Search results for "133"
showing 10 items of 144 documents
miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction
2014
Summary miR-133a and miR-1 are known as muscle-specific microRNAs that are involved in cardiac development and pathophysiology. We have shown that both miR-1 and miR-133a are early and progressively upregulated during in vitro cardiac differentiation of adult cardiac progenitor cells (CPCs), but only miR-133a expression was enhanced under in vitro oxidative stress. miR-1 was demonstrated to favor differentiation of CPCs, whereas miR-133a overexpression protected CPCs against cell death, targeting, among others, the proapoptotic genes Bim and Bmf. miR-133a-CPCs clearly improved cardiac function in a rat myocardial infarction model by reducing fibrosis and hypertrophy and increasing vasculari…
Therapeutic implications of Cancer Initiating Cells.
2009
Background: Until few years ago, all neoplastic cells within a tumour were suggested to have tumorigenic capacity, but recent evidences hint to the possibility that such feature is confined to a subset of Cancer Initiating Cells (CICs), also called Cancer Stem Cells (CSCs). These cells are the reservoir of the heterogeneous populations of differentiated cancer cells constituting the tumour bulk. Mechanisms shared with somatic stem cells, such as quiescence, self-renewal ability, asymmetric division and multidrug resistance, allow to these cells to drive tumour growth and to evade conventional therapy. Objective: Here, we give a brief overview on the origin of CICs, the mechanisms involved i…
Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.
2012
Abstract Tumor-initiating cells are responsible for tumor maintenance and relapse in solid and hematologic cancers. Although tumor-initiating cells were initially believed to be mainly quiescent, rapidly proliferating tumorigenic cells were found in breast cancer. In colon cancer, the proliferative activity of the tumorigenic population has not been defined, although it represents an essential parameter for the development of more effective therapeutic strategies. Here, we show that tumorigenic colon cancer cells can be found in a rapidly proliferating state in vitro and in vivo, both in human tumors and mouse xenografts. Inhibitors of polo-like kinase1 (Plk1), a mitotic kinase essential fo…
"Table 24" of "Measurement of event shape and inclusive distributions at s**(1/2) = 130-GeV and 136-GeV."
1997
3-jet rate for the Jade Algorithm.
"Table 23" of "Measurement of event shape and inclusive distributions at s**(1/2) = 130-GeV and 136-GeV."
1997
2-jet rate for the Jade Algorithm.
"Table 25" of "Measurement of event shape and inclusive distributions at s**(1/2) = 130-GeV and 136-GeV."
1997
4-jet rate for the Jade Algorithm.
"Table 26" of "Measurement of event shape and inclusive distributions at s**(1/2) = 130-GeV and 136-GeV."
1997
5-jet rate for the Jade Algorithm.
"Table 14" of "Measurement of event shape and inclusive distributions at s**(1/2) = 130-GeV and 136-GeV."
1997
Oblateness distribution. Axis definition is from corrected charged plus neutral particles.
"Table 134" of "Studies of QCD at e+ e- centre-of-mass energies between 91-GeV and 209-GeV."
2004
Oblateness distribution at c.m. energy 133.00 GeV.
"Table 25" of "Energy dependence of event shapes and of alpha(s) at LEP-2."
1999
Distributions of Aplanarity at cm energies 133, 161 and 172 GeV.