Search results for "140"

Collaboration experience in the supply chain of knowledge and patent development

2017

In this paper, we aim at understanding the role of collaboration experience in supply chains of knowledge (SCoK). The SCoK of a company is its supply chain not related to the flow of physical goods but to the flow of R&D commodities. R&D commodities are for example patents, technologies, research services, studies, and projects, and, in high-tech industries, their development and commercialisation are considered as important as real products. To accomplish our aim in this paper, we fulfil the following research objectives: (1) investigate the relationship between the collaboration experience in SCoK and the propensity of the firm to develop new patents; (2) examine how the structural embedd…

Digital health technology enhances resilient behaviour: evidence from the ward

2019

PurposeIn the healthcare management domain, there is a lack of knowledge concerning the role of resilience practices in improving patient safety. The purpose of this paper is to understand the capabilities that enable healthcare resilience and how digital technologies can support these capabilities.Design/methodology/approachWithin- and cross-case research methodology was used to study resilience mechanisms and capabilities in healthcare and to understand how digital health technologies impact healthcare resilience. The authors analyze data from two Italian hospitals through the lens of the operational failure literature and anchor the findings to the theory of dynamic capabilities.Findings…

The effect of language use on the financial performance of microfinance banks: Evidence from cross-border activities in 74 countries

2019

Abstract This multi-year study examines the relationship between financial performance and language use, observing 405 partnerships between microfinance banks and their international financial partners in 74 countries. Drawing on language research in international business, we find that microfinance banks based in English-speaking, French-speaking, and Spanish-speaking countries have higher performance. Furthermore, the linguistic distance between the home country of a microfinance bank and the home country of its international partner(s) is negatively related to its financial performance. Our large-scale study confirms the effect of language use on organization-level financial performance …

La participación de las mujeres intérpretes en las orquestas sinfónicas de la Comunidad Valenciana: una realidad hermética

2018

Calcium Carbonate and Phosphate Reference Materials for Monitoring Bulk and Microanalytical Determination of Sr Isotopes

2017

In situ laser ablation analyses rely on the microanalytical homogeneity of reference materials (RMs) and a similar matrix and mass fraction between unknown samples and RMs to obtain reliable results. Suitable carbonate and phosphate RMs for determination of Sr isotope ratios in such materials are limited. Thus, we determined Sr-87/Sr-86 ratios of several carbonate (JCt-1, JCp-1, MACS-1, MACS-3) and phosphate (MAPS-4, MAPS-5, NIST SRM 1400, NIST SRM 1486) international RMs using dissolved samples and two different multi-collector inductively coupled plasma-mass spectrometers (MC-ICP-MS). Our Sr isotope data are in agreement with published data and have an improved measurement precision for s…

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

2019

Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural ne…

Hospital readmission rates: signal of failure or success?

2013

AbstractHospital readmission rates are increasingly used as signals of hospital performance and a basis for hospital reimbursement. However, their interpretation may be complicated by differential patient survival rates. If patient characteristics are not perfectly observable and hospitals differ in their mortality rates, then hospitals with low mortality rates are likely to have a larger share of un-observably sicker patients at risk of a readmission. Their performance on readmissions will then be underestimated. We examine hospitals’ performance relaxing the assumption of independence between mortality and readmissions implicitly adopted in many empirical applications. We use data from th…

Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140—A Multitarget Compound for Alzheimer’s Disease

2019

ARN14140 is a galantamine-memantine conjugate that acts upon both cholinergic and glutamatergic pathways for better management of Alzheimer's disease. Poor oral bioavailability and pharmacokinetics meant that earlier preclinical in vivo studies employed intracerebroventricular injection to administer ARN14140 directly to the brain. The aim of the present study was to evaluate the feasibility of using constant current transdermal iontophoresis for the noninvasive systemic delivery of ARN14140 and to quantify the amounts present in the blood and the brain. Preliminary experiments in vitro were performed using porcine skin and validated with human skin. Cumulative ARN14140 permeation across th…

Promouvoir un management environnemental participatif

2011

Page 80-89; International audience; L'expérience nous montre que, faute de solliciter l'engagement des parties prenantes, il risque d'y avoir un écart important entre le discours des dirigeants et les pratiques réelles des entreprises en matière de management environnemental (ou gestion environnementale). Par ailleurs, les dirigeants doivent de plus en plus tenir compte des attentes de diverses parties prenantes en cette matière. Les clients, les employés, les fournisseurs et les communautés locales ne veulent plus seulement être informés; ils tiennent aussi à participer à la prise de décisions environnementales étant donné qu'ils en subissent les conséquences. Dans ce contexte, la question…

High frequency modeling technique for three phase power electronics module

2015

Nowadays, the high integrated power electronics modules (PMs), characterized by high speed, low loss and hard ware miniaturization, represent a new technology that meets the emerging demands of many applications, such us vehicle and home appliance, renewable energy sources in smart grid. The integration process and the high switching speeds increase the PM electromagnetic emissions that can create electromagnetic interference (EMI) with electric/electronic devices near the PMs. For this reason, electromagnetic compatibility (EMC) have to be carefully considered, yet in the design phase, to guarantee the reliability of PM systems. In this paper a method to develop a high frequency (HF) model…