Search results for "1713"

showing 10 items of 38 documents

Binary evolution of PSR J1713+0747

2007

PSR J1713+0747 is a binary millisecond radio pulsar with a long orbital period (Porb ∼ 68 d) and a very low neutron star mass (M NS = 1.3 ± 0.2 M⊙). We simulate the evolution of this binary system with an accurate numerical code, which keeps into account both the evolution of the primary and of the whole binary system. We show that strong ejection of matter from the system is fundamental to obtain a mass at the end of the evolution that is within 1 - σ from the observed one, but propeller effects are almost negligible in such a system, where the accretion rate is always near to the Eddington limit. We show that there are indeed two mechanisms can account for the amount of mass loss from the…

PhysicsPulsars: individual: PSR J1713+0747close; Pulsars: individual: PSR J1713+0747; Relativity; Stars: neutron; X-rays: binaries [Accretion accretion discs; Binaries]X-ray binaryAstrophysicsBinary pulsarStars: neutronRelativityNeutron starsymbols.namesakeX-rays: binariesPulsarMillisecond pulsarBinaries: closeStellar mass lossEddington luminositysymbolsBinary systemAccretion accretion disc
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Relacion que haze una aldeana a otra amiga de su Aldèa, dandole cuenta de como la ... Ciudad de Valencia manifestò su grande zelo, y amor, en la feli…

Sign.: [ ]2 Text a dues col Reclams

Ferran VI rei d'Espanya 1713-1759 Poesia Obres anteriors al 1800Festivals Comunitat Valenciana 1746 Obres anteriors al 1800
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Don Francisco Antonio de Salcedo y Aguirre, Marquès del Vadillo ... Intendente General de lo Político, y Militar del Exercito, y Plazas de esta Andal…

Com a tít. el començament del text Sign.: [ ]2 Cristus a la part superior de la 1ª pàg

Forces armades Andalusia 1713I Obres anteriors al 1800
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Noticia de las elevadas y no vistas demonstraciones que ha practicado la ... ciudad de Valencia en la proclamacion del regio monarca Don Fernando VI,…

Precedeix al títol: [creu de Malta Dades del peu d'impremta preses del colofó Data deduïda del text Sign.: [ ]2 Text a dues col. - Reclams Darrere del tít., 3 grav. xil. un d'ells, el esc. de Ferran VI

Poesia castellana S. XVIII Fonts Obres anteriors al 1800. lemacFerran VI rei d'Espanya 1713-1759 Obres anteriors al 1800. lemacLiteratura de canya i cordill castellana S. XVIII Fonts Obres anteriors al 1800 lemac
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Protein misfolding, amyotrophic lateral sclerosis and guanabenz: Protocol for a phase II RCT with futility design (ProMISe trial)

2017

IntroductionRecent studies suggest that endoplasmic reticulum stress may play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through an altered regulation of the proteostasis, the cellular pathway-balancing protein synthesis and degradation. A key mechanism is thought to be the dephosphorylation of eIF2α, a factor involved in the initiation of protein translation. Guanabenz is an alpha-2-adrenergic receptor agonist safely used in past to treat mild hypertension and is now an orphan drug. A pharmacological action recently discovered is its ability to modulate the synthesis of proteins by the activation of translational factors preventing misfolded protein accumula…

0301 basic medicineOncologyPathologyamyotrophic lateral sclerosisamyotrophic lateral sclerosis; motor neurone disease; neuromuscular disease; randomized clinical trial guanabenz; unfolded protein response; adrenergic alpha-2 receptor agonist s; age of onset; amyotrophic lateral sclerosis; disease progression; double-blind method; endoplasmic reticulum stress; guanabenz; humans; italy; medical futility; neuroprotective agents; proteostasis deficienciesamyotrophic lateral sclerosis; motor neurone disease; neuromuscular disease; randomized clinical trial guanabenz; unfolded protein response; Medicine (all)randomized clinical trial guanabenzHelsinki declaration0302 clinical medicineProtocolAdrenergic alpha-2 Receptor Agonists1506Amyotrophic lateral sclerosisAge of OnsetGuanabenzMedicine (all)amyotrophic lateral sclerosis; motor neurone disease; neuromuscular disease; randomized clinical trial guanabenz; unfolded protein responseNeurodegenerationamyotrophic lateral sclerosis; motor neurone disease; neuromuscular disease; randomized clinical trial guanabenz; unfolded protein response;amyotrophic lateral sclerosis; guanabenz; motor neurone disease; neuromuscular disease; randomized clinical trial; unfolded protein response; Adrenergic alpha-2 Receptor Agonists; Age of Onset; Amyotrophic Lateral Sclerosis; Disease Progression; Double-Blind Method; Endoplasmic Reticulum Stress; Guanabenz; Humans; Italy; Medical Futility; Neuroprotective Agents; Proteostasis DeficienciesGeneral Medicineunfolded protein responseEndoplasmic Reticulum StressRiluzoleNeuroprotective AgentsNeurologyTolerabilityItalyDisease Progression1713GuanabenzMedical Futilitymedicine.drugmedicine.medical_specialtyamyotrophic lateral sclerosis; motor neurone disease; neuromuscular disease; randomized clinical trial guanabenz; unfolded protein response; Adrenergic alpha-2 Receptor Agonists; Age of Onset; Amyotrophic Lateral Sclerosis; Disease Progression; Double-Blind Method; Endoplasmic Reticulum Stress; Guanabenz; Humans; Italy; Medical Futility; Neuroprotective Agents; Proteostasis Deficiencies; Medicine (all)Neuroprotection03 medical and health sciencesmotor neurone diseaseDouble-Blind MethodInternal medicinemedicineHumansProteostasis Deficienciesbusiness.industryAmbientaleneuromuscular diseaserandomized clinical trialmedicine.diseaseClinical trial030104 developmental biologybusiness030217 neurology & neurosurgery
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Don Francisco Antonio de Salcedo y Aguirre, Marques del Vadillo ... Intendente de lo Politico, y militar del Exercito, y Plaza de Zeuta, y las demàs …

1713

Com a tít. el començament del text Sign.: ¶4 Reclams Cristus a la part superior de la 1ª pàg

Impostos Andalusia 1713 Obres anteriors a 1800Impostos Andalusia 1713 Obres anteriors al 1800
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Poétique de l’utilité. Fictions évaluatrices et expérimentations sexuelles chez Diderot

2016

International audience; L’objet de cet article est de montrer que l'appréhension à partir de la poétique des lois concernant la vie elle-même et sa production est à prendre au sérieux. Dans la perspective ouverte par Bordeu, les hybrides vivants imaginés ne sont pas tant des conjectures et encore moins un programme d’action, que les résultats d’un exercice réglé de la pensée, étalonné selon une règle poétique, dont l’enjeu est politique : il s’agit d’évaluer des lois positives. Cette hypothèse de lecture permet de relire d’autres textes de Diderot, d’identifier peut-être certaines sources de cette pratique philosophique et, d’un point de vue général, d’appuyer l’interprétation du discours p…

[SHS.PHIL] Humanities and Social Sciences/PhilosophyExpérience de penséePhilosophie moraleSupplément au Voyage de Bougainville[SHS.PHIL]Humanities and Social Sciences/PhilosophyLittérature et philosophieLumières françaisesLe rêve de d'AlembertDiderot Denis 1713-1784
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Damnatio quamplurium propositionum excerptarum ex libro Gallico Idiomate impresso, & in plures Tomos distributo, sub titulo: Le nouveau Testament en …

1713

Escut papal xil. a la port. Caplletra ornada Sign.: A6 Text a línia tirada i a dues col. Reclams

Polèmiques teològiques Obres anteriors a 1800Documents pontificis 1713 Obres anteriors a 1800Quesnel Pasquier (1634-1719) Crítica i interpretació Obres anteriors a 1800
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Continuando el Rey ... su deseo à quanto pueda facilitàr en alivio de sus Vassallos, ha resuelto, que no obstante, que el termino señalado a los P…

1713

Cristus a la part superior del full

Impostos Andalusia 1713 Obres anteriors a 1800
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Relacion breve de las admirables fiestas y respetables obsequios con que la noble t real corte de Madrid ha expresado en la pùblica y cèlebre entrada…

Precedeix al tít.: ✠ Filets Text a 2 col. - Reclams Sign.: [ ]2

Ferran VI rei d'Espanya 1713-1759 Poesia Obres anteriors al 1800Festivals Madrid (Comunitat Autònoma) 1746 Obres anteriors al 1800Poesia castellana S. XVIII Fonts Obres anteriors al 1800
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