Search results for "21"
showing 10 items of 34876 documents
Online support for vulnerable consumers: a safe place?
2017
Purpose This paper aims to examine the service experience in an online support community of consumers to understand the nature of social support and how it is experienced and enacted by vulnerable consumers. Design/methodology/approach A netnographic study was conducted to examine vulnerable consumers’ participation in an online support group for weight management. The Linguistic Inquiry Word Count (LIWC) program was used, and additionally data were coded using open coding. A hybrid approach to data analysis was undertaken using inductive and deductive methods. Findings The findings suggest online social support groups can be used as an online “third place” to support vulnerable consumers, …
Structure and dynamics in liquid bismuth and Bin clusters: A density functional study
2014
Density functional/molecular dynamics simulations with more than 500 atoms have been performed on liquid bismuth at 573, 773, 923, and 1023 K and on neutral Bi clusters with up to 14 atoms. There are similar structural patterns (coordination numbers, bond angles, and ring patterns) in the liquid and the clusters, with significant differences from the rhombohedral crystalline form. We study the details of the structure (structure factor, pair, and cavity distribution functions) and dynamical properties (vibration frequencies, diffusion constants, power spectra), and compare with experimental results where available. While the three short covalent bonds typical to pnictogens are characteristi…
Aktywność sołectw wspierających rozwój społeczny w ramach Programu Odnowy Wsi w latach 2013-2015
2018
Odnowa wsi jako metoda rozwoju stanowi jeden ze sposobów osiągania celów rozwojowych, rozumianych nie tylko w kontekście poprawy jakości infrastruktury, ale poprawy szeroko rozumianej jakości życia, której nie osiągniemy bez zaangażowania samych mieszkańców. Celem artykułu jest przedstawienie Programu Odnowy Wsi (na przykładzie województwa opolskiego) jako elementu przyczyniającego się do rozwoju kapitału społecznego, czego wyrazem może być liczba przedsięwzięć realizowanych przez poszczególne sołectwa. Zostały przeanalizowane sprawozdania sołectw (około 600 rocznie) z realizacji programu w latach 2013-2015. Podstawową metodą prezentacji wyników badań jest analiza opisowa z użyciem metod il…
Medical masks and Respirators for the Protection of Healthcare Workers from SARS-CoV-2 and other viruses
2020
The use of medical masks and respirators as personal protective equipment is pivotal to reducing the level of biological hazard to which healthcare workers are exposed during the outbreak of highly diffusible pathogens, such as the recent novel coronavirus SARS-CoV-2. Unfortunately, during this pandemic, supplies are rapidly running out worldwide, with potential consequences for the rate of occupational infections. Also, knowledge about specific characteristics of respirators is of utmost importance to select the proper type according to the clinical setting. A wide variety of literature is available on the topic, but mostly based on Influenza viruses infection models. Clinical evidence on …
Meme marketing: How marketers can drive better engagement using viral memes?
2022
Scholars and industry stakeholders have exhibited an interest in identifying the underlying dimensions of viral memes. However, the recipe for creating a viral meme remains obscure. This study makes a phenomenological contribution by examining viral memes, exploring the antecedents (i.e., content-related factors, customer-related factors, and media-related factors), consequences, and moderating factors using a mixed-method approach. The study presents a holistic framework for creating viral memes based on the perceptions of customers and industry stakeholders. Four quantitative studies (i.e., a lab experiment, an online quasi-experiment, an event study, and a brand recall study) validate th…
Helppoa vai vaikeaa arvioida? : Yleisten kielitutkintojen suomen kielen arvioijien käsityksiä vironkielisten arvioinnista
2016
Finnish raters’ beliefs about assessing Estonian speakers in a Finnish language test: easy or difficult? This paper aims to contribute to our understanding on rater beliefs and views and to promote transparency in rater’s work in the form of reflection. The paper focuses on professional Finnish raters’ beliefs and views of assessing L1 Estonian speakers in the criteria-referenced Finnish language test of the National Certifi- cates of Language Proficiency test system. Finnish raters (N = 27) were asked via email to shortly reflect on what they find easy and what difficult in rating Estonian speakers’ writing and speaking skills in the Finnish language test. The raters reflected on many issu…
Internalization of novel non-viral vector TAT-streptavidin into human cells
2007
BMC Biotechnology, 7 (1)
Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix
2019
Abstract Coat protein (COP) I and COP II complexes are involved in the transport of proteins between the endoplasmic reticulum and the Golgi apparatus in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a type I transmembrane protein. Oligomerization of p24 monomers was suggested to be mediated and/or stabilized via interactions within the transmembrane domain, and the p24 transmembrane helix appears to selectively bind a single sphingomyelin C18:0 molecule. Furthermore, a potential cholesterol-binding sequence has also been predicted in the p24 transmembrane domain. Thus, sphingomyelin and/or cholestero…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…