Search results for "129"

sj-docx-1-dhj-10.1177_20552076221074485 - Supplemental material for The role of age and digital competence on the use of online health and social car…

2022

Supplemental material, sj-docx-1-dhj-10.1177_20552076221074485 for The role of age and digital competence on the use of online health and social care services: A cross-sectional population-based survey by T Heponiemi, A-M Kaihlanen, A Kouvonen, L Leemann, S Taipale and K Gluschkoff in Digital Health

Variable X-ray emission from the accretion shock in the classical T Tauri star V2129 Ophiuchi

2011

The soft X-ray emission from high density plasma in CTTS is associated with the accretion process. It is still unclear whether this high density cool plasma is heated in the accretion shock, or if it is coronal plasma fed/modified by the accretion process. We conducted a coordinated quasi-simultaneous optical and X-ray observing campaign of the CTTS V2129 Oph (Chandra/HETGS data to constrain the X-ray emitting plasma components, and optical observations to constrain the characteristics of accretion and magnetic field). We analyze a 200 ks Chandra/HETGS observation of V2129 Oph, subdivided into two 100 ks segments, corresponding to two different phases within one stellar rotation. The X-ray …

sj-pdf-1-smo-10.1177_20503121211019889 – Supplemental material for The efficacy of single suture for exit site wound closure and stabilization of hem…

2021

Supplemental material, sj-pdf-1-smo-10.1177_20503121211019889 for The efficacy of single suture for exit site wound closure and stabilization of hemodialysis central tunneled catheter by Tomasz Porazko, Andrzej Piersiak and Marian Klinger in SAGE Open Medicine

sj-pdf-1-smo-10.1177_20503121211019889 – Supplemental material for The efficacy of single suture for exit site wound closure and stabilization of hem…

2021

Supplemental material, sj-pdf-1-smo-10.1177_20503121211019889 for The efficacy of single suture for exit site wound closure and stabilization of hemodialysis central tunneled catheter by Tomasz Porazko, Andrzej Piersiak and Marian Klinger in SAGE Open Medicine

Las nuevas formas de movilidad de la población, la especificidad de la familia italiana y la explosión del coronavirus en Lombardía

2021

Encapsulation of xenon by bridged resorcinarene cages with high 129Xe NMR chemical shift and efficient exchange dynamics

2023

Functionalized cages encapsulating xenon atoms enable highly sensitive, background-free molecular imaging through a technique known as HyperCEST 129Xe MRI. Here, we introduce a class of potential biosensor cage structures based on two resorcinarene macrocycles bridged either by aliphatic carbon chains or piperazines. First-principles-based modeling predicts a high chemical shift (about 345 ppm) outside the typical experimental observation window for 129Xe encapsulated by the aliphatically bridged cage and two 129Xe resonances for the piperazine-bridged cages corresponding to single and double loading. Based on the computational predictions as well as 129Xe chemical exchange saturation trans…

Perlecan Maintains microvessel integrity in vivo and modulates their formation in vitro

2012

Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan. We found that perlecan was dispensable for blood vessel formation and maturation until embryonic day (E) 12.5. At later stages of development 40% of mutant embryos showed dilated microvessels in brain and skin, which ruptured and led to severe bleedings. Surprisingly, teratomas derived from perlecan-null ES cells showed efficient contribution of perlecan-deficient endothelial cells to an apparently normal tumor vasculature. However, in perlecan…

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

2019

Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural ne…

Mating systems and protein–protein interactions determine evolutionary rates of primate sperm proteins

2013

To assess the relative impact of functional constraint and post-mating sexual selection on sequence evolution of reproductive proteins, we examined 169 primate sperm proteins. In order to recognize potential genome-wide trends, we additionally analysed a sample of altogether 318 non-reproductive (brain and postsynaptic) proteins. Based on cDNAs of eight primate species (Anthropoidea), we observed that pre-mating sperm proteins engaged in sperm composition and assembly show significantly lower incidence of site-specific positive selection and overall lower non-synonymous to synonymous substitution rates ( d N / d S ) across sites as compared with post-mating sperm proteins involved in capac…

RORC1 Regulates Tumor-Promoting "Emergency" Granulo-Monocytopoiesis

2015

Cancer-driven granulo-monocytopoiesis stimulates expansion of tumor promoting myeloid populations, mostly myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). We identified subsets of MDSCs and TAMs based on the expression of retinoic-acid-related orphan receptor (RORC1/RORγ) in human and mouse tumor bearers. RORC1 orchestrates myelopoiesis by suppressing negative (Socs3 and Bcl3) and promoting positive (C/EBPβ) regulators of granulopoiesis, as well as the key transcriptional mediators of myeloid progenitor commitment and differentiation to the monocytic/macrophage lineage (IRF8 and PU.1). RORC1 supported tumor-promoting innate immunity by protecting MDSCs from …