Search results for "122"
showing 10 items of 205 documents
ADC measurements in diffuse large B-cell lymphoma and follicular lymphoma: a DWI and cellularity study.
2012
Diffusion-weighted magnetic resonance imaging (DW-MRI) allows quantifying the random motion of water molecules in tissue by means of apparent diffusion coefficient (ADC) measurements. The aim of the study was to determine whether ADC measurements allow discrimination of diffuse large B-cell lymphoma (DLBCL) from follicular lymphoma (FL), and to examine the relationship between cellularity and ADC value of the tumor using DWI.Thirty-two patients with histologically proven non-Hodgkin lymphoma (21 with DLBCL and 11 with FL, 17 males and 15 females, mean age 62±13 years) underwent conventional MRI and DWI examination before treatment. The ADC values of DLBCL were compared to those of FL. The A…
Identification of multiplicatively acting modulatory mutational signatures in cancer
2022
Abstract Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build such understanding. They capture somatic mutation patterns and at best identify their causes. Most studies in this context have focused on an inherently additive analysis, e.g. by non-negative matrix factorization, where the mutations within a cancer sample are explained by a linear combination of independent mutational signatures. However, other recent studies show that the mutational signatures exhibit non-additive interactions. Resu…
From pedologic indications to archaeological reconstruction: deciphering land use in the Islamic period in the Baida district (north-western Sicily)
2013
Abstract The aim of this work was to detect imprints on soil properties from former Islamic land use (9th to 11th century) using a multi-method, soil-chemical approach. Four soil profiles (with buried horizons) found in the vicinities of former Islamic settlements in Sicily were analysed for phosphorus (total, organic and inorganic), nitrogen (total, NO 3 − and NH 4 + ), carbon compounds (δ 13 C, lipids, polycyclic aromatic hydrocarbons (PAH) and functional groups), physical and chemical C-fractions and the state of soil weathering. Two soil profiles contained ceramic sherds from the Islamic period. Inorganic nitrogen forms, phosphorous and the PAH content indicated strong impacts from trad…
Traitement de données RGB et Lidar à extrêmement haute résolution: retombées de la compétition de fusion de données 2015 de l'IEEE GRSS - Partie A / …
2016
International audience; In this paper, we discuss the scientific outcomes of the 2015 data fusion contest organized by the Image Analysis and Data Fusion Technical Committee (IADF TC) of the IEEE Geoscience and Remote Sensing Society (IEEE GRSS). As for previous years, the IADF TC organized a data fusion contest aiming at fostering new ideas and solutions for multisource studies. The 2015 edition of the contest proposed a multiresolution and multisensorial challenge involving extremely high-resolution RGB images and a three-dimensional (3-D) LiDAR point cloud. The competition was framed in two parallel tracks, considering 2-D and 3-D products, respectively. In this paper, we discuss the sci…
Trends in phenological parameters and relationship between land surface phenology and climate data in the Hyrcanian forests of Iran
2017
Vegetation activity may be changed in response to climate variability by affecting seasonality and phenological events. Monitoring of land surface phenological changes play a key role in understanding feedback of ecosystem dynamics. This study focuses on the analysis of trends in land surface phenology derived parameters using normalized difference vegetation index time series based on Global Inventory Monitoring and Mapping Studies data in the Hyrcanian forests of Iran covering the period 1981–2012. First, we applied interpolation for data reconstruction in order to remove outliers and cloud contamination in time series. Phenological parameters were retrieved by using the midpoint approach…
Trauma and storytelling in Betty Louise Bell’s Faces in the Moon
2018
The dominant understanding of trauma as an epistemological crisis that can be mimetically passed on to readers has in the twenty-first century been criticized for its apolitical and ahistorical ori...
Chronografia sagrada de la vida de Christo nuestro Redemptor, predicacion Evangelica, con las circunstancias de lugar, y tiempo en que obrò los Mist…
1696
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The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance
2021
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alon…
Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial : Planned 10-Year Follow-up
2022
Abstract The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with Lynch syndrome (LS). Participants with LS were randomized double-blind to 30 g resistant starch (RS) daily or placebo for up to 4 years. We present long-term cancer outcomes based on the planned 10-year follow-up from recruitment, supplemented by National Cancer Registry data to 20 years in England, Wales, and Finland. Overall, 463 participants received RS and 455 participants received placebo. After up to 20 years follow-up, there was no difference in colorectal cancer incidence (n = 52 diagnosed with colorectal cancer among those randomized to RS against n = 53…
Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based study
2019
Colorectal carcinomas that are mismatch repair (MMR)‐deficient in the absence of MLH1 promoter methylation or germline mutations represent Lynch‐like syndrome (LLS). Double somatic events inactivating MMR genes are involved in the etiology of LLS tumors. Our purpose was to define the clinical and broader molecular hallmarks of LLS tumors and the population incidence of LLS, which remain poorly characterized. We investigated 762 consecutive colorectal carcinomas operated in Central Finland in 2000–2010. LLS cases were identified by a stepwise protocol based on MMR protein expression, MLH1 methylation and MMR gene mutation status. LLS tumors were profiled for CpG Island Methylator Phenotype (…