Search results for "133"
showing 10 items of 144 documents
Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4
2007
A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells within a tumor. Here, we describe the identification and characterization of such cells from colon carcinomas using the stem cell marker CD133 that accounts around 2% of the cells in human colon cancer. The CD133(+) cells grow in vitro as undifferentiated tumor spheroids, and they are both necessary and sufficient to initiate tumor growth in immunodeficient mice. Xenografts resemble the original human tumor maintaining the rare subpopulation of tumorigenic CD133(+) cells. Further analysis revealed that the CD133(+) cells produce and utilize IL-4 to protect themselves from apoptosis. Consistently, trea…
Cannabinoid CB1 receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle.
2007
The purpose of the present study was to examine whether cannabinoid receptor agonists influence spontaneous contractile activity of longitudinal muscle in mouse ileum in vitro. Isolated segments of mouse ileum displayed spontaneous contractions with an amplitude and frequency of about 300 mg and 30 cpm, respectively. The endocannabinoid anandamide (1-100 microM), the selective cannabinoid CB(1) receptor agonist, ACEA (0.1 microM-10 microM), but not the selective cannabinoid CB(2) receptor agonist, JWH 133 (0.1 microM-10 microM), reduced in a concentration-dependent manner the spontaneous mechanical activity. The inhibitory effect consisted in a decrease of the mean amplitude of longitudinal…
CD133 Expression Is Not Synonymous to Immunoreactivity for AC133 and Fluctuates throughout the Cell Cycle in Glioma Stem-Like Cells.
2015
A transmembrane protein CD133 has been implicated as a marker of stem-like glioma cells and predictor for therapeutic response in malignant brain tumours. CD133 expression is commonly evaluated by using antibodies specific for the AC133 epitope located in one of the extracellular domains of membrane-bound CD133. There is conflicting evidence regarding the significance of the AC133 epitope as a marker for identifying stem-like glioma cells and predicting the degree of malignancy in glioma cells. The reasons for discrepant results between different studies addressing the role of CD133/AC133 in gliomas are unclear. A possible source for controversies about CD133/AC133 is the widespread assumpt…
La privatizzazione dell'Università. Il modello delle fondazioni. Un caso di perniciosa penetrazione del diritto privato nel diritto pubblico
2014
Lo studio prende mosse dalla ricostruzione dell'ordinamento universitario, per poi concentrarsi sul tema delle fondazioni universitarie. Dando conto tanto di quelle istituite in forza della legge 388/2000 (e del d.P.R. 254/2001), quanto di quelle di cui al decreto-legge 112/2008 convertito in legge 133/2008 (c.d. riforma Gelmini), l'Autore ne pone in luce aspetti positivi e dubbi di incostituzionalità, giungendo a proporre nuove forme di partenariato pubblico-privato.
Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonicDrosophilabrain
2016
The specification of distinct neural cell types in central nervous system development crucially depends on positional cues conferred to neural stem cells in the neuroectoderm. Here, we investigate the regulation and function of the epidermal growth factor receptor (EGFR) signalling pathway in early development of theDrosophilabrain. We find that localized EGFR signalling in the brain neuroectoderm relies on a neuromere-specific deployment of activating (Spitz, Vein) and inhibiting (Argos) ligands. Activated EGFR controls the spatially restricted expression of all dorsoventral (DV) patterning genes in a gene- and neuromere-specific manner. Further, we reveal a novel role of DV genes—ventral …
Cancer Stem Cells: to be or not to be, is that the problem?
2014
The HDAC6 Inhibitor tubacin induces release of CD133+ extracellular vesicles from cancer cells
2017
Tumor-derived extracellular vesicles (EVs) are emerging as an important mode of intercellular communication, capable of transferring biologically active molecules that facilitate the malignant growth and metastatic process. CD133 (Prominin-1), a stem cell marker implicated in tumor initiation, differentiation and resistance to anti-cancer therapy, is reportedly associated with EVs in various types of cancer. However, little is known about the factors that regulate the release of these CD133+ EVs. Here, we report that the HDAC6 inhibitor tubacin promoted the extracellular release of CD133+ EVs from human FEMX-I metastatic melanoma and Caco-2 colorectal carcinoma cells, with a concomitant dow…
El Rey Don Pedro de Castilla, el Justiciero
Caplletra ornada. Sign.: A-E4. Text amb postil·les marginals. Reclams.
Aristóteles entre doxografía y biografía: sobre Diógenes Laercio V 31
2019
Se pretende llamar la atención sobre un par de frases que aparecen justo hacia la mitad de la controvertida doxografía de Aristóteles que se puede leer en las Vidas y doctrinas de los filósofos más ilustres de Diógenes Laercio V 31, y que desde luego no corresponden a ningún sistema doxográfico conocido. Como sucede no pocas veces en la obra laerciana, la misma apreciación sobre si el filósofo debe o no enamorarse y contraer matrimonio se repite idéntica en otras doxografías completamente distintas: la cirenaica (DL II 91), la estoica (DL VII 129) y la epicúrea (DL X 118). Cabe plantearse, pues, el origen de este interés, en varias doxografías, por la vida sentimental, podríamos decir, de l…