Search results for "2-phenyl-1"

showing 10 items of 32 documents

SYNTHESIS OF 3-(2-PHENYL-1,3-THIAZOL-4-YL)-1H-INDOLES, NEW DERIVATIVES WITH POTENTIAL ANTINEOPLASTIC ACTIVITY

2008

3-(2-PHENYL-13-THIAZOL-4-YL)-1H-INDOLESSettore CHIM/08 - Chimica Farmaceutica
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Synthesis and Antitumor Activity of 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-indoles and 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-7-azaindoles

2011

Given the potent antimicrobial, antiviral, and antitumor activities of many natural products, there is an increasing interest in the synthesis of new molecules based on natural compound scaffolds. Based on a 2,4-bis(3'-indolyl)imidazole skeleton, two new series of phenylthiazolylindoles and phenylthiazolyl-7-azaindoles were obtained by Hantzsch reaction between substituted phenylthioamides and the α-bromoacetyl derivatives. Some azaindole derivatives, tested at the National Cancer Institute against a panel of ∼60 tumor cell lines derived from nine human cancer cell types, showed inhibitory effects against all cell lines investigated at micromolar to nanomolar concentrations. Two of them exh…

IndolesStereochemistry3-(2-Phenyl-1; 3-thiazol-4-yl)-1H-indoles; 3-(2-Phenyl-1; 3-thiazol-4-yl)-1H-7-azaindoles; Nortopsentins; Antitumor activityAntineoplastic AgentsTumor cells3-thiazol-4-yl)-1H-7-azaindolesBiochemistry3-(2-Phenyl-13-thiazol-4-yl)-1H-indolechemistry.chemical_compoundCell Line TumorNeoplasmsCDC2 Protein KinaseDrug DiscoveryHumansImidazoleGeneral Pharmacology Toxicology and PharmaceuticsProtein Kinase InhibitorsPharmacologyAntitumor activityNortopsentins3-thiazol-4-yl)-1H-indolesChemistryKinaseNatural compoundNortopsentinOrganic Chemistry3-(2-Phenyl-1AntimicrobialCombinatorial chemistryThiazolesCell culture3-(2-Phenyl-13-thiazol-4-yl)-1H-7-azaindoleMolecular MedicineDrug Screening Assays AntitumorAntitumor activityHuman cancer
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CCDC 263594: Experimental Crystal Structure Determination

2005

Related Article: A.Laromaine, F.Teixidor, R.Kivekas, R.Sillanpaa, R.Benakki, B.Gruner, C.Vinas|2005|Dalton Trans.||1785|doi:10.1039/b502328a

Space GroupCrystallographybis(2-phenyl-12-dicarba-closo-dodecaboranyl)disulfideCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1835925: Experimental Crystal Structure Determination

2018

Related Article: Alexandre Abhervé, Samia Benmansour, Carlos José Gómez-García, Narcis Avarvari|2018|CrystEngComm|20|4141|doi:10.1039/C8CE00561C

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinatesoxonium tris(2-phenyl-1H-imidazo[45-f][110]phenanthrolinate)-cobalt(ii) diethyl ether solvate pentahydrate
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CCDC 764362: Experimental Crystal Structure Determination

2010

Related Article: T.Voss, Chao Chen, G.Kehr, E.Nauha, G.Erker, D.W.Stephan|2010|Chem.-Eur.J.|16|3005|doi:10.1002/chem.200903483

Space GroupCrystallographytris(Pentafluorophenyl)(115-trimethyl-2-phenyl-1H-indolium-3-yl)borate dichloromethane solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1835922: Experimental Crystal Structure Determination

2018

Related Article: Alexandre Abhervé, Samia Benmansour, Carlos José Gómez-García, Narcis Avarvari|2018|CrystEngComm|20|4141|doi:10.1039/C8CE00561C

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersoxonium tris(2-phenyl-1H-imidazo[45-f][110]phenanthrolinate)-iron(ii) diethyl ether tetrahydrateExperimental 3D Coordinates
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CCDC 601854: Experimental Crystal Structure Determination

2007

Related Article: T.S.B.Baul, W.Rynjah, E.Rivarola, A.Lycka, M.Holcapek, R.Jirasko, D.de Vos, R.J.Butcher, A.Linden|2006|J.Organomet.Chem.|691|4850|doi:10.1016/j.jorganchem.2006.08.005

Space GroupCrystallographyCrystal Systembis(mu~3~-oxo)-bis(mu~2~-(E)-2-hydroxy-5-(2-phenyl-1-diazenyl)benzoato)-bis((E)-2-hydroxy-5-(2-phenyl-1-diazenyl)benzoato)-octa-n-butyl-tetra-tinCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1935912: Experimental Crystal Structure Determination

2020

Related Article: Rakesh Puttreddy, J. Mikko Rautiainen, Toni Mäkelä, Kari Rissanen|2019|Angew.Chem.,Int.Ed.|58|18610|doi:10.1002/anie.201909759

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-bromo-1H-12-benzothiazole-113(2H)-trione 2-phenyl-1-pyridine N-oxideExperimental 3D Coordinates
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CCDC 149081: Experimental Crystal Structure Determination

2002

Related Article: T.S.B.Baul, S.Dhar, S.M.Pyke, E.R.T.Tiekink, E.Rivarola, R.Butcher, F.E.Smith|2001|J.Organomet.Chem.|633|7|doi:10.1016/S0022-328X(01)01024-5

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(5-((E)-2-Phenyl-1-diazenyl)-2-hydroxybenzoato-O)-triphenyl-tin(iv)Experimental 3D Coordinates
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CCDC 841710: Experimental Crystal Structure Determination

2011

Related Article: R.D.Costa, E.Orti, H.J.Bolink, S.Graber, C.E.Housecroft, E.C.Constable|2011|Chem.Commun.|47|3207|doi:10.1039/c0cc05084a

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2-Phenyl-110-phenanthroline)-(bis(2-(pyridin-2-yl)phenyl))-iridium hexafluorophosphate dihydrateExperimental 3D Coordinates
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