Search results for "21"
showing 10 items of 34876 documents
CERN IRRADIATION FACILITIES.
2017
CERN provides unique irradiation facilities for applications in dosimetry, metrology, intercomparison of radiation protection devices, benchmark of Monte Carlo codes and radiation damage studies to electronics.
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
Transcranial Alternating Current Stimulation (tACS) Does Not Affect Sports People’s Explosive Power: A Pilot Study
2021
Purpose: This study is aimed to preliminary investigate whether transcranial alternating current stimulation (tACS) could affect explosive power considering genetic background in sport subjects.Methods: Seventeen healthy sports volunteers with at least 3 years of sports activities participated in the experiment. After 2 weeks of familiarization performed without any stimulation, each participant received either 50 Hz-tACS or sham-tACS. Before and after stimulation, subjects performed the following tests: (1) the squat jump with the hands on the hips (SJ); (2) countermovement jump with the hands on the hips (CMJ); (3) countermovement jump with arm swing (CMJ-AS); (4) 15-s Bosco’s test; (5) s…
Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm
2014
Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…
How many longitudinal covariate measurements are needed for risk prediction?
2014
Abstract Objective In epidemiologic follow-up studies, many key covariates, such as smoking, use of medication, blood pressure, and cholesterol, are time varying. Because of practical and financial limitations, time-varying covariates cannot be measured continuously, but only at certain prespecified time points. We study how the number of these longitudinal measurements can be chosen cost-efficiently by evaluating the usefulness of the measurements for risk prediction. Study Design and Setting The usefulness is addressed by measuring the improvement in model discrimination between models using different amounts of longitudinal information. We use simulated follow-up data and the data from t…
Supporting Cyber Resilience with Semantic Wiki
2016
Cyber resilient organizations, their functions and computing infrastructures, should be tolerant towards rapid and unexpected changes in the environment. Information security is an organization-wide common mission; whose success strongly depends on efficient knowledge sharing. For this purpose, semantic wikis have proved their strength as a flexible collaboration and knowledge sharing platforms. However, there has not been notable academic research on how semantic wikis could be used as information security management platform in organizations for improved cyber resilience. In this paper, we propose to use semantic wiki as an agile information security management platform. More precisely, t…
T9+HUD: Physical Keypad and HUD can Improve Driving Performance while Typing and Driving
2016
We introduce T9+HUD, a text entry method designed to decrease visual distraction while driving and typing. T9+HUD combines a physical 3x4 keypad on the steering wheel with a head-up-display (HUD) for projecting output on the windshield. Previous work suggests this may be a visually less demanding way to type while driving than the popular case which requires shifts of visual attention away from the road. We present a prototype design and report first results from a controlled evaluation in a driving simulator. While driving, the T9+HUD text entry rate was equal compared to a dashboard-mounted touchscreen device, but it reduced lane deviations by 70%. Furthermore, there was no significant di…
Voice traffic bicasting enhancements in mobile HSPA network
2014
This paper discusses methods for improving the effectiveness of delivering voice traffic over High-Speed Downlink Packet Access (HSDPA) network by employing transmission diversity with Single-Frequency Dual-Cell (SF-DC) Aggregation that is part of the Multiflow specification. SF-DC Aggregation allows the user to be served at the same time by two different cells. The enhancements discussed in the paper capitalize strongly on the availability of the composed Channel Quality Indication (CQI) feedback at both serving cells. According to the results obtained from the network simulations, the ability to select the better channel for each voice transmission significantly decreases the required tra…
How Students Get Going : Triggers for Students’ Learning in Project-Based Education
2018
Repeatedly documented positive student responses to project-based learning during its decades-long tradition in CS attest to the effectiveness of learning by doing. Support for reflective learning nevertheless continues to be a topic worth studying because the intensity of project work together with a high technical orientation among CS students often complicate reflective practice. A critical incident-inspired assignment was added to a project-based course to support reflective practice in spring 2017. In a previous study, the authors analyzed how students approached the assignment and whether they found it supportive for learning. The present study content-analyses the situations that tri…