Search results for "182"
showing 10 items of 1012 documents
Economic Value Added – A General Review of the Concept
2017
Business organizations of the 21st century, a century driven by globalization,internationalization and speed, must compete on changing and evolving markets. One of the maingoals of every business is to create value for its shareholders, value that is generated by the properusage of existing resources. The notion that can be utilized to successfully illustrate the increase ineconomic value is the economic value added concept.. The Economic Value Added concept knownalso as EVA is an add on to value, value based management and economic value.. EVA is a methodand a tool for quantification and measurement of the value created by a business organization.
Discovery of varlaxins, new aeruginosin-type inhibitors of human trypsins
2022
Low-molecular weight natural products display vast structural diversity and have played a key role in the development of novel therapeutics. Here we report the discovery of novel members of the aeruginosin family of natural products, which we named varlaxins. The chemical structures of varlaxins 1046A and 1022A were determined using a combination of mass spectrometry, analysis of one- and two-dimensional NMR spectra, and HPLC analysis of Marfey's derivatives. These analyses revealed that varlaxins 1046A and 1022A are composed of the following moieties: 2-O-methylglyceric acid 3-O-sulfate, isoleucine, 2-carboxy-6-hydroxyoctahydroindole (Choi), and a terminal arginine derivative. Varlaxins 10…
Hydrophobic pocket targeting probes for enteroviruses
2015
Visualization and tracking of viruses without compromising their functionality is crucial in order to understand virus targeting to cells and tissues, and to understand the subsequent subcellular steps leading to virus uncoating and replication. Enteroviruses are important human pathogens causing a vast number of acute infections, and are also suggested to contribute to the development of chronic diseases like type I diabetes. Here, we demonstrate a novel method to target site-specifically the hydrophobic pocket of enteroviruses. A probe, a derivative of Pleconaril, was developed and conjugated to various labels that enabled the visualization of enteroviruses under light and electron micros…
Site-specific targeting of enterovirus capsid by functionalized monodisperse gold nanoclusters
2014
Development of precise protocols for accurate site-specific conjugation of monodisperse inorganic nanoparticles to biological material is one of the challenges in contemporary bionanoscience and nanomedicine. We report here a successful site-specific covalent conjugation of functionalized atomically monodisperse gold clusters with 1.5-nm metal cores to viral surfaces. Water-soluble Au102(para-mercaptobenzoic acid)44 clusters, functionalized by maleimide linkers to target cysteines of viral capsid proteins, were synthesized and conjugated to enteroviruses echovirus 1 and coxsackievirus B3. Quantitative analysis of transmission electron microscopy images and the known virus structures showed …
Challenges of nation-branding for stimulation of Latvian exports
2017
Abstract The presented research aims to contribute to the conceptualisation of the nation-brand of Latvia with the purpose of stimulation of national export performance. The subject of the research is three aspects presumably challenging the branding of Latvia with reference to national export development. The investigated challenges are the barriers and opportunities for green-branding of Latvia; the absence of the generally accepted indication of the geographical identity of the Baltic region; and the contradictable popular image of Latvia as a cheap country. The research poses two research questions inquiring into the issues of nation-branding of Latvia currently being faced in the conte…
The background music-content congruence of TV advertisements: A neurophysiological study
2021
Abstract Music affects viewers’ responses to advertisements. In this study we present the findings of an experiment that investigates the emotional and cognitive reactions of subjects’ brains during exposure to television advertisements with music congruent, and incongruent, with the advertisement content. We analyze the electroencephalography signals and eye-tracking behaviors of a group of 90 women watching six TV advertisements. The study's findings suggested that incongruent music generates higher levels of attention and advertisement recall. On the other hand, frontal asymmetry measured through electroencephalography was shown to be higher with congruent music. Similarly, cognitive wor…
Searching for new paradigms in a globalized world: Business ethics as a management strategy
2008
The process of globalization is an undeniable reality of today's world. Yet, paradoxically, the cornerstone of this phenomenon, economic performance, varies widely across the world whatever indicator (for example, GDP/habitant, competitiveness) we choose to use to compare countries. Increasingly, studies tend to explain this apparently paradoxical situation with reference to the issue of corruption and ethics. In essence, corruption is perceived to be an important impediment to the economic development of a country (or area). Many studies of corruption are focused at the national level. The aim of this conceptual paper is to explore the role of the firm (as opposed to national states or int…
An upper echelons perspective on information technology business value
2017
This paper argues that information technology (IT) outcomes are more valuable to companies when their top management team (TMT) moves from flirting with IT to marriage. Previous research has demonstrated an association between top management support (TMS) and IT value. We extend the concept of TMS with the imbrication metaphor to define the construct of TMT-IT imbrication, which allows us to account for a tighter and continuous entwining of the TMT and IT to create IT value. Our definition of the TMT-IT imbrication construct embraces four dimensions: involvement, participation, attention, and use. In addition, with the support of upper echelons (UE) theory, we explore certain managerial tra…
Los grupos de interés en las entidades de crédito Españolas
2012
RESUMENSe plantean los orígenes, evolución y clasificación de los grupos de interés (stakeholders). Se pone de relieve la relación que se entabla entre la entidad de crédito como organización social y sus diferentes grupos de interés, analizándose la importancia que se asigna a estos.El trabajo de campo se realizó a través de una encuesta contestada por 57 entidades de crédito españolas. Los resultados del estudio muestran la sensibilidad de las entidades de crédito hacia la RSE (Responsabilidad Social de la Empresa), con referencia al conjunto del sector financiero español. Nuestro objetivo es analizar la importancia que tienen los diversos grupos de interés: accionistas, empleados, client…
Análisis y resultados de un modelo de evaluación, apoyo y mejora de proyectos empresariales impulsados por jóvenes emprendedores1,2
2009
ResumenLas empresas de nueva creación juegan un papel crucial en la generación de empleo, el crecimiento económico, la innovación y la competitividad. Ello ha llevado a un número creciente de instituciones públicas a dedicar ingentes recursos al apoyo y fomento de iniciativas empresariales. Resulta por ello de especial interés analizar la eficacia de los distintos programas e identificar cuáles son las prácticas más efectivas. Este trabajo tiene como objetivo avanzar en la mejora de los sistemas de evaluación de programas de ayuda a emprendedores y mostrar cómo las mejoras introducidas pueden tener efectos sobre la calidad de los negocios creados. Para ello se analiza en profundidad el caso…