Search results for "25"

PD-1/PD-L1 Checkpoints and Resveratrol: A Controversial New Way for a Therapeutic Strategy

2021

Simple Summary Over the last decade, immunotherapies using antibodies targeting the programmed cell death 1 (PD-1) checkpoint or its ligand, programmed death ligand 1 (PD-L1), have emerged as promising therapeutic strategies against cancer. However, some current limitations include a relatively low rate of “responders”, the high cost of the treatment, and a rare risk of hyper-progression. Currently, the main challenge is, therefore, to improve these therapies, for instance, by using combined approaches. Here, we summarize the accumulating evidence that resveratrol (RSV) plays a role in the modulation of the PD-1/PD-L1 axis in cancer cells, suggesting the potential of therapeutic strategies …

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases

2021

Simple Summary Metastasis is the main cause for cancer mortality. The most common metastatic sites of colorectal cancer (CRC) are the liver and lungs. Tumour-infiltrating lymphocytes are recognized as beneficial prognostic factors both in primary and metastatic CRC, but less is known about their reciprocal differences. The aim of our study was to evaluate immune microenvironment and its prognostic value in a series of mismatch proficient (pMMR) CRC with matched liver and lung metastases. The proportion of tumours with high immune cell infiltration together with PD-L1-positivity almost doubled in metastases compared to primary tumours. Our study confirmed the prognostic value of high ICS in …

Pediatric Endoscopic Pilonidal Sinus Treatment (PEPSiT) in Children With Pilonidal Sinus Disease: Tips and Tricks and New Structurated Protocol

2020

Background: The advent of pediatric endoscopic pilonidal sinus treatment (PEPSiT) has dramatically changed the surgical management of pilonidal sinus disease (PSD) in children and adolescents. This study aimed to report the outcome of our new structurated protocol, including PEPSiT, laser epilation, and oxygen-enriched oil-based gel dressing, for treatment of PSD in pediatric patients and describe tips and tricks of the technique. Methods: We retrospectively reviewed the data of 127 pediatric patients, who underwent PEPSiT for PSD in our institutions over a 36-month period. All patients received laser epilation (LE) before and after surgery. Post-operative dressing was performed using silve…

Comment on “Worldwide Distribution of PK Deficiency: the Defect Seems Mainly Concentrated in West African Countries and the United States.”

2021

FIRST EPISODE PSYCHOTIC PATIENTS WITH A HISTORY OF FREQUENT CANNABIS USE EXPRESS MORE POSITIVE SYMPTOMS AT ILLNESS ONSET THAN THOSE WHO NEVER USED CA…

2018

Background: Robust evidence has demonstrated that cannabis use increases the risk to develop psychotic disorders. However, a limited number of studies have investigated if and how cannabis use influences psychopathology profiles at first episode psychosis (FEP). Based on the evidence that dopamine dysfunction contributes to explain positive symptoms in psychosis, and that the main cannabis’ psychoactive component, Δ9-Tetrahydrocannabinol (THC), modulates the dopamine system, we hypothesise that: 1) positive symptoms at FEP are more common among psychotic patients who used cannabis compared with never users; 2) this association is a dose-response relationship. Methods: We analyzed a sample o…

Characterization of pressure retarded osmosis lab-scale systems

2016

Power generation from salinity gradient is a viable alternative to produce energy from renewable sources. Pressure Retarded Osmosis (PRO) is one of the technologies proposed so far for the exploitation of such energy source. In the present preliminary work, two different geometry modules were tested under atmospheric pressure (i.e. forward osmosis or depressurized-PRO conditions). The first one is a conventional planar geometry cell. The second is a customized cylindrical membrane module, able to mechanically support the osmotic membrane along with the spacers. The latter, thanks to its design, allows membranes and spacers to be easily changed for testing purposes. A novel simplified proced…

STUDIO DEI DEFICIT NEUROCOGNITIVI COME PREDITTORI DELLA VULNERABILITÀ FAMILIARE IN SOGGETTI AL FIRST-EPISODE DEL DISTURBO PSICOTICO (FEP)

FATTORI CHE INFLUENZANO LA DURATA DI PSICOSI NON TRATTATA IN UN GRUPPO DI PAZIENTI ALL'ESORDIO PSICOTICO

2012

Il terzo punto di vista “dal ponte”. Un modello integrato di psicoterapia cognitivo-comportamentale e musicoterapia

2010

Quella del ponte è una figura simbolica di grande pregnanza e ricchezza di rimandi in ogni ambito culturale e scientifico. Le sue trasparenze ci aiutano a cogliere con intensa e precisa risonanza quei significati nascosti che rendono più intellegibili e apprezzabili molti aspetti della vita dell'uomo, dalla dimensione interiore a quella dei suoi prodotti tecnici, artistici e culturali. Spaziando dalle neuroscienze all'arte e dal mito alla psicopatologia, il volume si presenta come un'occasione per apprezzare le innumerevoli metafore che il ponte evoca alla nostra riflessione, intrecciando, ibridando e connettendo branche diverse del sapere. La proposta che offriamo al lettore è quella di co…

Better IQ but worse Premorbid Academic Adjustment in cannabis-users psychotic patients: another brick in the intuition

2016

Purpose: several studies report that patients with psychosis who used cannabis in their lifetime have a better cognitive performance than those who did not and this association is most likely due to a better premorbid functioning. We aimed to test the hypothesis of a better premorbid functioning in First Episode Psychosis (FEP) cannabis-using and non-using patients coming from different European countries. Materials and Methods: 1.745 people (746 cases; 999 healthy controls) completed the assessment for Intellectual Quotient (IQ) (WAIS-brief version) premorbid adjustment (Premorbid Adjustment Scale – PAS) and cannabis use (CEQ-Revised). We first obtained two main factors from PAS: “Premorbi…