Search results for "2'"

showing 10 items of 1745 documents

The Vibrio choleare haemolysin anion channel is required for cell vacuolation and death

2002

SummarySeveral strains of Vibrio cholerae secrete ahaemolytic toxin of 63kDa, termed V. cholerae cytolysin (VCC). This toxin causes extensive vacuo-lation and death of cells in culture and forms ananion-selective channel in planar lipid bilayers and incells. Here, we identify inhibitors of the VCC anionchannel and show that the formation of the anionchannel is necessary for the development of the vacuoles and for the cell death induced by this toxin. Using markers of cell organelles, we show that vacuoles derive from different intracellular com-partments and we identify the contribution of lateendosomes and of the trans -Golgi network in vacuolebiogenesis.Introduction The Gram-negative bact…

4-Acetamido-4'-isothiocyanatostilbene-22'-disulfonic AcidImmunologyLipid BilayersVirulenceGolgi ApparatusVacuoleEndosomesBiology44'-Diisothiocyanostilbene-22'-Disulfonic AcidIn Vitro Techniquesmedicine.disease_causeTransfectionMicrobiologyModels BiologicalAmmonium ChlorideIon ChannelsMicrobiologyCell LineHemolysin ProteinsBacterial ProteinsVirologyOrganelleChlorocebus aethiopsmedicineAnimalsHumansSecretionVero CellsVibrio choleraeCell DeathCytotoxinsHemolysinAnti-Bacterial AgentsVibrio choleraeVacuolesCytolysinMacrolidesIntracellular
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CCDC 2009112: Experimental Crystal Structure Determination

2020

Related Article: Jonathan Bould, Kamil Lang, Kaplan Kirakci, Luis Cerdán, Daniel Roca-Sanjuán, Antonio Francés-Monerris, William Clegg, Paul G. Waddell, Marcel Fuciman, Tomáš Polívka, Michael G. S. Londesborough|2020|Inorg.Chem.|59|17058|doi:10.1021/acs.inorgchem.0c02277

5'6':67-conjuncto-(22'-dichloro-11'33'44'-hexamethyl-6'7':8'9':9'10'-tri-muH-nido-decaborane)-(77'88'10'-pentamethyl-56:89:910-tri-muH-nido-decaborane) 5'6':67-conjuncto-(22'-dichloro-11'33'44'-hexamethyl-6'7':8'9':9'10'-tri-muH-nido-decaborane)-(77'88'1010'-hexamethyl-56:89:910-tri-muH-nido-decaborane)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 634267: Experimental Crystal Structure Determination

2007

Related Article: S.Dobis, D.Schollmeyer, Chunmei Gao, Derong Cao, H.Meier|2007|Eur.J.Org.Chem.|2007|2964|doi:10.1002/ejoc.200700140

511-bis(((3-Methoxybenzyl)oxy)methyl)-561112-tetrahydro-512(1'2'):611(1''2'')dibenzenodibenzo(ae)cycloocteneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1994473: Experimental Crystal Structure Determination

2020

Related Article: Justin J. Dressler, Joshua E. Barker, Lucas J. Karas, Hannah E. Hashimoto, Ryohei Kishi, Lev N. Zakharov, Samantha N. MacMillan, Carlos J. Gomez-Garcia, Masayoshi Nakano, Judy I. Wu, Michael M. Haley|2020|J.Org.Chem.|85|10846|doi:10.1021/acs.joc.0c01387

614-bis(4-t-butyl-26-dimethylphenyl)-513-[1]benzothieno[2''3'':2'3']indeno[5'6':56]indeno[21-b][1]benzothiophene-551313-tetrone acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2077067: Experimental Crystal Structure Determination

2021

Related Article: Joshua E. Barker, Tavis W. Price, Lucas J. Karas, Ryohei Kishi, Samantha N. MacMillan, Lev N. Zakharov, Carlos J. G��mez���Garc��a, Judy I. Wu, Masayoshi Nakano, Michael M. Haley|2021|Angew.Chem.,Int.Ed.|60|22385|doi:10.1002/anie.202107855

614-bis(4-t-butyl-26-dimethylphenyl)[1]benzofuro[2''3'':2'3']indeno[5'6':56]indeno[21-b][1]benzofuran chloroform solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1949404: Experimental Crystal Structure Determination

2020

Related Article: Joshua E. Barker, Justin J. Dressler, Abel Cárdenas Valdivia, Ryohei Kishi, Eric T. Strand, Lev N. Zakharov, Samantha N. MacMillan, Carlos J. Gómez-García, Masayoshi Nakano, Juan Casado, Michael M. Haley|2019|J.Am.Chem.Soc.|142|1548|doi:10.1021/jacs.9b11898

614-bis(4-t-butyl-26-dimethylphenyl)[1]benzothieno[2''3'':2'3']indeno[5'6':56]indeno[21-b][1]benzothiophene chloroform solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 868802: Experimental Crystal Structure Determination

2012

Related Article: A.Cornia, F.Felluga, V.Frenna, F.Ghelfi, A.F.Parsons, M.Pattarozzi, F.Roncaglia, D.Spinelli|2012|Tetrahedron|68|5863|doi:10.1016/j.tet.2012.04.117

66'-Diethyl-77'-diphenyl-22'33'-tetrahydro-5H5'H-7a7a'-bipyrrolo[21-b][13]thiazole-55'-dioneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis

2012

Monoclonal B Lymphocytosis (MBL) is defined as asymptomatic monoclonal B-cell expansion characterised by a CLL-phenotype, but with less than 5 x 10(9)/I circulating cells. Reactive oxygen species (ROS)-mediated cell damage plays a critical role in the initiation of carcinogenesis as well as in malignant transformation. The goal of this study was to perform an analysis of the oxidative stress statuses of patients affected by MBL and chronic lymphocytic leukaemia (CLL). We examined peripheral blood and urine specimens from 29 patients with MBL, 55 with CLL and 31 healthy subjects. There was a significant increase in the occurrence of the mutagenic base 8-oxo-2'-deoxiguanosine (8-oxo-dG) in th…

8-Oxo-dGMaleChronic lymphocytic leukaemiaCancer ResearchF-2-isoprostanesTime FactorsLymphocytosisDNA damageLymphocytosisBiologyDinoprostmedicine.disease_causeAntioxidantsLipid peroxidationchemistry.chemical_compoundMalondialdehydemedicineHumansCell damageChromatography High Pressure LiquidAgedchemistry.chemical_classificationB-LymphocytesReactive oxygen speciesGlutathione DisulfideDeoxyguanosineMonoclonal B LymphocytosisGlutathioneMiddle AgedMalondialdehydemedicine.diseaseGlutathioneLeukemia Lymphocytic Chronic B-CellOxidative StressOncologychemistryOxidative stress8-Hydroxy-2'-DeoxyguanosineImmunologyDNA damageFemalemedicine.symptomReactive Oxygen SpeciesBiomarkersOxidative stressDNA DamageCancer Letters
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Tuning the photophysical properties of cationic iridium(iii) complexes containing cyclometallated 1-(2,4-difluorophenyl)-1H-pyrazole through function…

2012

Four new heteroleptic iridium(III) complexes in the family [Ir(dfppz)(2)((NN)-N-boolean AND)](+), where Hdfppz = 1-(2,4-difluorophenyl)-1H-pyrazole and (NN)-N-boolean AND = 6-phenyl-2,2'-bipyridine (1), 4,4'-(di-tert-butyl)-6-phenyl-2,2'-bipyridine (2), 4,4'-(di-tert-butyl)-6,6'-diphenyl-2,2'-bipyridine (3) and 4,4'-bis(dimethylamino)-2,2'-bipyridine (4), have been synthesized as the hexafluoridophosphate salts and fully characterized. Single crystal structures of ligand 3 and the precursor [Ir-2(dfppz)(4)(mu-Cl)(2)] have been determined, along with the structures of the complexes 4{[Ir(dfppz)(2)(1)][PF6]}center dot 3CH(2)Cl(2), [Ir(dfppz)(2)(3)][PF6]center dot CH2Cl2 and [Ir(dfppz)(2)(4)][…

Absorption spectroscopyChemistryLigandAnalytical chemistrychemistry.chemical_element02 engineering and technologyNuclear magnetic resonance spectroscopyPyrazole010402 general chemistry021001 nanoscience & nanotechnology01 natural sciences22'-Bipyridine0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundCrystallographyIridiumTriplet state0210 nano-technologyAcetonitrileDalton Trans.
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Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2'-deoxyguanosine in advanced epithelial ovarian carcinoma of a Spanish community.

2006

In the present study, we describe the changes of antioxidant enzyme activities and other oxidative stress-related parameters in a mediterranean cohort of women affected with epithelial ovarian carcinoma (EOC). For that purpose, the most representative enzymatic activities, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the oxidized/reduced glutathione (GSSG/GSH) ratio have been analyzed in tumor tissue biopsies and compared with the normal tissue of the same patient. As oxidation products, the levels of malondialdehyde (MDA) as an indication of lipid peroxidation, and the DNA damaged base 8-oxo-2'-deoxyguanosine (8-oxo-dG) have been also measured. Ad…

AdultCancer Research8-Oxo-2'-deoxyguanosinemedicine.disease_causeAndrologyLipid peroxidationSuperoxide dismutasechemistry.chemical_compoundmedicineHumansNeoplasms Glandular and EpithelialAgedNeoplasm Stagingchemistry.chemical_classificationAged 80 and overOvarian NeoplasmsGlutathione PeroxidasebiologySuperoxide DismutaseGlutathione peroxidase8-Hydroxy-2'-deoxyguanosineDeoxyguanosineGlutathioneMiddle AgedMalondialdehydeCatalaseGlutathioneOncologyBiochemistrychemistry8-Hydroxy-2'-Deoxyguanosinebiology.proteinFemaleLipid PeroxidationOxidative stressDNA DamageCancer letters
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