Search results for "1103"
showing 10 items of 538 documents
The Hierarchical Mixed Rural Postman Problem: Polyhedral analysis and a branch-and-cut algorithm
2017
[EN] The Hierarchical Mixed Rural Postman Problem is defined on a mixed graph where arcs and edges that require a service are divided into clusters' that have to be serviced in a hierarchical order. The problem generalizes the Mixed Rural Postman Problem and thus is NP-hard. In this paper, we provide a polyhedral analysis of the problem and propose a branch-and-cut algorithm for its solution based on the introduced classes of valid inequalities. Extensive computational experiments are reported on benchmark instances. The exact approach allows to find the optimal solutions in less than 1 hour for instances with up to 999 vertices, 2678 links, and five clusters.
Optimizing the level of service quality of a bike-sharing system
2016
Public bike-sharing programs have been deployed in hundreds of cities worldwide, improving mobility in a socially equitable and environmentally sustainable way. However, the quality of the service is drastically affected by imbalances in the distribution of bicycles among stations. We address this problem in two stages. First, we estimate the unsatisfied demand (lack of free lockers or lack of bicycles) at each station for a given time period in the future and for each possible number of bicycles at the beginning of the period. In a second stage, we use these estimates to guide our redistribution algorithms. Computational results using real data from the bike-sharing system in Palma de Mall…
Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collabora…
2018
PubMed: 30270054
Capturing citizens — Emerging needs: Using social networks in smart cities
2017
In order to reach its objectives, smart cities (or whatever kind of smart urban environment) should be underpinned by complex cyber physical systems (CPS) able to discover needs and services and "smartly" combine them. Services may be thought as services offered by software components, of whatever nature, for instance software, bot, robot, app and so on. Searching for the best service depends on the need of the citizen(s) and also on the type of (smart) environment the citizens are in. Analysis and design of CPSs are more challenging than the only physical or the only cyber system. We propose a design paradigm shift towards runtime for identifying requirements of cyber physical systems for …
An affine scaling method using a class of differential barrier functions: primal approach
2020
International audience; In this paper we propose a family of affine scaling interior point algorithms, called galpv4, using a primal approach, based on a large class of differential barrier functions. We show that these algorithms are in fact an extension and generalization of the classical affine scaling algorithm based on the well-known log barrier function. After carrying out a complete convergence analysis, we select some of these algorithms for comparison with the classical affine scaling algorithm, performed with the help of the familiar Netlib test set.
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.
2021
[BACKGROUND & AIMS] Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. [METHODS] We combined new and existing genotype data for 10, 516 cases and 20, 77…
Genetic prediction of ICU hospitalization and mortality in COVID‐19 patients using artificial neural networks
2021
There is an unmet need of models for early prediction of morbidity and mortality of Coronavirus disease-19 (COVID-19). We aimed to a) identify complement-related genetic variants associated with the clinical outcomes of ICU hospitalization and death, b) develop an artificial neural network (ANN) predicting these outcomes and c) validate whether complement-related variants are associated with an impaired complement phenotype. We prospectively recruited consecutive adult patients of Caucasian origin, hospitalized due to COVID-19. Through targeted next-generation sequencing, we identified variants in complement factor H/CFH, CFB, CFH-related, CFD, CD55, C3, C5, CFI, CD46, thrombomodulin/THBD, …
Participation and performance trends in 100-km ultra-marathons worldwide
2014
The aims of the present study were to (1) investigate the participation trends for the origin of athletes competing in 100-km ultra-marathons and (2) determine the nationalities of athletes achieving the fastest 100-km race times worldwide. Race times and nationality from 112,283 athletes (15,204 women and 97,079 men) from 102 countries who completed a 100-km ultra-marathon worldwide between 1998 and 2011 were investigated using single- and multi-level regression analyses. The number of finishers increased exponentially, both for women and men. Most of the finishers (73.5%) were from Europe, in particular, France (30.4%). The number of finishers from Japan, Germany, Italy, Poland and the Un…
European athletes dominate performances in Double Iron ultra-triathlons - A retrospective data analysis from 1985 to 2010
2014
International audience; We investigated the participation and performance trends of ultra-endurance triathletes from all nationalities competing in a Double Iron ultra-triathlon (7.6-km swim, 360-km cycle and 84.4-km run) from 1985 to 2010. A total of 1854 athletes participated in 92 Double Iron ultra-triathlons. The majority of the winners came from Europe with 72 victories, followed by North America with 17 victories. The race time for the European ultra-triathletes was 1340 (s=95.3) min, decreasing highly significantly (r(2)=0.28; P<0.0001) across the years. North American ultra-triathletes finished the races within 1556 (s=124.5) min; their race time showed no changes across the years (…
''Limits in endurance performance of octogenarian athletes''
2013
TO THE EDITOR: A recent study of Trappe et al. (3) showed that the aerobic power of octogenarian lifelong endurance athletes was approximately double that of untrained octogenarians (38 vs. 21 ml·kg 1 ·min 1 ). These remarkable aerobic capacities are the highest ever recorded in this age group. However, the impact of the identified physiological capacities on actual endurance performances has not been addressed, as no running performance indicators of the octogenarian athletes were provided in this study. We hereby suggest that, although trained octogenarian athletes can achieve levels of aerobic fitness well above their untrained counterpart, as a group they actually have not yet reached t…