Search results for "010404 medicinal & biomolecular chemistry"

showing 3 items of 373 documents

Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation

2020

Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm formation is recognized as one of the most relevant. Considering the high and growing percentage of multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable of counteracting the formation of biofilms are urgently required. In this scenario, a new series of 18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilm formation against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923 and S. aureus ATCC 6538 a…

thiazole derivativeAquatic OrganismsStaphylococcus aureusIndolesantibiotic resistanceSettore BIO/05 - ZoologiaPharmaceutical ScienceMicrobial Sensitivity TestsBacterial growthSettore BIO/19 - Microbiologia Generalemedicine.disease_cause01 natural sciencesArticlenortopsentinAnalytical ChemistryMicrobiologylcsh:QD241-441Inhibitory Concentration 50chemistry.chemical_compoundAlkaloidsAntibiotic resistancelcsh:Organic chemistryDrug DiscoverymedicinePhysical and Theoretical ChemistryThiazoleStrain (chemistry)010405 organic chemistryPseudomonas aeruginosamarine alkaloids analoguesAlkaloidOrganic ChemistryImidazolesBiofilmantibiofilm agentsSettore CHIM/08 - Chimica Farmaceuticamarine alkaloids analogueantibiofilm agent0104 chemical sciencesThiazoles010404 medicinal & biomolecular chemistrychemistryChemistry (miscellaneous)Staphylococcus aureusBiofilmsPseudomonas aeruginosathiazole derivativesMolecular MedicineMolecules
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Chemical Composition of the Essential Oil of Bupleurum Fontanesii (Apiaceae) Growing Wild in Sicily and its Activity on Microorganisms Affecting Hist…

2016

Hydrodistillation of the flowers (BpFl) of and fruits (BpFr) of Bupleurum fontanesii Guss. ex Caruel gave two oils that were analyzed by GC and GC-MS. The main components were α-elemol (16.7%), caryophyllene oxide (16.4%) and heptacosane (15.9%) in BpFl, and spathulenol (16.8%), caryophylladienol I (13.2%) and α-elemol (12.8%) in BpFr. A good antimicrobial activity against several microorganisms, including Bacillus subtilis, Staphylococcus aureus, Fusarium oxysporum and Aspergillus niger, all infesting historical art craft, was also determined.

α-ElemolBupleurumAntifungal AgentsMicroorganismPlant ScienceBacillus subtilis01 natural scienceslaw.inventionlawVolatile componentDrug DiscoveryBotanyFusarium oxysporumOils VolatilePlant OilsSicilyEssential oilPharmacologyApiaceaeBacteriaBupleurum fontanesiibiology010405 organic chemistryDrug Discovery3003 Pharmaceutical ScienceAspergillus nigerFungiSpathulenolfood and beveragesGeneral MedicineComplementary and Alternative Medicine2708 DermatologyAntimicrobialbiology.organism_classificationAnti-Bacterial AgentsBupleurum0104 chemical sciences010404 medicinal & biomolecular chemistryCaryophyllene oxideComplementary and alternative medicineArtApiaceaeNatural Product Communications
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Chemical composition and biological activity of the essential oil of Ballota hispanica (L.) Benth. growing wild in Sicily

2015

Ballota L. comprises several relevant species largely used for their excellent therapeutic properties. Ballota hispanica (L.) Benth. is widely used in herbal medicine, and it is sold in herbalist shops for its sedative and antispasmodic properties. Considering its traditional medicinal use and the lack of scientific studies on the volatile components of this species as well as on its biological activities, in this study the chemical composition of the essential oil from aerial parts of B. hispanica, collected in Sicily, was evaluated by gas chromatography and gas chromatography–mass spectrometry. α-Elemol was the most abundant component of the oil (10.9%), followed by α-ylangene (8.5%),…

α-elemolPlant Sciencefree radical scavenging activityBiology01 natural scienceslaw.inventionlawBotanymedicineMedicinal plantsChemical compositionEcology Evolution Behavior and SystematicsEssential oilantimicrobial activity010405 organic chemistryBiological activityAntimicrobialbiology.organism_classificationEcology Evolution Behavior and Systematic0104 chemical sciences010404 medicinal & biomolecular chemistryBallota hispanicaα-ylangeneComposition (visual arts)AntispasmodicBallotamedicine.drugPlant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
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