Search results for "2(42)"

Cine y música: : sobre la consubstancialidad de las artes y el diálogo

2013

Engineering of Adult Neurogenesis and Gliogenesis

2016

Neural stem/progenitor cells (NSPCs) retain their ability to generate newborn neurons throughout life in the mammalian brain. Here, we describe how recently developed virus- and transgenesis-based techniques will help us (1) to understand the functional effects of neurogenesis in health and disease, (2) to design novel approaches to harness the potential for NSPC-associated endogenous repair, and (3) to induce the generation of neurons outside the main neurogenic niches in the adult brain.

Tres tablas más que añadir al catálogo de Vicente Macip. (Albaida, h. 1468- Valencia, 1551)

2013

Estudio de la función de los factores de transcripción PBX en la diferenciación a neurona dopaminérgica del bulbo olfatorio de ratón

2017

[EN] Dopamine signalling regulates a variety of complex behaviours and defects in dopaminergic neuron function or survival result in severe human pathologies such as Parkinson´s disease. All dopaminergic neurons are characterized by the expression of a battery of genes that code for a set of proteins required for the synthesis, release and re-uptake of dopamine and all together are called the DA pathway genes. Therefore, understanding how this set of genes are transcriptionally activated in a coordinated manner is the first step to discover the clues of dopaminergic terminal differentiation. The dopamine pathway genes are highly conserved throughout evolution. Studies in the nematode C.eleg…

Layer-Specific Refinement of Sensory Coding in Developing Mouse Barrel Cortex

2017

Rodent rhythmic whisking behavior matures during a critical period around 2 weeks after birth. The functional adaptations of neocortical circuitry during this developmental period remain poorly understood. Here, we characterized stimulus-evoked neuronal activity across all layers of mouse barrel cortex before, during, and after the onset of whisking behavior. Employing multi-electrode recordings and 2-photon calcium imaging in anesthetized mice, we tested responses to rostro-caudal whisker deflections, axial "tapping" stimuli, and their combination from postnatal day 10 (P10) to P28. Within this period, whisker-evoked activity of neurons displayed a general decrease in layer 2/3 (L2/3) and …

Universities' mundaneness and regional engagement : Setting the stage

2022

This chapter introduces the main logic of this volume, which starts from the grassroots level of universities’ “everyday” engagements, looking at the manifold ways in which university knowledge agents build connections with multiple regional partners across the public and private sectors, and civic society more generally. Roles, functions and normative orientations of universities in the context of their surrounding regions have, in many cases, been taken for granted and, thus, have not been systematically addressed and/or still lack theorizing, due to the focus being on extraordinary, large-scale and eye-catching activities, and financially impressive transactions such as patents and spin-…

Universities and regions: New insights and emerging developments

2022

In this concluding chapter, the editors take stock of the empirical findings across the cases and levels of analysis and link the empirical evidence to the analytical framework presented in Chapter 2. In so doing, we revisit the interplay between macro, meso, and micro dimensions of the environments as well as the temporality in which higher education institutions (HEIs) operate, which, taken together, help shape the mundane (everyday) or routine behaviours of actors within HEIs. The editors conclude by suggesting that the empirical evidence and conceptual insights advanced in this volume represent a needed first step, yet more needs to be done (future studies) to further unpack how the dyn…

Unpacking Mundaneness : A novel conceptual framework for universities and regional engagement

2022

In this chapter, we debate the current view on university-regional engagements and suggest a renewed theoretical framework based on four main elements – macro, meso, micro dimensions, as well as a meta-dimension of temporality that cuts across all levels. The macro environment is typically defined as pertaining to public policies, culture, laws, and economy, while the meso environment includes links between the macro (societal) forces and the micro (agents) level through intermediate institutions and structures and is characterized by the processes and mechanisms of interaction of different actors. The micro level is about agency – organizations or individuals/groups within organizations – …

m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat Substantia Nigra and Ventral Tegmental Area by activating serotonin-2c receptors

2001

In vivo electrophysiological techniques were used to study the effect of m-chlorophenylpiperazine, a non-selective serotonin-2C receptor agonist, on the activity of non-dopaminergic neurons in the substantia nigra pars reticulata and the ventral tegmental area of anesthetized rats. Intravenous administration of m-chlorophenylpiperazine (5–320 μg/kg) caused a dose-dependent increase in the basal firing rate of a subpopulation of nigral neurons which do not respond to a footpinch stimulus [P(0) neurons], whereas it did not affect the activity of neurons which are responsive to the footpinch [P(+) neurons]. However, m-chlorophenylpiperazine (5–320 μg/kg) excited all non-dopaminergic neurons sa…

Vil økt fysisk aktivitet kunne redusere andelen trygdemottakere? : En case-studie basert på deltakere ved Aktiv på dagtid, Aust-Agder

2018

Masteroppgave offentlig politikk og ledelse ME502 - Universitetet i Agder 2018 This study is based on Aktiv pådagtid as an case study. The purpose of this study is to investigate the relationship between increased participation in physical activities directed by Aktiv på dagtid and the participants status in relation to working life. To better understand the relationship between these two variables, the study include three possible predictors:health, social support and self-efficacy.Thisstudy use a paper-based survey with 144 respondents, which represent the participants atAktiv på dagtid, who are at theage between 16-70, receive social security benefits and resides in the municipalities of…