Search results for "15"
showing 10 items of 8669 documents
Effects of overnight military training and acute battle stress on the cognitive performance of soldiers in simulated urban combat
2022
Understanding the effect of stress, fatigue, and sleep deprivation on the ability to maintain an alert and attentive state in an ecologically valid setting is of importance as lapsing attention can, in many safety-critical professions, have devastating consequences. Here we studied the effect of close-quarters battle (CQ battle) exercise combined with overnight military training with sleep deprivation on cognitive performance, namely sustained attention and response inhibition. In addition, the effect of the CQ battle and overnight training on cardiac activity [heart rate and root mean square of the successive differences (RMSSD)] during the cognitive testing and the relationship between ca…
Superficial venous thrombosis: role of inherited deficiency of natural anticoagulants in extension to deep veins
2009
AIM: Superficial venous thrombosis (SVT) has been considered for a long time a limited clinical condition of low importance, but this approach has changed in recent years, when several studies demonstrated that extension to deep veins occurs in 7.3 to 44% of patients, with high prevalence of pulmonary embolism. The aim of this study was to evaluate the prevalence of inherited deficiency of natural coagulation inhibitors in patients suffering from SVT in both normal and varicose veins, and to understand their role in extension to deep veins. METHODS: The study included 83 patients with SVT, without clinically obvious risk factors. Ultrasound examination was performed, and deficiencies of Pro…
Contratos de permuta financiera ante el impuesto sobre el valor añadido
2021
El estudio de la tributación en el impuesto sobre el valor añadido de los contratos de permuta financiera, exige el previo conocimiento de estos derivados financieros. Para ello acudimos a la jurisprudencia del Tribunal de Justicia de la Unión europea y a las nociones de la Contabilidad internacional
Behavioral Inhibition Underlies the Link Between Interoceptive Sensitivity and Anxiety-Related Temperamental Traits
2017
Interoceptive sensitivity is a biologically determined, constitutional trait of an individual. High interoceptive sensitivity has been often associated with proneness to anxiety. This association has been explained by elevated autonomic responsiveness in anxious individuals. However, in a heartbeat discrimination task (discrimination of heartbeats’ simultaneity to an external stimulus) low cardiac responsiveness has accompanied enhanced performance. The relation between these factors seems task dependent, and cannot comprehensively explain the link between interoceptive sensitivity and anxiety. We explored for additional explanatory factors for this link. More specifically, we studied which…
Associations Between Sympathetic Nervous System Synchrony, Movement Synchrony, and Speech in Couple Therapy
2022
Background: Research on interpersonal synchrony has mostly focused on a single modality, and hence little is known about the connections between different types of social attunement. In this study, the relationship between sympathetic nervous system synchrony, movement synchrony, and the amount of speech were studied in couple therapy. Methods: Data comprised 12 couple therapy cases (24 clients and 10 therapists working in pairs as co-therapists). Synchrony in electrodermal activity, head and body movement, and the amount of speech and simultaneous speech during the sessions were analyzed in 12 sessions at the start of couple therapy (all 72 dyads) and eight sessions at the end of therapy (…
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
A new approach for estimating a nonlinear growth component in multilevel modeling
2011
This study presents a new approach to estimation of a nonlinear growth curve component with fixed and random effects in multilevel modeling. This approach can be used to estimate change in longitudinal data, such as day-of-the-week fluctuation. The motivation of the new approach is to avoid spurious estimates in a random coefficient regression model due to the synchronized periodical effect (e.g., day-of-the-week fluctuation) appearing both in independent and dependent variables. First, the new approach is introduced. Second, a Monte Carlo simulation study is carried out to examine the functioning of the proposed new approach in the case of small sample sizes. Third, the use of the approac…
Depressive symptoms during adolescence: Do learning difficulties matter?
2011
To examine whether learning difficulties play a role in depressive symptoms, 658 Finnish adolescents were asked to complete scales for depression three times during the transition to post-comprehensive education. They also reported on their learning difficulties and feelings of inadequacy as a student. The results showed that learning difficulties prospectively predicted depressive symptoms. Moreover, the impact of learning difficulties was mediated via inadequacy as a student: learning difficulties predicted feelings of inadequacy as a student which, in turn, contributed to greater increases in depressive symptoms. Finally, gender moderated the association between learning difficulties an…
Simultaneous optimization of harvest schedule and measurement strategy
2013
In many recent studies, the value of forest inventory information in the harvest scheduling has been examined. Usually only the profitability of measuring simultaneously all the stands in the area is examined. Yet, it may be more profitable to concentrate the measurement efforts to some subset of them. In this paper, the authors demonstrate that stochastic optimization can be used for defining the optimal measurement strategy simultaneously with the harvest decisions. The results show that without end-inventory constraints, it was most profitable to measure the stands that were just below the medium age. Measuring the oldest stands was not profitable at all. It turned out to be profitable t…
Shared and personal learning spaces: Challenges for pedagogical design
2012
Abstract The development of new tools for collaboration, such as social software, plays a crucial role in leisure time and work activities. The aim of this article is to summarize the research in the field of computer-supported collaborative learning (CSCL). This is done particularly from the perspective of the blurred line between individual (personal) and group-level (shared) learning that the use of the new tools has forced us to re-think. First, individual and group-level perspectives to learning are discussed to make sense of the major notions of how learning is understood in CSCL research. Second, based on this theoretical grounding, it will be further elaborated what this means to th…