Search results for "25"

An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell line.

2010

Expression of sphingosine kinase-1 (SphK-1) correlates with a poor survival rate of tumor patients. This effect is probably due to the ability of SphK-1 to be released into the extracellular medium where it catalyzes the biosynthesis of sphingosine-1-phosphate (S1P), a signaling molecule endowed with profound proangiogenic effects. SphK-1 is a leaderless protein which is secreted by an unconventional mechanism. In this paper, we will show that in human hepatocarcinoma Sk-Hep1 cells, extracellular signaling is followed by targeting the enzyme to the cell surface and parallels targeting of FGF-2 to the budding vesicles. We will also show that SphK-1 is present in a catalitycally active form i…

Infantile intranuclear rod myopathy.

1997

This report concerns three unrelated floppy infants, two girls and one boy, each biopsied at the age of 1 month. They were hypotonic since birth and required artificial ventilation. The two girls died at the ages of 4 and 3½ months, respectively, the boy is still alive at the age of 2 years, but requires assisted ventilation. Each of the three infants showed, by muscle biopsy, abundant intranuclear rods, the boy and one girl also had sarcoplasmic rods, which were not present in the other girl's muscle. Absence of sarcoplasmic rods, but the presence of intranuclear rods could also be documented in her autopsied muscle. Using an antibody against α-actinin, immunoelectron microscopy showed re…

Zvaigžņotā Debess: 2009/10, Ziema (206)

2009

Contents: TASS and Soviet Press materials. Flight of the Group of Three Soviet Spaceships ; Soviet and Foreign Press materials. Second Expedition on the Moon ; Č.Šklennik. Excursion to an Ancient Laboratory ; M.Gills. Opening Address ; Conference “Astronomy in Latvia” Programme ; From Presentation Abstracts ; I.Pundure. First Enterprise of this Kind ; N.Cimahoviča. Astronomical Contribution to Culture ; A.Alksnis. First Findings of Space Mission CoRoT ; I.Pundure. Ten Years of Chandra Hot Universe Exploration ; M.Gills. The Beginning of Autumn with Astronomy ; Buying Stars and Star Names (translation from IAU) ; I.Pundure. Arturs Balklavs and Astronomy of Latvia (1990-1997) ; J.Jaunbergs. A…

Updating the orbital ephemeris of the dipping source XB 1254-690 and the distance to the source

2017

XB 1254-690 is a dipping low mass X-ray binary system hosting a neutron star and showing type I X-ray bursts. We aim at obtaining more accurate orbital ephemeris and at constraining the orbital period derivative of the system for the first time. In addition, we want to better constrain the distance to the source in order to locate the system in a well defined evolutive scenario. We apply for the first time an orbital timing technique to XB 1254-690, using the arrival times of the dips present in the light curves that have been collected during 26 years of X-ray pointed observations performed from different space missions. We estimate the dip arrival times using a statistical method that wei…

A Dirichlet problem for the Laplace operator in a domain with a small hole close to the boundary

2016

We study the Dirichlet problem in a domain with a small hole close to the boundary. To do so, for each pair $\boldsymbol\varepsilon = (\varepsilon_1, \varepsilon_2 )$ of positive parameters, we consider a perforated domain $\Omega_{\boldsymbol\varepsilon}$ obtained by making a small hole of size $\varepsilon_1 \varepsilon_2 $ in an open regular subset $\Omega$ of $\mathbb{R}^n$ at distance $\varepsilon_1$ from the boundary $\partial\Omega$. As $\varepsilon_1 \to 0$, the perforation shrinks to a point and, at the same time, approaches the boundary. When $\boldsymbol\varepsilon \to (0,0)$, the size of the hole shrinks at a faster rate than its approach to the boundary. We denote by $u_{\bolds…

Dense-Cloud Atmospheric Dispersion in Complex-Terrain Sites

2003

Highly Robust but Surface-Active : An N-Heterocyclic Carbene-Stabilized Au25 Nanocluster

2019

Surface organic ligands play a critical role in stabilizing atomically precise metal nanoclusters in solutions. However, it is still challenging to prepare highly robust ligated metal nanoclusters that are surface-active for liquid-phase catalysis without any pre-treatment. Now, an N-heterocyclic carbene-stabilized Au25 nanocluster with high thermal and air stabilities is presented as a homogenous catalyst for cycloisomerization of alkynyl amines to indoles. The nanocluster, characterized as [Au25(iPr2-bimy)10Br7]2+ (iPr2-bimy=1,3-diisopropylbenzimidazolin-2-ylidene) (1), was synthesized by direct reduction of AuSMe2Cl and iPr2-bimyAuBr with NaBH4 in one pot. X-ray crystallization analysis …

Event-related brain potentials to change in the frequency and temporal structure of sounds in typically developing 5-6-year-old children.

2015

The brain's ability to recognize different acoustic cues (e.g., frequency changes in rapid temporal succession) is important for speech perception and thus for successful language development. Here we report on distinct event-related potentials (ERPs) in 5-6-year-old children recorded in a passive oddball paradigm to repeated tone pair stimuli with a frequency change in the second tone in the pair, replicating earlier findings. An occasional insertion of a third tone within the tone pair generated a more merged pattern, which has not been reported previously in 5-6-year-old children. Both types of deviations elicited pre-attentive discriminative mismatch negativity (MMN) and late discrimina…

Measurement of polarization amplitudes and CP asymmetries in B 0 → Φk *(892)0

2014

An angular analysis of the decay $B^0 \to \phi K^*(892)^0$ is reported based on a $pp$ collision data sample, corresponding to an integrated luminosity of 1.0 fb$^{-1}$, collected at a centre-of-mass energy of $\sqrt{s} = 7$ TeV with the LHCb detector. The P-wave amplitudes and phases are measured with a greater precision than by previous experiments, and confirm about equal amounts of longitudinal and transverse polarization. The S-wave $K^+ \pi^-$ and $K^+K^-$ contributions are taken into account and found to be significant. A comparison of the $B^0 \to \phi K^*(892)^0$ and $\bar{B}^0 \to \phi \bar{K}^*(892)^0$ results shows no evidence for direct CP violation in the rate asymmetry, in th…

Measurement of CP asymmetry in Bs0 → Ds ∓K± decays

2014

Journal of high energy physics 2018(3), 59 (2018). doi:10.1007/JHEP03(2018)059