Search results for "124"
showing 10 items of 329 documents
Neural Stem Cells in the Adult Brain: From Benchside to Clinic
2012
Increasing evidence indicates that neural stem cells (NSCs) play an important role in sustaining cellular homeostasis and brain tissue restoration. The study of all mechanisms that control and modulate the function of NSC is a crucial step for the design of therapies against chronic neurodegenerative processes. In this special issue of the journal, we had the pleasure to edit the topic entitled “Neural Stem Cells in the Adult Brain: From Benchside to Clinic.” This special compilation of paper was aimed to provide a global forum for publications of original peer-reviewed manuscripts that reported original research findings in the field of adult neural stem cell, including short communication…
Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies
2011
The potent anti-tumor activities of γδ T cells, their ability to produce pro-inflammatory cytokines, and their strong cytolytic activity have prompted the development of protocols in which γδ agonists or ex vivo-expanded γδ cells are administered to tumor patients. γδ T cells can be selectively activated by either synthetic phosphoantigens or by drugs that enhance their accumulation into stressed cells as aminobisphosphonates, thus offering new avenues for the development of γδ T cell-based immunotherapies. The recent development of small drugs selectively activating Vγ9Vδ2 T lymphocytes, which upregulate the endogenous phosphoantigens, has enabled the investigators to design the experiment…
Low molecular weight heparins in cancer patients: to treat thromboembolic events, the tumor, or both?
2011
The interrelationship between cancer and thrombosis is well known. Recent data help physicians to optimize the management of thrombotic complications occurring in cancer patients. However, many issues are still uncertain. First, although the development of venous thromboembolism (VTE) in a patient with known cancer is the most common presentation, concerns remain about the optimal duration and dosages of anticoagulants. Questions also arise concerning the need to implement heparin prophylaxis in the course of chemotherapy. Secondly, in some patients, thrombosis precedes the diagnosis of malignancy. In this case, the question is whether or not to screen patients for an occult cancer. Thirdly…
Overweight Adolescents’ Self-Perceived Weight and Weight Control Behaviour: HBSC Study in Finland 1994–2010
2012
Introduction. Overweight and perception of being overweight, may lead adolescent to lose weight. The aim of the present study was to investigate overweight adolescents’ self-perceived weight, body dissatisfaction, and weight control behaviour during 1994–2010 in Finland.Methods. The country-representative, cross-sectional data of 15-year olds were obtained from the Health Behaviour in School-aged Children (HBSC) study, conducted in 1994 (; males: 48%), 1998 (; 49%), 2002 (; 50%), 2006 (; 47%), and 2010 (; 48%).Results. The majority of overweight boys (62–69%) and girls (89–100%) assessed themselves as too fat, and their body image was lower than in nonoverweight adolescents. The highest pre…
Advanced chronic kidney disease. Association between anxiety, depression and resilience
2019
Resumen Introducción: el padecimiento de la enfermedad renal crónica avanzada (ERCA) se asocia con una mayor probabilidad de padecer sintomatología depresiva y ansiosa. No obstante, la resiliencia puede amortiguar estos efectos. El objetivo general fue valorar la sintomatología ansiosa, depresiva y la resiliencia de los pacientes con ERCA. Métodos: 70 pacientes (80 % varones), con edades entre 38-88 años (M=68,88; DT= 9,98) fueron evaluados mediante la Escala Hospitalaria de Ansiedad y Depresión y la de Resiliencia de Connor Davidson. Se realizaron análisis descriptivos, pruebas t, d de Cohen y correlaciones de Pearson. Resultados: un 41,79 % presentó sintomatología ansiosa y un 25,38 % dep…
Age of peak performance in elite male and female Ironman triathletes competing in Ironman Switzerland, a qualifier for the Ironman world championship…
2012
Christoph Alexander Rüst,1 Beat Knechtle,1,2 Patrizia Knechtle,2 Thomas Rosemann,1 Romuald Lepers31Institute of General Practice and for Health Services Research, University of Zurich, 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: The age of peak performance in elite endurance athletes has been investigated for elite marathoners, but not for elite Ironman triathletes. The aim of this study was to analyze the age of peak performance in swimming (3.8 km), cycling (180 km), running (42 km), and overall race time for elite female and male Ironman triathletes competing in Ironman Switzerl…
Central European triathletes dominate Double Iron ultratriathlon – analysis of participation and performance 1985–2011
2012
Katrin Sigg,1 Beat Knechtle,1,2 Christoph Alexander Rüst,1 Patrizia Knechtle,2 Romuald Lepers,3 Thomas Rosemann11Institute of General Practice and Health Services Research, University of Zurich, Zurich; 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: A recent study showed that European triathletes performed faster in Double Iron ultratriathlons than North American athletes. The present study analyzed triathletes participating in Double Iron ultratriathlons to determine the origin of the fastest Double Iron ultratriathletes, focusing on European countries.Methods: Participation and perf…
A comparison of medley and freestyle performance for national and international swimmers between 1994 and 2011
2013
Christof Buhl,1 Beat Knechtle,1,2 Christoph Alexander Rüst,1 Thomas Rosemann,1 Romuald Lepers31Institute of General Practice and for Health Services Research, University of Zurich, Zurich, Switzerland; 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3Faculty of Sport Sciences, University of Burgundy, Dijon, FranceAbstract: The change in swim performance over time has been investigated for freestyle, but not for other strokes, such as in the medley. The aim of the study was to examine changes in 200 m and 400 m swim performances in medley swimmers at national (Switzerland) and international level (world championship finals) from 1994 to 2011. The 200 m and 400 m freestyle perform…
Age and gender differences in half-Ironman triathlon performances – the Ironman 70.3 Switzerland from 2007 to 2010
2012
Beat Knechtle,1,2 Christoph Alexander Rüst,2 Thomas Rosemann,2 Romuald Lepers31Gesundheitszentrum St Gallen, St Gallen, Switzerland; 2Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: To date, the age-related decline and gender differences in performance have been investigated for both Olympic and Ironman distance triathlons, but not for the intermediate distance (ie, the half-Ironman distance triathlon covering 1.9 km swimming, 90 km cycling and 21.1 km running, Ironman 70.3®). We determined the age-related differences in performan…
Age and sex interactions in mountain ultramarathon running – the Swiss Alpine Marathon
2012
Evelyn Eichenberger,1 Beat Knechtle,1,2 Christoph Alexander Rüst,1 Thomas Rosemann,1 Romuald Lepers31Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland; 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: The aims of the study were to examine the (a) participation, (b) difference in running times between the sexes, and (c) age-related decline in the running times of ultramarathoner women and men competing in the Swiss Alpine Marathon from 1998 to 2011.Methods: The ultramarathoners competing in the Swiss Alpine Marathon were analyzed in ter…