Search results for "1103"
showing 10 items of 538 documents
Topological Dual Systems for Spaces of Vector Measure p-Integrable Functions
2016
[EN] We show a Dvoretzky-Rogers type theorem for the adapted version of the q-summing operators to the topology of the convergence of the vector valued integrals on Banach function spaces. In the pursuit of this objective we prove that the mere summability of the identity map does not guarantee that the space has to be finite dimensional, contrary to the classical case. Some local compactness assumptions on the unit balls are required. Our results open the door to new convergence theorems and tools regarding summability of series of integrable functions and approximation in function spaces, since we may find infinite dimensional spaces in which convergence of the integrals, our vector value…
Demand Sharing Inaccuracies in Supply Chains: A Simulation Study
2018
We investigate two main sources of information inaccuracies (i.e., errors and delays) in demand information sharing along the supply chain (SC). Firstly, we perform a systematic literature review on inaccuracy in demand information sharing and its impact on supply chain dynamics. Secondly, we model several SC settings using system dynamics and assess the impact of such information inaccuracies on SC performance. More specifically, we study the impact of four factors (i.e., demand error, demand delay, demand variability, and average lead times) using three SC dynamic performance indicators (i.e., bullwhip effect, inventory variability, and average inventory). The results suggest that demand …
A new compact formulation for the discrete p-dispersion problem
2017
Abstract This paper addresses the discrete p -dispersion problem (PDP) which is about selecting p facilities from a given set of candidates in such a way that the minimum distance between selected facilities is maximized. We propose a new compact formulation for this problem. In addition, we discuss two simple enhancements of the new formulation: Simple bounds on the optimal distance can be exploited to reduce the size and to increase the tightness of the model at a relatively low cost of additional computation time. Moreover, the new formulation can be further strengthened by adding valid inequalities. We present a computational study carried out over a set of large-scale test instances i…
The value of open-source clinical science in pandemic response
2021
International audience
Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel
2015
Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin-associated muscle symptoms (SAMS), and avoided the use of the term 'statin intolerance'. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10 - 15% of patients. In clinical practice, statin intolerance limits effecti…
Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study.
2021
Abstract Background and aims Central and Eastern Europe (CEE) is a largely understudied region, despite having the highest cardiovascular disease mortality in Europe. This analysis aimed to assess the proportion of patients in CEE who achieved their LDL-C goals based on individual cardiovascular risk recommended by the 2016 and 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines. Methods The DA VINCI study was a cross-sectional observational study of primary and secondary prevention patients receiving lipid-lowering therapy across Europe between June 2017 and November 2018. Results In total, 2154 patients were enrolled from the Czech Republic (n = 509…
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
2021
Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds…
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23
2021
Abstract Aims Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause of systolic heart failure. Methods and results We conducted the largest genome-wide association study performed so far in DCM, with 2719 cases and 4440 controls in the discovery population. We identified and replicated two new DCM-associated loci on chromosome 3p25.1 [lead single-nucleotide polymorphism (SNP) rs62232870, P = 8.7 × 10−11 and 7.7 × 10−4 in the discovery and replication steps, respectively] and chromosome 22q11.23 (lead SNP rs7284877, P = 3.3 × 10−8 and 1.4 × 10−3 in the discovery and replication steps, respectively), while confirming two previously identif…
Current knowledge of pituitary adenylate cyclase activating polypeptide (PACAP) in articular cartilage
2020
Pituitary adenylate cyclase activating polypeptide (PACAP) is an evolutionally well conserved neuropeptide, mainly expressed by neuronal and peripheral cells. It proves to be an interesting object of study both for its trophic functions during the development of several tissues and for its protective effects against oxidative stress, hypoxia, inflammation and apoptosis in different degenerative diseases. This brief review summarises the recent findings concerning the role of PACAP in the articular cartilage. PACAP and its receptors are expressed during chondrogenesis and are shown to activate the pathways involved in regulating cartilage development. Moreover, this neuropeptide proves to be…
Maximum weight relaxed cliques and Russian Doll Search revisited
2015
Trukhanov et al. [Trukhanov S, Balasubramaniam C, Balasundaram B, Butenko S (2013) Algorithms for detecting optimal hereditary structures in graphs, with application to clique relaxations. Comp. Opt. and Appl., 56(1), 113–130] used the Russian Doll Search (RDS) principle to effectively find maximum hereditary structures in graphs. Prominent examples of such hereditary structures are cliques and some clique relaxations intensely discussed and studied in network analysis. The effectiveness of the tailored RDS by Trukhanov et al. for s-plex and s-defective clique can be attributed to their cleverly designed incremental verification procedures used to distinguish feasible from infeasible struct…