolimus in phase II, added on day 1, 8, 15 of a 28 days cycle. The primary endpoint of the phase II was ORR at the end of treatment. Overall, 39 (29 MCL, 10 FL) patients were included. Median age was 71 years and median pretreatment number was 2. Grade 3/4 non-hematologic adverse events wer…
Efectos del desarrollo sostenible percibido por el consumidor. Una propuesta de modelo de hipermercados en Ecuador
2020
Resumen El objetivo de este trabajo fue analizar la incidencia del desarrollo sostenible sobre la cadena de efectos: valor percibido - capital de marca - lealtad. Para ello, se propone un modelo teórico de relaciones que se contrasta a partir de una muestra de 317 clientes de hiper mercados en Ecuador. Los resultados, aplicando una metodología exploratoria y confirmatoria, combinada con regresión por mínimos cuadrados parciales, mostraron que tanto las acciones de desarrollo sostenible como el valor percibido son pilares maestros sobre los que se puede apoyar la estrategia minorista. Ambas se muestran como variables clave por su naturaleza, en cuanto son multidimensio nales, y por su alcanc…
Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver dise…
2015
Scope Flavonoids and related compounds seem to have favorable effects on nonalcoholic fatty liver disease (NAFLD) progression, although the exact mechanisms implicated are poorly understood. In this study, we aimed to investigate the effect of the flanovol quercetin on gene expression deregulation involved in the development of NAFLD, as well as the possible implication of phosphatidylinositol 3-kinase (PI3K)/AKT pathway modulation. Methods and results We used an in vivo model based on methionine- and choline-deficient (MCD) diet-fed mice and an in vitro model consisting of Huh7 cells incubated with MCD medium. MCD-fed mice showed classical pathophysiological characteristics of nonalcoholic…
Exclusive transduction of human CD4+ T Cells upon systemic delivery of CD4-targeted lentiviral vectors
2015
Abstract Playing a central role in both innate and adaptive immunity, CD4+ T cells are a key target for genetic modifications in basic research and immunotherapy. In this article, we describe novel lentiviral vectors (CD4-LV) that have been rendered selective for human or simian CD4+ cells by surface engineering. When applied to PBMCs, CD4-LV transduced CD4+ but not CD4− cells. Notably, also unstimulated T cells were stably genetically modified. Upon systemic or intrasplenic administration into mice reconstituted with human PBMCs or hematopoietic stem cells, reporter gene expression was predominantly detected in lymphoid organs. Evaluation of GFP expression in organ-derived cells and blood …
Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strat…
2021
Abstract Recent advances in human genetics, together with a large body of epidemiologic, preclinical, and clinical trial results, provide strong support for a causal association between triglycerides (TG), TG-rich lipoproteins (TRL), and TRL remnants, and increased risk of myocardial infarction, ischaemic stroke, and aortic valve stenosis. These data also indicate that TRL and their remnants may contribute significantly to residual cardiovascular risk in patients on optimized low-density lipoprotein (LDL)-lowering therapy. This statement critically appraises current understanding of the structure, function, and metabolism of TRL, and their pathophysiological role in atherosclerotic cardiova…
Estructura, resultados y límites de la política económica en Rusia
2003
El ascenso de Vladimir Putin a la presidencia de Rusia significa un punto de inflexión en la economía del país. En particular, uno de los cambios más importantes se ha mostrado en la política económica. En este artículo se explican los contenidos de la nueva política económica aplicada en Rusia. Después de una exposición de los objetivos y de las políticas tradicionales, se abordan las políticas de corte institucional que pretenden cambiar el marco de la toma de decisiones en Rusia. Junto a la exposición de políticas económicas, se realiza también una exposición sistemática de los principales resultados obtenidos hasta principios del año 2003 y, para finalizar, se apuntan los límites más im…
La Crète des frères Reinach
2019
Joseph, Salomon et Théodore, les frères Je-Sais-Tout des chansonniers de Montmartre et les fils d’Hermann Reinach, homme d’affaires et patron de presse influent, ont, chacun, croisé dans leur vie la Crète. L’aîné, Joseph l’a envisagée alors qu’il rêvait dans sa jeunesse d’ambassades et de carrière diplomatique : les affaires crétoises furent pour l’homme politique un aspect de la question d’Orient. Sans jamais visiter l’île, Salomon l’a inlassablement décrite comme celle de toutes les surpris...
The use of Endurant stent-graft for abdominal aortic aneurysm: the story about extension of instruction for use with persistent good results of stent…
2012
The Endurant stent-graft (Medtronic, Inc., Minneapolis, MN, USA) is a latest generation device for the treatment of abdominal aortic aneurysm. The idea behind designing such a graft came from the intention to broad the instruction for use (IFU) and to enable it to treat more challenging anatomy including the 10mm neck lengths, and more severe suprarenal and infrarenal angulations. Endurant stent-graft has active fixation through suprarenal stent with anchoring pins to provide migration resistance, optimized heights of stents and spacing between them for improved flexibility and conformability, low-profile delivery system with hydrophilic coating and controlled simple deployment mechanism. S…
"Table 1" of "Search for promptly produced heavy quarkonium states in hadronic Z decays"
1996
The analysis of hadrons (from X) provides to distinguish of the various decay modes of Z-boson (see text).