Search results for "11b"
showing 3 items of 43 documents
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
2004
Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens and has also emerged as a hallmark of vascular inflammation. One of the principal enzymes released upon PMN activation is myeloperoxidase (MPO), a heme protein that not only generates cytotoxic oxidants but also impacts deleteriously on nitric oxide-dependent signaling cascades within the vasculature. Because MPO also associates with the membrane of PMN, we evaluated whether MPO could also function as an autocrine modulator of PMN activation. The extent of PMN membrane-associated MPO was elevated in patients with acute inflammatory vascular disease compared with…
Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis
2007
Abstract The transcription factor STAT4 mediates signals of various proinflammatory cytokines, such as IL-12, IL-15, and IL-23, that initiate and stabilize Th1 cytokine production. Although Th1 cytokine production has been suggested to play a major pathogenic role in rheumatoid arthritis, the role of STAT4 in this disease is poorly understood. In this study, we demonstrate a key functional role of STAT4 in murine collagen-induced arthritis (CIA). In initial studies we found that STAT4 expression is strongly induced in CD4+ T cells and to a lesser extent in CD11b+ APCs during CIA. To analyze the role of STAT4 for arthritis manifestation, we next investigated the outcome of interfering with S…
On arithmetic sums of Ahlfors-regular sets
2021
Let $A,B \subset \mathbb{R}$ be closed Ahlfors-regular sets with dimensions $\dim_{\mathrm{H}} A =: \alpha$ and $\dim_{\mathrm{H}} B =: \beta$. I prove that $$\dim_{\mathrm{H}} [A + \theta B] \geq \alpha + \beta \cdot \tfrac{1 - \alpha}{2 - \alpha}$$ for all $\theta \in \mathbb{R} \, \setminus \, E$, where $\dim_{\mathrm{H}} E = 0$.