Search results for "1R"

CCDC 297366: Experimental Crystal Structure Determination

2006

Related Article: E.Schweizer, A.Hoffmann-Roder, J.A.Olsen, P.Seiler, U.Obst-Sander, B.Wagner, M.Kansy, D.W.Banner, F.Diederich|2006|Org.Biomol.Chem.|4|2364|doi:10.1039/b602585d

CCDC 704876: Experimental Crystal Structure Determination

2009

Related Article: L.Kiss, E.Forro, R.Sillanpaa, F.Fulop|2008|Tetrahedron:Asymm.|19|2856|doi:10.1016/j.tetasy.2008.11.035

Impact du système endocannabinoïdien sur la physiologie de l'obésité : effets de l'antagonisme des récepteurs CB1 sur le métabolisme glucido-lipidiqu…

2010

The endocannabinoïd system (ECS) is involved in many biological functions such as regulation of energy metabolism. Recently, several studies have shown an association between obesity and ECS overactivity. In addition, specific CB1R antagonists such as Rimonabant (SR141716) improved metabolic parameters in obese patients essentially through inactivation of central CB1R. However, peripheral CB1R inactivation could also contribute to the improvement of these parameters and it is this notion that we have studied. To this purpose, we tested the effects of SR141716 on obese mice in order to establish relationships between the ECS activity and lipid metabolism by looking more specifically to its r…

CCDC 139658: Experimental Crystal Structure Determination

2001

Related Article: P.Lahuerta, E.Moreno, A.Monge, G.Muller, J.Perez-Prieto, M.Sanau, S.-E.Stiriba|2000|Eur.J.Inorg.Chem.||2481|doi:10.1002/1099-0682(200012)2000:12<2481::AID-EJIC2481>3.0.CO;2-M

Chiroptical Phenomena in Reverse Micelles: The Case of (1R,2S)- Dodecyl (2-hydroxy-1-methyl-2-phenylethyl)dimethylammonium Bromide (DMEB)

2014

(1R,2S)-Dodecyl(2-hydroxy-1-methyl-2-phenylethyl)dimethylammonium bromide (DMEB) aggregates dispersed in carbon tetrachloride have been investigated by Fourier transform infrared (FT-IR), vibrational circular dichroism (VCD) and 1H nuclear magnetic resonance (NMR) spectroscopy at various surfactant concentration and water-to-surfactant molar ratio. Experimental data indicate that, even at the lowest investigated concentration and in absence of added water, DMEBmolecules associate in supramolecular assemblies. At higherDMEBconcentration the aggregates can confine watermolecules,making it plausible to think thatDMEB form reverse micelles and that watermolecules are quite uniformly distributed…

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-233 expressions: A study on postmenopausal mon…

2014

MiRNAs are fine-tuning modifiers of skeletal muscle regulation, but knowledge of their hormonal control is lacking. We used a co-twin case–control study design, that is, monozygotic postmenopausal twin pairs discordant for estrogen-based hormone replacement therapy (HRT) to explore estrogen-dependent skeletal muscle regulation via miRNAs. MiRNA profiles were determined from vastus lateralis muscle of nine healthy 54–62- years-old monozygotic female twin pairs discordant for HRT (median 7 years). MCF-7 cells, human myoblast cultures and mouse muscle experiments were used to confirm estrogen’s causal role on the expression of specific miRNAs, their target mRNAs and proteins and finally the ac…

Prenatal Exposure to Δ9-Tetrahydrocannabinol Affects Hippocampus-Related Cognitive Functions in the Adolescent Rat Offspring: Focus on Specific Marke…

2023

Previous evidence suggests that prenatal exposure to THC (pTHC) derails the neurodevelopmental trajectories towards a vulnerable phenotype for impaired emotional regulation and limbic memory. Here we aimed to investigate pTHC effect on hippocampus-related cognitive functions and markers of neuroplasticity in adolescent male offspring. Wistar rats were exposed to THC (2 mg/kg) from gestational day 5 to 20 and tested for spatial memory, object recognition memory and reversal learning in the reinforce-motivated Can test and in the aversion-driven Barnes maze test; locomotor activity and exploration, anxiety-like behaviour, and response to natural reward were assessed in the open field, elevate…

COVID-19 and diabetes management: What should be considered?

2020

Future perspectives of the pharmacological management of diabetic dyslipidemia

2019

Introduction: Diabetic dyslipidemia is frequent among patients with type 2 diabetes mellitus (T2DM) and is characterized by an increase in triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and small-dense (atherogenic) particles, and by a decrease in low high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (Apo) A1 that are strongly related to insulin resistance. The increased flux of free fatty acids from adipose tissue to the liver aggravates hepatic insulin resistance and promotes all of aspects of the dyslipidemic state. Areas covered: Statins are the first-line agents for treatment while other lipid-lowering drugs (ezetimibe, fibrate and proprotein convertase…

Maximum Dynamic Lower-Limb Strength Was Maintained During 24-Week Reduced Training Frequency in Previously Sedentary Older Women.

2018

Walker, S, Serrano, J, and Van Roie, E. Maximum dynamic lower-limb strength was maintained during 24-week reduced training frequency in previously sedentary older women. J Strength Cond Res 32(4): 1063-1071, 2018-There is little study into the effects of reducing strength training below the recommended twice weekly frequency, particularly in older women, despite the possibility that individuals will encounter periods of reduced training frequency. The purpose of the present study was to determine the effects of a period of reduced training frequency on maximum strength and muscle mass of the lower limbs in comparison with the recommended training frequency of twice per week. After an initia…