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showing 10 items of 793 documents

CCDC 1443023: Experimental Crystal Structure Determination

2016

Related Article: Pierre-Emmanuel Doulain, Christine Goze, Ewen Bodio, Philippe Richard, Richard A. Decréau|2016|Chem.Commun.|52|4474|doi:10.1039/C5CC10526A

N-(2-(55-Difluoro-5H-6lambda55lambda5-dipyrrolo[12-c:2'1'-f][132]diazaborinin-10-yl)phenyl)-4-(dimethylamino)benzamide ethyl acetate solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 938974: Experimental Crystal Structure Determination

2014

Related Article: Lena Kaufmann, Nora L. Traulsen, Andreas Springer, Hendrik V. Schröder, Toni Mäkelä, Kari Rissanen, Christoph A. Schalley|2014|Org.Chem.Front.|1|521|doi:10.1039/C4QO00077C

N-(2-(hexanoyl(methyl)amino)ethyl)-N-methylbenzamide 11'-iodo-5'17'23'35'38'40'43'45'-octamethyl-7'15'25'33'39'-pentaazadispiro[cyclohexane-12'-heptacyclo[32.2.2.2^36^.2^1619^.2^2124^.1^913^.1^2731^]hexatetracontane-20'1''-cyclohexane]-1'(36')3'5'9'(44')10'12'16'18'21'23'27'(39')28'30'34'37'40'42'45'-octadecaene-8'14'26'32'-tetroneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1982669: Experimental Crystal Structure Determination

2023

Related Article: Antonin Jaillet, Christophe Darcel, Jérôme Bayardon, Adrien Schlachter, Christine Salomon, Yoann Rousselin, Pierre Harvey, Sylvain Jugé|2020|J.Org.Chem.|85|14391|doi:10.1021/acs.joc.0c00536

N-Methyl((2-hydroxy-1-methyl-2-phenyl)ethyl)amino-(11'-binaphthalen-2-yl)(phenyl)phosphineboraneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1577820: Experimental Crystal Structure Determination

2018

Related Article: Zoran Džolić, Ngong Kodiah Beyeh, Mario Cetina, Lotta Turunen, Kari Rissanen|2018|Chem.Asian J.|13|164|doi:10.1002/asia.201701426

N1N1'N1''N1'''-{[2122232-tetraethyl-10203040-tetrahydroxy-5152535-tetraoxa-7172737-tetraazanonacyclo[31.7.1.1311.11321.12331.049.01419.02429.03439]tetratetraconta-1(41)3911(44)131921(43)232931(42)3339-dodecaene-7172737-tetrayl]tetrapropane-31-diyl}tetrakis(N2-phenylethanediamide) chloroform unknown solvate hemihydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myelo…

2022

Despite progressive advances in understanding the molecular biology of acute myeloid leukemia (AML), the conventional therapeutic approach has not changed substantially, and the outcome for most patients is poor. Thus, continuous efforts on the discovery of new compounds with improved features are required. Following a multistep sequence, we have identified a new tetracyclic ring system with strong antiproliferative activity towards several haematological cell lines. The new compounds possess structural properties typical of inactive-state-binding kinase inhibitors and are structurally related to quizartinib which is known as type-II tyrosine kinase inhibitor. In particular, the high activi…

PharmacologyFMS-like tyrosine kinase 3 (FLT3)FLT3/ITD3][13]thiazolo[4Organic Chemistry2H-imidazo [2′1':23][13]thiazolo[45-e]isoindol-8-yl-phenylureas2H-imidazo [2′1':23][13]thiazolo[45-e]isoindol-8-yl-phenylureas; Acute myeloid leukemia (AML); FLT3/ITD; FMS-like tyrosine kinase 3 (FLT3); Internal tandem duplication (ITD)ApoptosisGeneral Medicine2H-imidazo [2′Leukemia Myeloid AcuteMiceInternal tandem duplication (ITD)fms-Like Tyrosine Kinase 35-e]isoindol-8-yl-phenylureasCell Line TumorDrug DiscoveryMutationAcute myeloid leukemia (AML)AnimalsHumansProtein Kinase Inhibitors1':2European journal of medicinal chemistry
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CCDC 263681: Experimental Crystal Structure Determination

2005

Related Article: D.Schollmeyer, R.Hoffmann, J.Mattay|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o290|doi:10.1107/S1600536805000140

Space GroupCrystallography(-)-(3a'S4'S9b'S1R2S5R)-4'-Ethyl-3a'4'5'7'8'9b'-hexahydro-2-isopropyl-5-methyl-2'-phenylspiro(cyclohexane-17'-dioxino(32-e)isoindole)-1'3'9'-trioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1425265: Experimental Crystal Structure Determination

2016

Related Article: T. Mäkelä, K. Rissanen|2016|Dalton Trans.|45|6481|doi:10.1039/C6DT00414H

Space GroupCrystallography(11'-(2356891112-Octahydro-1471013-benzopentaoxacyclopentadecine-1516-diyl)bis(3-(4-nitrophenyl)urea)-OO'O''O'''O''')-(11'-(2356891112-octahydro-1471013-benzopentaoxacyclopentadecine-1516-diyl)bis(3-(4-nitrophenyl)urea)-OO'O''O''')-potassium bromide NN-dimethylformamide solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1983787: Experimental Crystal Structure Determination

2020

Related Article: Tuan‐Anh Nguyen, Julien Roger, Houssein Nasrallah, Vincent Rampazzi, Sophie Fournier, Hélène Cattey, E. Daiann Sosa Carrizo, Paul Fleurat‐Lessard, Charles H. Devillers, Nadine Pirio, Dominique Lucas, Jean‐Cyrille Hierso|2020|Chem.Asian J.|15|2879|doi:10.1002/asia.202000579

Space GroupCrystallography(11'-bis(diphenylphosphino)-33'-di-t-butylferrocene)-iodo-gold(i) dichloromethane unknown solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 800788: Experimental Crystal Structure Determination

2011

Related Article: Hyui Sul Lee, M.Niemeyer|2011|Inorg.Chim.Acta|374|163|doi:10.1016/j.ica.2011.01.079

Space GroupCrystallography(1-(2'4'6'-triisopropylbiphenyl-2)-3-(2462''4''6''-hexamethyl-11':3'1''-terphenyl-2')triazenido)-(t-butylisonitrile)-copper(i) benzene solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1017369: Experimental Crystal Structure Determination

2014

Related Article: K. Chandralekha, D. Gavaskar, A.R. Sureshbabu, S. Lakshmi|2014|Acta Crystallogr.,Sect.E:Struct.Rep.Online|70|124|doi:10.1107/S1600536814017644

Space GroupCrystallography(2'-Ferrocenyl-1'2'5'6'7'7a'-hexahydrospiro[indeno[12-b]quinoxaline-113'-pyrrolizin]-1'-yl)(4-methylphenyl)methanoneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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