Search results for "14"
showing 10 items of 9841 documents
Role of acetaldehyde in alcohol addiction: current evidence and future perspectives
2011
The effects of alcohol have been widely studied during the past century, corroborating the idea that this tiny chemical compound acts throughout most of our neurotransmitter systems since it is capable of inducing addictive behaviour. Two of the most serious problems of alcohol addiction are craving and relapse; several studies have demonstrated that relapse is related to the anxious state which occurs during withdrawal, and it has been proved that this behavioural modifications results from an alteration of the dopaminergic and serotonergic systems. An important role in the neurobiology of alcohol addiction is played by acetaldehyde (ACD), ethanol first metabolite. Our recent studies indee…
Modulation of alcohol consumption using an operant self-administration paradigm: effects of a new dopamine aminoacidic conjugate, Phenylalanine-β(3,4…
2014
Rewarding and reinforcing properties of alcohol have been shown to be mediated by activation of the mesolimbic dopaminergic system. Experimental evidences suggest that mesolimbic dopamine system is hypofunctional in addicted brain; further, reduced dopaminergic activity outlasts somatic signs of withdrawal and may drive craving and relapse. Boosting strategy on dopaminergic neurons could represent a valid therapy. Effects of pharmacological manipulation of brain Dopaminergic receptors by a new dopamine conjugate, Phenylalanine-β(3,4dihydroxyphenyl)-etilamide (DA-Phen), on operant behaviour and on both acute and prolonged withdrawal symptoms during ethanol abstinence have been evaluated. Mal…
Embodied and affective negotiation over spatial and epistemic group territories among school-children : (Re)producing moral orders in open learning e…
2022
This study investigates how schoolchildren organise their spatial and epistemic ‘territories’ among peer groups to constitute local social and moral orders in open learning environments. Open learning environments, the result of recent school reforms in Finland, challenge the conventional organisation of traditional classrooms. We use a microanalysis of naturally occurring video-recorded interactions to show the interactional dynamics of how children produce epistemic and spatial territories by creating moment-by-moment unfolding participation frameworks and emotional alliances. We suggest that the lack of institutional structures in open learning environments withholds children from the te…
The role of health literacy in the association between academic performance and substance use.
2022
Abstract Background To address social inequalities in adolescent substance use and consequent disparities in health, it is important to identify the mechanisms of the association between substance use and academic performance. We study the role of health literacy (HL) in the association between academic performance and weekly smoking, monthly alcohol use and cannabis ever-use among adolescents in Europe. Methods SILNE-R school survey data, which was collected in 2016–17 with paper-and-pencil-method from Hanover (GE), Amersfoort (NL) and Tampere (FI), were used (N = 5088, age 13–19). Health Literacy for School-aged Children instrument was used to assess students’ HL. Logistic regression anal…
The Associations Between Leisure-Time Physical Activity and Academic Performance: A Twin Study
2021
Background: Both genetic and environmental influences have been shown to contribute to the association between physical activity and overall academic performance. The authors examined whether leisure-time physical activity (LTPA) shares genetic and environmental variances between spelling, essay writing, reading aloud, reading comprehension, and mathematics in early adolescence. Moreover, they investigated whether genetic polymorphisms associated with physical activity behavior affect these academic skills. Methods: Participants were 12-year-old Finnish twins (n = 4356–4370 twins/academic skill, 49% girls). Academic skills were assessed by teachers, and LTPA was self-reported. Polygenic sco…
Educational and family-related determinants of organized sports participation patterns from adolescence to emerging adulthood : A four-year follow-up…
2022
This study aimed to identify organized sports participation patterns and their prevalence from adolescence to emerging adulthood, and the educational and family-related determinants of the patterns. Adolescents in the Finnish Health Promoting Sports Club (FHPSC) study answered a health behaviour questionnaire and reported on sports club participation at ages 15 and 19 (N = 609). In emerging adulthood, dropouts (total 41.05%; females 43.72%; males 36.56%), maintainers (30.87; 26.44; 38.33), nonparticipants (27.59; 29.32; 24.67), and joiners (0.49; 0.52; 0.44) (p =.024) were identified. A mixed multinomial logistic regression analysis showed, that male gender, as compared to female gender, in…
School achievement in adolescence and the risk of mental disorders in early adulthood: a Finnish nationwide register study
2023
AbstractSchool grades in adolescence have been linked to later psychiatric outcomes, but large-scale nationwide studies across the spectrum of mental disorders are scarce. In the present study, we examined the risk of a wide array of mental disorders in adulthood, as well as the risk of comorbidity, associated with school achievement in adolescence. We used population-based cohort data comprising all individuals born in Finland over the period 1980–2000 (N = 1,070,880) who were followed from age 15 or 16 until a diagnosis of mental disorder, emigration, death, or December 2017, whichever came first. Final grade average from comprehensive school was the exposure, and the first diagnosed ment…
Encoding specificity instead of online integration of real-world spatial regularities for objects in working memory
2022
Most objects show high degrees of spatial regularity (e.g. beach umbrellas appear above, not under, beach chairs). The spatial regularities of real-world objects benefit visual working memory (VWM), but the mechanisms behind this spatial regularity effect remain unclear. The "encoding specificity" hypothesis suggests that spatial regularity will enhance the visual encoding process but will not facilitate the integration of information online during VWM maintenance. The "perception-alike" hypothesis suggests that spatial regularity will function in both visual encoding and online integration during VWM maintenance. We investigated whether VWM integrates sequentially presented real-world obje…
Luokanopettajien näkemyksiä toiminnallisista oppimisympäristöistä
2016
Tämän tutkimuksen tarkoituksena oli selvittää luokanopettajien näkemyksiä ja käsityksiä siitä, mitkä tekijät luokanopettajan työssä tukevat ja mitkä estävät toiminnallisten opetusmenetelmien käyttöä eri oppimisympäristöissä. Toiminnalliseen opetukseen liittyviä tekijöitä selvitettiin tutkimuksessa fyysisen, sosiaalisen sekä pedagogisen oppimisympäristö -käsitteiden avulla. Tutkimuksen aineisto kerättiin laadullisella kyselylomakkeella vuodenvaihteessa 2015–2016. Tutkimukseen osallistui 31 luokanopettajaa eri puolelta Suomea. Aineiston analyysimenetelmänä toimi teoriaohjaava sisällönanalyysi. Analysoinnin pohjalta muodostui kolme toiminnalliseen opetukseen liittyvää pääkategoriaa: kouluraken…
Copper Induces a Core Plasmon in Intermetallic Au(144,145)–xCux(SR)60 Nanoclusters
2015
The electronic structure and optical absorption spectra of intermetallic thiol-stabilized gold-copper clusters, having 144-145 metal atoms and 60 thiols, were studied by ab initio computations. The widely known icosahedral-based cluster model from the work of Lopez-Acevedo et al. (2009) was used, and clusters doped with one to 30 copper atoms were considered. When doped inside the metal core, copper induces dramatic changes in the optical spectrum as compared to the previously studied all-gold Au144(SR)60. An intense broad absorption peak develops in the range 535-587 nm depending on the amount of doping and doping sites. This result agrees very well with recent experiments by the Dass grou…