Search results for "132"
showing 10 items of 114 documents
Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor ce…
2010
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Celecoxib (Celebrex®) exhibits antitumor effects in human HCC cells, and its mechanism of action is mediated either by its ability to inhibit cyclooxygenase 2 (COX-2) or by a number of various other COX-2 independent effects. Proteasome inhibitors (PIs) can exert cell growth inhibitory and apoptotic effects in different tumor cell types, including HCC cells. The present study examined the interaction between celecoxib and the PI MG132 in two human liver tumor cell lines HepG2 and HA22T/VGH. Our data showed that each inhibitor reduced proliferation and induced apoptosis in a dose-dependen…
¿Por qué la literatura?
2021
In poetry, as well as in a good part of prose works, the rhythm of words is the music that governs reason and emotion. Literature occupies an important place in my creation. In this article I describe the different procedures in which I configure its presence in my music and the main themes in four of my works: Envoi, Como el viento, Maya and Transmutación.
La Méthode como hermenéutica musical Homenaje a Edgar Morin por su 100º cumpleaños
2021
The present work addresses the principles and properties of the complex thought formulated by the French thinker Edgar Morin and the way in which he was able me to articulate his conception of organizational complexity with one of the most important theories of musical analysis, which emerged at the beginning of the 20th century: the schenkerian analysis. It is a review and extension of a few pages of my doctoral thesis, which are intended to pay tribute to who has been, in addition to my teacher, Honorary President of Itamar since its first issue. His teachings and support has always been the engine for my quest for musical organization. On July 21, 2021, Morin celebrated his 100th birthda…
Forecasting future trajectories for immersive journalism
2021
In this book we have critically explored the emerging practices of immersive journalism. In the news business, experimenting with new forms of storytelling has become the new normal. After spending a decade to get familiar with simple virtual reality tools, however, the future of immersive journalism is still considered uncertain. Immersive storytelling appears to become more concentrated on special events and locations. Journalistic virtual reality skills are increasingly crafted away from the newsrooms by small and specialized subcontractors. Sponsoring VR by the big tech companies tends to diminish in parallel with a growing move towards augmented reality investments. peerReviewed
"Table 9" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"
2011
Pion HBT radii for the 5% most central collisions from the STAR experiment at 200 GeV taken from Adams et al. PR C71(2005)044906.
"Table 11" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"
2011
Ratio of Pion HBT radii for the OUT projection to that for the SIDE projection for the 5% most central collisions from the STAR experiment at 200 GeV taken from Adams et al. PR C71(2005)044906.;.
"Decay Phase-Space Volume of Partial Waves" of "Light isovector resonances in $\pi^- p \to \pi^-\pi^-\pi^+ p$ at 190 GeV/${\it c}$"
2018
Decay phase-space volume $I_{aa}$ for the 14 selected partial waves as a function of $m_{3\pi}$, normalized such that $I_{aa}(m_{3\pi} = 2.5~\text{GeV}/c^2) = 1$. The wave index $a$ represents the quantum numbers that uniquely define the partial wave. The quantum numbers are given by the shorthand notation $J^{PC} M^\varepsilon [$isobar$] \pi L$. We use this notation to label the decay phase-space volume in the column headers. The labels are identical to the ones used in the column headers of the table of the transition amplitudes. $I_{aa}$ is calculated using Monte Carlo integration techniques for fixed $m_{3\pi}$ values, which are given in the first column, in the range from 0.5 to 2.5 Ge…
"Transition Amplitudes" of "Light isovector resonances in $\pi^- p \to \pi^-\pi^-\pi^+ p$ at 190 GeV/${\it c}$"
2018
Real and imaginary parts of the normalized transition amplitudes $\mathcal{T}_a$ of the 14 selected partial waves in the 1100 $(m_{3\pi}, t')$ cells (see Eq. (12) in the paper). The wave index $a$ represents the quantum numbers that uniquely define the partial wave. The quantum numbers are given by the shorthand notation $J^{PC} M^\varepsilon [$isobar$] \pi L$. We use this notation to label the transition amplitudes in the column headers. The $m_{3\pi}$ values that are given in the first column correspond to the bin centers. Each of the 100 $m_{3\pi}$ bins is 20 MeV/$c^2$ wide. Since the 11 $t'$ bins are non-equidistant, the lower and upper bounds of each $t'$ bin are given in the column he…
NF-κB Inhibition Restores Sensitivity to Fas-Mediated Apoptosis in Lymphoma Cell Lines
2003
Failure to perform the Fas-related apoptosis pathway can account for tumor resistance both to chemotherapeutic agents and to immunological effectors. We studied the role of NK-kappaB in Fas-resistance, employing the Fas-sensitive human T-lymphoma HuT78 cell line and its Fas-resistant variants HuT78B1 and HuT78G9. All these cell lines expressed high levels of constitutively activated NF-kappaB. Pretreatment of cells with NF-kappaB inhibitors (PDTC, MG132, or SN50) strongly enhanced CH11-induced apoptosis in HuT78 and Hut78G9 cells, while only MG132 showed a similar potentiating effect in HuT78B1. The described synergism was significantly inhibited by pretreatment with the anti-Fas-blocking a…
Rapid shifting of a deep magmatic source at Fagradalsfjall volcano, Iceland
2022
AbstractRecent Icelandic rifting events have illuminated the roles of centralized crustal magma reservoirs and lateral magma transport1–4, important characteristics of mid-ocean ridge magmatism1,5. A consequence of such shallow crustal processing of magmas4,5 is the overprinting of signatures that trace the origin, evolution and transport of melts in the uppermost mantle and lowermost crust6,7. Here we present unique insights into processes occurring in this zone from integrated petrologic and geochemical studies of the 2021 Fagradalsfjall eruption on the Reykjanes Peninsula in Iceland. Geochemical analyses of basalts erupted during the first 50 days of the eruption, combined with associate…