Search results for "004"

REGGAE : a novel approach for the identification of key transcriptional regulators

2019

Abstract Motivation Transcriptional regulators play a major role in most biological processes. Alterations in their activities are associated with a variety of diseases and in particular with tumor development and progression. Hence, it is important to assess the effects of deregulated regulators on pathological processes. Results Here, we present REGulator-Gene Association Enrichment (REGGAE), a novel method for the identification of key transcriptional regulators that have a significant effect on the expression of a given set of genes, e.g. genes that are differentially expressed between two sample groups. REGGAE uses a Kolmogorov–Smirnov-like test statistic that implicitly combines assoc…

Decreased Fibrogenesis After Treatment with Pirfenidone in a Newly Developed Mouse Model of Intestinal Fibrosis

2016

BACKGROUND Fibrosis as a common problem in patients with Crohn's disease is a result of an imbalance toward excessive tissue repair. At present, there is no specific treatment option. Pirfenidone is approved for the treatment of idiopathic pulmonary fibrosis with both antifibrotic and anti-inflammatory effects. We subsequently investigated the impact of pirfenidone treatment on development of fibrosis in a new mouse model of intestinal fibrosis. METHODS Small bowel resections from donor mice were transplanted subcutaneously into the neck of recipients. Animals received either pirfenidone (100 mg/kg, three times daily, orally) or vehicle. RESULTS After administration of pirfenidone, a signif…

Raman spectroscopy as a tool for ecology and evolution.

2017

7 pages; International audience; Scientists are always on the lookout for new modalities of information which could reveal new biological features that are useful for deciphering the complexity of biological systems. Here, we introduce Raman spectroscopy as a prime candidate for ecology and evolution. To encourage the integration of this microscopy technique in the field of ecology and evolution, it is crucial to discuss first how Raman spectroscopy fits within the conceptual, technical and pragmatic considerations of ecology and evolution. In this paper, we show that the spectral information holds reliable indicators of intra- and interspecies variations, which can be related to the enviro…

Management von Kundenbeziehungen durch Brand Communities

2010

Das Marketing wurde in den letzten Jahrzehnten durch die Betrachtung von dyadischen Beziehungen zwischen Anbietern und Nachfragern dominiert (Bruhn/Georgi 2006). Dabei verstand man Transaktionen zunachst als diskrete (voneinander unabhangige) Ereignisse, spater auch als relationale Phanomene (Bruhn 2002a; 2002b). Die Marketingtheorie und -praxis vernachlassigte (mit wenigen Ausnahmen) jedoch, Interaktionen zwischen Konsumenten zu analysieren. Gerade Begegnungen zwischen Individuen beeinflussen jedoch deren Wahrnehmung, Beurteilung und Akzeptanz von Produkten und Marken (Bearden/Etzel 1982). Die isolierte Betrachtung des Konsumentenverhaltens als Entscheidung Einzelner ist daher um Einflusse…

How to diagnose and treat abdominal compartment syndrome after endovascular and open repair of ruptured abdominal aortic aneurysms

2014

Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are frequently encountered in patients treated for ruptured abdominal aortic aneurysms (rAAA) and carry a high morbidity and mortality risk. Despite these facts, IAH/ACS are still overlooked by many physicians, timely diagnosis is missed and treatment often inadequate. All staff involved in the treatment of rAAA should be aware of the risk factors predicting IAH/ACS, the profound implications and derangements on all organ systems, the clinical presentation, the appropriate measurement of intra-abdominal pressure to detect IAH/ACS and the current treatment options for these detrimental syndromes. This comprehensive r…

Deliberación celérica desde la periferia

2005

Análisis sobre el consumo de medios y los usos telemáticos que los españoles desplegaron entre el 11-M y el 14-M. Consideramos los días correlativos de la semana previa, la primera de la campaña electoral, para establecer qu medios aumentaron más su audiencia y experimentaron mayor flujo de información. Veremos cómo se alteró la esfera pública para generar un nuevo proceso de "formación de opiniones" celérico

Medios digitales, transmisión de información y formación del espacio público: comunicación de masas y comunicación en red ante el 11M

2004

En los días transcurridos entre el atentado del 11M y las elecciones del 14M se vivió en España un intenso debate en torno a la autoría de los atentados que tuvo una incidencia difícil de determinar en las elecciones. Un debate cuyo punto de partida, a su vez, constó de dos condicionantes principales: primero, las diferentes estrategias informativas de Gobierno y oposición, así como los diversos medios de comunicación, en cuanto a la autoría del atentado, y segundo, la sobreinformación del público, a través tanto de los medios de comunicación de masas tradicionales como de medios de información alternativos (televisiones por cable, canales temáticos, la Internet) e interpersonales (principa…

Olympialaisten arvot ja tarinoiden taustat : Ateenan 2004 kisojen TV-lähetysten analysointia greimasilaisessa viitekehyksessä

2006

The timing of initial imaging in testicular cancer: impact on radiological findings and clinical decision making

2021

Background In testicular cancer determination of clinical stage and recommendation of therapeutic strategy after inguinal orchiectomy are based on primary imaging by CT-scan of the chest and CT- or MRI- abdomen. It has not been investigated so far, whether the imaging should be performed before or after primary testicular surgery. Staging before surgery means exposing all patients to CT radiation irrespective of ensured histologic malignancy while postoperative staging could pose a risk in biased clinical decision making by increased presence of unspecific lymph node enlargement caused by postsurgical effects. Therefore, we aimed to investigate the association between the timing of initial …

Measurement of acoustic attenuation in South Pole ice

2010

Using the South Pole Acoustic Test Setup (SPATS) and a retrievable transmitter deployed in holes drilled for the IceCube experiment, we have measured the attenuation of acoustic signals by South Pole ice at depths between 190 m and 500 m. Three data sets, using different acoustic sources, have been analyzed and give consistent results. The method with the smallest systematic uncertainties yields an amplitude attenuation coefficient alpha = 3.20 \pm 0.57 km^(-1) between 10 and 30 kHz, considerably larger than previous theoretical estimates. Expressed as an attenuation length, the analyses give a consistent result for lambda = 1/alpha of ~1/300 m with 20% uncertainty. No significant depth or …