Search results for "2-b"

showing 10 items of 560 documents

C3 Drives Inflammatory Skin Carcinogenesis Independently of C5

2021

Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (cSCC) is the most common form of cancer and can occur as a consequence of DNA damage to the epithelium by UVR or chemical carcinogens. There is growing evidence that the complement system is involved in cancer immune surveillance; however, its role in cSCC remains unclear. Here, we show that complement genes are expressed in tissue from patients with cSCC, and C3 activation fragments are present in cSCC biopsies, indicating complement activation. Using a range of complement-deficient mice in a two-stage mouse model of chemically-induced cSCC, where a subclinical dose of 7,12-dimethylbenz[a]anthracene causes oncogenic mutatio…

0301 basic medicineWT wild typeSkin NeoplasmsComplement receptorComplement Membrane Attack Complexmedicine.disease_causeBiochemistrychemistry.chemical_compoundMice0302 clinical medicineCR complement receptorComplement ActivationSkinMice KnockoutcSCC cutaneous squamous cell carcinomaComplement C5Complement C3Receptors Complement030220 oncology & carcinogenesisCarcinoma Squamous CellDisease ProgressionTumor BiologyOriginal ArticleMAC membrane attack complexSignal TransductionHPV16 human papillomavirus type 16910-Dimethyl-12-benzanthraceneTPA 12-O-tetradecanoylphorbol-13-acetateMice TransgenicDermatologySettore MED/08 - Anatomia Patologica03 medical and health sciencesmedicineAnimalsHumansC3Molecular BiologyReceptor Anaphylatoxin C5aDMBA 712-dimethylbenz[a]anthracenebusiness.industry712-Dimethylbenz[a]anthraceneCancerCell BiologyNeoplasms Experimentalmedicine.diseaseComplement systemDisease Models Animal030104 developmental biologychemistryTumor progressionCancer researchCarcinogensTumor EscapeSkin cancerbusinessCarcinogenesisComplement membrane attack complexSkin carcinogenesis.EC epithelial cell
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CCDC 244402: Experimental Crystal Structure Determination

2005

Related Article: C.M.Grunert, P.Weinberger, J.Schweifer, C.Hampel, A.F.Stassen, K.Mereiter, W.Linert|2005|J.Mol.Struct.|733|41|doi:10.1016/j.molstruc.2004.07.036

112-bis(1H-Tetrazolyl)dodecaneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 629492: Experimental Crystal Structure Determination

2007

Related Article: C.A.Jimenez, J.B.Belmar, J.Alderete, F.S.Delgado, M.Lopez-Rodriguez, O.Pena, M.Julve, C.Ruiz-Perez|2007|Dalton Trans.||2135|doi:10.1039/b617604f

12-bis(35-Di-t-butyl-2-hydroxybenzamido)ethaneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 986491: Experimental Crystal Structure Determination

2014

Related Article: Albert Ferrer-Ugalde, Arántzazu González-Campo, Clara Viñas, Jesús Rodríguez-Romero, Rosa Santillan, Norberto Farfán, Reijo Sillanpää, Antonio Sousa-Pedrares, Rosario Núñez, Francesc Teixidor|2014|Chem.-Eur.J.|20|9940|doi:10.1002/chem.201402396

12-bis(Anthracen-9-ylmethyl)-12-dicarba-closo-dodecaborane dichloromethane solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1935935: Experimental Crystal Structure Determination

2020

Related Article: Rakesh Puttreddy, J. Mikko Rautiainen, Toni Mäkelä, Kari Rissanen|2019|Angew.Chem.,Int.Ed.|58|18610|doi:10.1002/anie.201909759

1H-12-benzothiazole-113(2H)-trione -2-phenyl-1--pyridine N-oxdeSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1935934: Experimental Crystal Structure Determination

2020

Related Article: Rakesh Puttreddy, J. Mikko Rautiainen, Toni Mäkelä, Kari Rissanen|2019|Angew.Chem.,Int.Ed.|58|18610|doi:10.1002/anie.201909759

1H-12-benzothiazole-113(2H)-trione 26-dimethyl-1-pyridine N-oxideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 658271: Experimental Crystal Structure Determination

2008

Related Article: K.Salorinne, M.Nissinen|2008|Tetrahedron|64|1798|doi:10.1016/j.tet.2007.11.103

281420-Tetraethyl-6121824-tetramethoxy-410:1622-bis(22'-(p-phenylenebis(methyleneoxy-o-phenoxy)diethoxy))calix(4)arene chloroform solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoyl…

2004

Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1 H and 1 3 C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [Cu I I (2-BZP) 2 ] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [Cu I I (2-BZP) 2 ] and [Pt I I (2-BZP) 2 ] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 μM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10…

2-BenzoylpyrroleCopper(II) and platinum(II) complexesCytotoxicityMagnetic Resonance SpectroscopySpectrophotometry InfraredCell SurvivalMolecular Conformationchemistry.chemical_elementAntineoplastic AgentsCrystal structureCrystallography X-RayLigandsBiochemistryJurkat cellsInorganic ChemistryJurkat CellsOrganometallic CompoundsHumansPyrrolesCytotoxicityCoordination geometryPlatinumFormazansCell DeathDose-Response Relationship DrugMolecular StructureX-rayHydrogen Bonding2-benzoylpyrrole; copper(ii) and platinum(ii) complexes; cytotoxicityCarbon-13 NMRFlow CytometryCopperCrystallographycopper(ii) and platinum(ii) complexeschemistryxray cristallogrphycytotoxicityIndicators and ReagentsPlatinumCopper2-benzoylpyrroleJournal of inorganic biochemistry
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CCDC 1426140: Experimental Crystal Structure Determination

2016

Related Article: Rakesh Puttreddy, Ondřej Jurček, Sandip Bhowmik, Toni Mäkelä, Kari Rissanen|2016|Chem.Commun.|52|2338|doi:10.1039/C5CC09487A

2-Iodo-12-benzothiazol-3(2H)-one 11-dioxide 2-methylpyridine 1-oxideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1520500: Experimental Crystal Structure Determination

2018

Related Article: Monika Olesiejuk, Agnieszka Kudelko, Katarzyna Gajda, Błażej Dziuk, Krzysztof Ejsmont|2018|Z.Naturforsch.,B:Chem.Sci.|73|577|doi:10.1515/znb-2018-0072

2-benzoyl-5-phenylpyrazolidin-3-oneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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