Search results for "231"
showing 5 items of 335 documents
Reescritura de las fuentes y sustituciones léxicas en el De Proprietate Animalium de Manuel Files: ¿variación estilística o cambio de nivel lingüísti…
2020
El De Proprietate Animalium de Manuel Files es un poema didáctico del s. XIV que parafrasea libremente varias fuentes literarias de contenido zoológico, entre las que destaca la Historia Animalium de Claudio Eliano. Un análisis detallado de los procedimientos de sustitución léxica realizado por el autor, apoyado en la consulta de los diccionarios bizantinos, permite reconocer su originalidad compositiva, la riqueza expresiva de su vocabulario poético, pero también la clara conciencia de la existencia de diferentes niveles de lengua y de los muy diversos registros utilizados por el autor.
Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
2020
Funding: Transgène; International audience; Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5-based vaccine that expresses HBV polymerase and domains of core and surface antigen and has shown immunogenicity and antiviral effects in mice. We performed a phase 1 clinical trial to assess safety and explore immunogenicity and early efficacy of TG1050 in CHB patients. This randomized, double blind, placebo-controlled study included two sequential phases: one single dose cohort (SD, n = 12) and one …
Euclid preparation: XI. Mean redshift determination from galaxy redshift probabilities for cosmic shear tomography
2021
Ilbert, O., et al. (Euclid Collaboration)
Pressure-Dependent Tuning of Photoluminescence and Size Distribution of Carbon Nanodots for Theranostic Anticancer Applications
2020
Carbon nanodots (CDs) have recently attracted attention in the field of nanomedicine because of the biocompatibility, cost-effective nature, high specific surface, good near infrared (NIR) photothermal conversion into heat and tunable fluorescence properties, which have paved the way toward incorporating use of CDs into innovative anticancer theranostic platforms. However, a reliable synthesis of CDs with established and controlled physiochemical proprieties is precluded owing to the lack of full manipulation of thermodynamic parameters during the synthesis, thus limiting their use in real world medical applications. Herein, we developed a robust solvothermal protocol which allow fine contr…
ABC saimes gēnu ekspresija un vēža cilmes šūnu fenotipiskās izpausmes pret doksorubicīnu rezistentā MDA-MB-231 apakšpopulācijā
2018
Rezistence pret citotoksiskiem ķīmijterapijas savienojumiem ir nozīmīga problēma vēža ārstēšanā, kam raksturīga audzēja atjaunošanās un slimības progresēšana. Rezistenci pret ķīmijterapijas savienojumiem var veidot dažādi šūnu mehānismi, no kuriem visplašāk aprakstīta ATF saistošās kasetes (ABC) transportproteīnu pārekspresija. Rezistenci visbiežāk veicina pret ķīmijterapijas savienojumiem rezistentu apakšpopulāciju selekcija. Vēža cilmes šūnām (VCŠ) piemīt spēja izvairīties no ķīmijterapijas ietekmes un atjaunot audzēja šūnu populāciju. Darba mērķis bija noteikt ABC saimes gēnu ekspresiju un raksturot VCŠ raksturīgās pazīmes pret doksorubicīnu rezistentā trīskārši negatīva krūts vēža šūnu …