Search results for "132"
showing 10 items of 114 documents
Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-…
2002
This report is focused on the apoptotic effect induced by MG132, an inhibitor of 26S proteasome, in human hepatoma HepG2 cells. The results were compared with those obtained with non-transformed human Chang liver cells. MG132 reduced the viability of HepG2 cells in a time- and dose-dependent manner. The effect was in tight connection with the induction of apoptosis, as indicated by fluorescence microscopy and cytometric analysis, and was accompanied by a remarkable increase in the production of H2O2 and a reduction in mitochondrial transmembrane potential (Deltapsim). In addition cell death was prevented by antioxidants such as GSH, N-acetylcysteine or catalase. Western blot analysis showed…
Arte, Música y Conceptualismo en América Latina
2021
Se investiga la relación entre el arte y la música desde el conceptualismo, que valida la existencia de un arte sonoro y de una música conceptuales, cuyas estéticas se alejan de la percepción coclear, para enfocarse en el campo de las ideas. Se sientan los antecedentes y se analiza el desarrollo de estos campos en occidente (Europa y Estados Unidos de América) desde las vanguardias del siglo XX hasta los años 60, para luego hacer una cartografía de la historia del conceptualismo sónico en Latino América desde los años 50 al presente, al redefinir, revalorar y contrastar las aportaciones que se han hecho en el continente, con un enfoque que se centra más en lo político y social, pero sin olv…
Pascale Jakubowski Instruments anciens et musique contemporaine
2021
NF-κB Is a Potential Molecular Drug Target in Triple-Negative Breast Cancers.
2017
Breast cancer continues to cause significant burden in global health morbidity and mortality. Triple-negative breast cancers (TNBCs) are highly aggressive with poor prognosis and are characterized by lack of expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor (Her-2). TNBCs are often resistant to cytotoxic chemotherapy and pose major difficulty in achieving personalized medicine due to their molecular heterogeneity. There is increasing evidence that the aberrant activation of nuclear factor (NF)-κB signaling is a frequent characteristic of TNBCs. We evaluated the effects of different potential NF-κB inhibitors, such as bisindolylmaleimide I (BI…
Radical innovation by theoretical abstraction - a challenge for the user-centred designer
2016
AbstractIt is generally accepted that scientific disciplines such as psychology, sociology, and anthropology contribute beneficially to design by providing understanding of users’ needs, experiences, and desires. Arguably, however, these disciplines have more to contribute, because they include theories and models that can be applied as design frames and principles. More specifically, goal-setting, visualization, thematization, and conceptual reconfiguration are general mechanisms through which theories translate into design contributions. Actualizing radical design solutions via these mechanisms is discussed: theories provide appropriate means of abstraction, which allows ‘distance’ from u…
The snail
2021
Liminaalitilan käsite työn muutosten jäsentäjänä
2013
Liminaalitila on antropologiassa määritelty välitilaksi, kynnyksellä olemiseksi. Liminaalisuus on nykypäivän työelämälle ominainen piirre, joka voi näyttäytyä kaaoksena, mutta myös uutta luovana muutosvaiheena.
Multianalytical Approach to explain the darkening process of hematite pigment in paintings from ancient Pompeii after accelerated weathering experime…
2013
[EN] In this paper, recently excavated fresco painting fragments from the House of Marcus Lucretius (Pompeii) and not exposed to the atmosphere since the eruption of the Mount Vesuvius were subjected to a controlled SO2 atmosphere and high relative humidity. These experiments were conducted in order to simulate under accelerated conditions the possible deterioration of the hematite pigment and plaster. The mineralogical transformation of the polychromy and plaster was monitored using mainly Raman spectroscopy, a non-destructive technique, but also infrared spectroscopy (FT-IR) and scanning electron microscopy energy-dispersive X-ray spectroscopy (SEM-EDS). After different exposure cycles to…
The Effect of Music on Movement Perception: Synchresis in Hits for HIIT
2021
Hits for HIIT consists in a research-creation project aiming to produce both musical pieces and training exercises for, on the one hand, optimizing HIIT practice and, on the other, enriching scholarly research on the relations between music and sports. These questions and their related studies have highlighted music/movement relations and the way they are perceived. In this paper we would like to outline how we attempt to build a two-way dialogue between the production of music adapted to HIIT and the design of workouts based on the music.