Search results for "25.03"

showing 10 items of 13 documents

In silico identification of small molecules as new cdc25 inhibitors through the correlation between chemosensitivity and protein expression pattern

2021

The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as Cdc25 modulators by applying a mixed ligand-structure-based approach and taking advantage of the correlation between the chemosensitivity of selected structures and the protein expression pattern of the proposed target. In the first step of the in silico protocol, a set of molecules acting as Cdc25 inhibitors were identified through a new ligand-based protocol and the evaluation of a large database of molecular structures. Subsequently, induced-fit docking (IFD) studies allowed us…

0301 basic medicineHepG2Protein familyCdc25In silicoAntiproliferative activityCell cycleLigandsCatalysisArticleInorganic Chemistrylcsh:Chemistry03 medical and health sciencesCdc250302 clinical medicineCDC2 Protein KinaseDrug DiscoveryHumanscdc25 PhosphatasesComputer SimulationMolecular Targeted TherapyPhysical and Theoretical ChemistryPhosphorylationMolecular Biologylcsh:QH301-705.5DRUDITSpectroscopyBinding SitesbiologyCell growthChemistryOrganic ChemistryGeneral MedicineHep G2 CellsCell cycleAntiproliferative activity; Cdc25; Cell cycle; DRUDIT; HepG2; Molecular dockingLigand (biochemistry)Small moleculeComputer Science Applications030104 developmental biologyBiochemistrylcsh:Biology (General)lcsh:QD1-999Docking (molecular)030220 oncology & carcinogenesisMolecular dockingbiology.proteinDrug Screening Assays Antitumor
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The influence of Sb doping on the local structure and disorder in thermoelectric ZnO:Sb thin films

2023

The experiment at HASYLAB/DESY was performed within the project I-20200161 EC. The research leading to this result has been supported by the project CALIPSOplus under the Grant Agreement 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020. Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union's Horizon 2020 Framework Programme H2020-WIDESPREAD-01–2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2. This work was carried out in part through the use of the INL Advanced Electron Microscopy, Imaging and Spectroscopy Facility. This work (proposal ID 2018–020-022469) was car…

AntimonyHistoryTechnologyPolymers and PlasticsThin filmsThermoelectricMechanical EngineeringMetals and AlloysSputtering:NATURAL SCIENCES::Physics [Research Subject Categories]540X-ray absorptionIndustrial and Manufacturing EngineeringMechanics of Materials2021-025-030112ddc:540Materials ChemistryBusiness and International ManagementToF-SIMSDoped zinc oxideddc:600
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CCDC 1042083: Experimental Crystal Structure Determination

2015

Related Article: Kaisa Helttunen, Tiia-Riikka Tero, Maija Nissinen|2015|CrystEngComm|17|3667|doi:10.1039/C5CE00311C

Space GroupCrystallographyCrystal System6243048-tetramethoxy-2265154-tetramethyl-9121518213336394245-decaoxaheptacyclo[27.19.3.3525.038.02253.02732.04650]tetrapentaconta-1(48)3572224272931464952-dodecaene chloroform solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1042079: Experimental Crystal Structure Determination

2015

Related Article: Kaisa Helttunen, Tiia-Riikka Tero, Maija Nissinen|2015|CrystEngComm|17|3667|doi:10.1039/C5CE00311C

Space GroupCrystallographyCrystal SystemCrystal Structure6243048-tetramethoxy-2265154-tetramethyl-9121518213336394245-decaoxaheptacyclo[27.19.3.3525.038.02253.02732.04650]tetrapentaconta-1(48)3572224272931464952-dodecaeneCell ParametersExperimental 3D Coordinates
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CCDC 1042080: Experimental Crystal Structure Determination

2015

Related Article: Kaisa Helttunen, Tiia-Riikka Tero, Maija Nissinen|2015|CrystEngComm|17|3667|doi:10.1039/C5CE00311C

Space GroupCrystallographyCrystal SystemCrystal Structure6243048-tetramethoxy-2265154-tetramethyl-9121518213336394245-decaoxaheptacyclo[27.19.3.3525.038.02253.02732.04650]tetrapentaconta-1(48)3572224272931464952-dodecaeneCell ParametersExperimental 3D Coordinates
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CCDC 1042085: Experimental Crystal Structure Determination

2015

Related Article: Kaisa Helttunen, Tiia-Riikka Tero, Maija Nissinen|2015|CrystEngComm|17|3667|doi:10.1039/C5CE00311C

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(mu-630-dimethoxy-2265154-tetramethyl-24-(methoxy)-48-(methoxy)-9121518213336394245-decaoxaheptacyclo[27.19.3.3525.038.02253.02732.04650]tetrapentaconta-1(48)3572224272931464952-dodecaene)-di-silver hexafluorophosphate hydrofluoride acetone solvate hydrateExperimental 3D Coordinates
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CCDC 1042081: Experimental Crystal Structure Determination

2015

Related Article: Kaisa Helttunen, Tiia-Riikka Tero, Maija Nissinen|2015|CrystEngComm|17|3667|doi:10.1039/C5CE00311C

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters6243048-tetramethoxy-2265154-tetramethyl-9121518213336394245-decaoxaheptacyclo[27.19.3.3525.038.02253.02732.04650]tetrapentaconta-1(48)3572224272931464952-dodecaene acetonitrile solvateExperimental 3D Coordinates
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CCDC 1042086: Experimental Crystal Structure Determination

2015

Related Article: Kaisa Helttunen, Tiia-Riikka Tero, Maija Nissinen|2015|CrystEngComm|17|3667|doi:10.1039/C5CE00311C

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersaqua-(6243048-tetramethoxy-2265154-tetramethyl-9121518213336394245-decaoxaheptacyclo[27.19.3.3525.038.02253.02732.04650]tetrapentaconta-1(48)3572224272931464952-dodecaene)-silver(i) trifluoromethanesulfonate ethanol solvate sesquihydrateExperimental 3D Coordinates
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Evaluation agroécologique de systèmes de culture en zone tropicale humide : Cas de la mise en valeur agricole d'une savane herbacée acide (Plaine des…

2013

Dans les régions tropicales humides, concilier intensification agricole et protection des ressources naturelles est un défi majeur et difficile à relever. Dans les savanes acides du nord-est laotien, des systèmes de culture de semis direct sur couverture végétale (SCV), basés sur les trois principes du non-labour, d’une couverture permanente du sol, et sur la pratique de rotations culturales diversifiées, sont proposés comme alternative technique à l’intensification agricole conventionnelle basée sur le labour. Si ces systèmes ont connu une diffusion importante et rapide dans les grandes agricultures mécanisées, leur diffusion reste néanmoins à ce jour limitée en contexte de petite agricult…

[SDE] Environmental SciencesH01 - Protection des végétaux - Considérations généralesSemis directhttp://aims.fao.org/aos/agrovoc/c_28568http://aims.fao.org/aos/agrovoc/c_28766solF08 - Systèmes et modes de culturesavane tropicale acideagroécologieBiologie du solhttp://aims.fao.org/aos/agrovoc/c_7193Performance de cultureNon-travail du sol[SDV.BV] Life Sciences [q-bio]/Vegetal Biologyhttp://aims.fao.org/aos/agrovoc/c_2018Savanehttp://aims.fao.org/aos/agrovoc/c_8511http://aims.fao.org/aos/agrovoc/c_3145http://aims.fao.org/aos/agrovoc/c_35657Petite agricultureévaluation agroécologiquehttp://aims.fao.org/aos/agrovoc/c_7182Sol acidehttp://aims.fao.org/aos/agrovoc/c_25803http://aims.fao.org/aos/agrovoc/c_1919http://aims.fao.org/aos/agrovoc/c_765http://aims.fao.org/aos/agrovoc/c_92381[SDV] Life Sciences [q-bio]Pratique culturaleLaosagriculture de conservationhttp://aims.fao.org/aos/agrovoc/c_7979Micro-organisme du solhttp://aims.fao.org/aos/agrovoc/c_89Zone tropicaleP33 - Chimie et physique du solÉcologieExploitation agricole familialehttp://aims.fao.org/aos/agrovoc/c_37938Spectroscopie infrarougeChampignonAnalyse coût avantageCulture sous couvert végétalMatière organique du solhttp://aims.fao.org/aos/agrovoc/c_36167http://aims.fao.org/aos/agrovoc/c_4176http://aims.fao.org/aos/agrovoc/c_12076http://aims.fao.org/aos/agrovoc/c_35199Propriété physicochimique du solécologie microbienneBacteriaProductivité des terressemis direct sur couverture végétaleP35 - Fertilité du solÉvaluation de l'impacthttp://aims.fao.org/aos/agrovoc/c_7160P34 - Biologie du solE80 - Économie familiale et artisanaleAnalyse économiqueTaxonomiehttp://aims.fao.org/aos/agrovoc/c_25706structure agrairehttp://aims.fao.org/aos/agrovoc/c_6825http://aims.fao.org/aos/agrovoc/c_2787Système de culturehttp://aims.fao.org/aos/agrovoc/c_2469http://aims.fao.org/aos/agrovoc/c_1971http://aims.fao.org/aos/agrovoc/c_17299U30 - Méthodes de recherchePlante de culturehttp://aims.fao.org/aos/agrovoc/c_2467http://aims.fao.org/aos/agrovoc/c_1972Cycle du carbonehttp://aims.fao.org/aos/agrovoc/c_7631
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Clinical utility of antigen carbohydrate 125 for planning the optimal length of stay in acute heart failure.

2021

BACKGROUND: The optimal length of stay (LOS) in patients hospitalized for acute heart failure (AHF) remains controversial. Plasma antigen carbohydrate 125 (CA125) has emerged as a reliable proxy of congestion. We aimed to evaluate whether there is a differential impact of LOS on the risk of 6-month AHF readmission across CA125 levels. METHODS: This is a retrospective study that included 1,387 patients discharged for AHF in two third-level centers. CA125 was measured 48±24h after admission. The association between CA125 and LOS with the risk of subsequent AHF readmission at 6 months was analyzed by Cox regression analysis accounting for death as a competing event. RESULTS: The median (IQR) a…

medicine.medical_specialtyMultivariate analysisendocrine system diseasesacute heart failureCarbohydrates030204 cardiovascular system & hematologyVentricular Function LeftCA12503 medical and health sciences0302 clinical medicinelength of stayAntigenInternal medicineInternal MedicineHumansMedicineIn patient030212 general & internal medicineAgedRetrospective StudiesDifferential impactAged 80 and overHeart FailureEjection fractionbusiness.industryProportional hazards modelStroke VolumeRetrospective cohort studyLength of StayPrognosismedicine.diseasefemale genital diseases and pregnancy complicationsHeart failureAcute DiseaseFemalebusiness
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