Search results for "2-amino-1"

showing 10 items of 22 documents

Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo…

2002

Abstract Chinese hamster lung fibroblasts, genetically engineered for the expression of rat cytochrome P450 dependent monooxygenase 1A2 and rat sulfotransferase 1C1 (V79-rCYP1A2-rSULT1C1 cells), were utilized to check for possible protective effects of beverages of plant origin, fruits, vegetables, and spices against genotoxicity induced by 2-acetylaminofluorene (AAF) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Antigenotoxic activities of juices from spinach and red beets against AAF could be monitored with similar effectivity by the HPRT-mutagenicity test (IC50=0.64%; 2.57%) and alkaline single cell gel electrophoresis (comet assay; IC50=0.12%; 0.89%) which detects DNA stran…

Hypoxanthine PhosphoribosyltransferaseHealth Toxicology and Mutagenesismedicine.disease_causeCell LineBeverageschemistry.chemical_compoundCricetulusCytochrome P-450 CYP1A2CricetinaeVegetablesGeneticsmedicineAnimalsWineFlavonoids2-Amino-1-methyl-6-phenylimidazo(45-b)pyridinePlants MedicinalbiologyMutagenicity TestsImidazolesfood and beveragesAntimutagenic AgentsMonooxygenase2-AcetylaminofluoreneFibroblastsbiology.organism_classificationRecombinant ProteinsRatsComet assayBiochemistrychemistryWhite WineFruitFlavanonesSpinachQuercetin2-AcetylaminofluoreneComet AssaySulfotransferasesGenotoxicityMutagensMutation research
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Stereoselective synthesis and transformation of pinane-based 2-amino-1,3-diols

2021

A library of pinane-based 2-amino-1,3-diols was synthesised in a stereoselective manner. Isopinocarveol prepared from (−)-α-pinene was converted into condensed oxazolidin-2-one in two steps by carbamate formation followed by a stereoselective aminohydroxylation process. The relative stereochemistry of the pinane-fused oxazolidin-2-one was determined by 2D NMR and X-ray spectroscopic techniques. The regioisomeric spiro-oxazolidin-2-one was prepared in a similar way starting from the commercially available (1R)-(−)-myrtenol (10). The reduction or alkaline hydrolysis of the oxazolidines, followed by reductive alkylation resulted in primary and secondary 2-amino-1,3-diols, which underwent a reg…

ScienceAlkaline hydrolysis (body disposal)Alkylation2-amino-12-diol010402 general chemistryRing (chemistry)01 natural sciencesFull Research PaperBenzaldehydechemistry.chemical_compoundQD241-441monoterpeenitOrganic chemistryorgaaniset yhdisteetkemiallinen synteesistereoselective010405 organic chemistryQOrganic ChemistryRegioselectivityTautomer0104 chemical sciencesChemistrytautomerismchemistryoxazolidin-2-oneStereoselectivityTwo-dimensional nuclear magnetic resonance spectroscopytautomeriamonoterpeneBeilstein Journal of Organic Chemistry
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CCDC 1005273: Experimental Crystal Structure Determination

2014

Related Article: Michael Giese, Markus Albrecht, Arto Valkonen, Kari Rissanen|2015|Chemical Science|6|354|doi:10.1039/C4SC02762K

Space GroupCrystallographyCrystal SystemCrystal Structure2-Amino-1-(pentafluorobenzyl)pyridinium bromideCell ParametersExperimental 3D Coordinates
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CCDC 1519805: Experimental Crystal Structure Determination

2017

Related Article: Petra Vasko, Juha Hurmalainen, Akseli Mansikkamäki, Anssi Peuronen, Aaron Mailman, Heikki M. Tuononen|2017|Dalton Trans.|46|16004|doi:10.1039/C7DT03243A

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-amino-1-methyl-6-[(3-sulfanylidene-34-dihydropyrazin-2-yl)amino]pyridin-1-ium trifluoromethanesulfonateExperimental 3D Coordinates
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CCDC 1536801: Experimental Crystal Structure Determination

2017

Related Article: Petra Vasko, Juha Hurmalainen, Akseli Mansikkamäki, Anssi Peuronen, Aaron Mailman, Heikki M. Tuononen|2017|Dalton Trans.|46|16004|doi:10.1039/C7DT03243A

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates2-amino-1-methyl-6-[(3-sulfanylidene-34-dihydroquinoxalin-2-yl)amino]pyridin-1-ium trifluoromethanesulfonate
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CCDC 1578276: Experimental Crystal Structure Determination

2018

Related Article: Álvaro Sanz-Vidal, Javier Torres, Vadim A. Soloshonok, Yi Zhu, Jianlin Han, Santos Fustero, Carlos del Pozo|2018|Adv.Synth.Catal.|360|366|doi:10.1002/adsc.201701284

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D CoordinatesN-{1-[1-(2-amino-1-cyanoethenyl)-1234-tetrahydronaphthalen-2-yl]-222-trifluoroethyl}-2-methylpropane-2-sulfonamide dichloromethane solvate
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CCDC 1982665: Experimental Crystal Structure Determination

2023

Related Article: Antonin Jaillet, Christophe Darcel, Jérôme Bayardon, Adrien Schlachter, Christine Salomon, Yoann Rousselin, Pierre Harvey, Sylvain Jugé|2020|J.Org.Chem.|85|14391|doi:10.1021/acs.joc.0c00536

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-((biphenyl-2-yl)phenyl(trihydridoborato)phosphonio)-O-((trihydridoborato)diphenylphosphonio)-N-methyl-2-amino-1-phenylpropanolateExperimental 3D Coordinates
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CCDC 1982663: Experimental Crystal Structure Determination

2023

Related Article: Antonin Jaillet, Christophe Darcel, Jérôme Bayardon, Adrien Schlachter, Christine Salomon, Yoann Rousselin, Pierre Harvey, Sylvain Jugé|2020|J.Org.Chem.|85|14391|doi:10.1021/acs.joc.0c00536

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-((biphenyl-2-yl)phenyl(trihydridoborato)phosphonio)-O-((trihydridoborato)diphenylphosphonio)-N-methyl-2-amino-1-phenylpropanolateExperimental 3D Coordinates
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CCDC 1982662: Experimental Crystal Structure Determination

2023

Related Article: Antonin Jaillet, Christophe Darcel, Jérôme Bayardon, Adrien Schlachter, Christine Salomon, Yoann Rousselin, Pierre Harvey, Sylvain Jugé|2020|J.Org.Chem.|85|14391|doi:10.1021/acs.joc.0c00536

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(diphenyl(trihydridoborato)phosphonio)-O-((naphthalenyl)(trihydridoborato)phenylphosphonio)-N-methyl-2-amino-1-phenylpropanolateExperimental 3D Coordinates
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CCDC 1982660: Experimental Crystal Structure Determination

2023

Related Article: Antonin Jaillet, Christophe Darcel, Jérôme Bayardon, Adrien Schlachter, Christine Salomon, Yoann Rousselin, Pierre Harvey, Sylvain Jugé|2020|J.Org.Chem.|85|14391|doi:10.1021/acs.joc.0c00536

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(diphenyl(trihydridoborato)phosphonio)-O-(o-tolyl(trihydridoborato)phenylphosphonio)-N-methyl-2-amino-1-phenylpropanolateExperimental 3D Coordinates
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