Search results for "25H"

showing 4 items of 4 documents

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

2017

Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7{alpha},25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate cholesterol to 7{alpha},25-OHC. During EAE, we found increased expression of CH25H by microglia and CYP7B1 by CNS-infiltrating immune cells elevating the ligand concentration in the CNS. Two critical pro-inflammatory cytokines, interleukin-23 (IL-23) and interleukin-1 beta (IL-1{beta}), maintained expression of EBI2 in differentiating Th17 cells. In line with this, EBI2 enhan…

0301 basic medicineCD4-Positive T-LymphocytesCentral Nervous SystemMaleGPR183Cancer ResearchEncephalomyelitis Autoimmune ExperimentalOxysterolCentral nervous systemInterleukin-1betaCytochrome P450 Family 7CH25HmicrogliaAutoimmunityBiologymedicine.disease_causemultiple sclerosisInterleukin-23General Biochemistry Genetics and Molecular BiologyAutoimmunityReceptors G-Protein-Coupled03 medical and health sciencesMiceImmune systemCell MovementmedicineAnimalsEBI2lcsh:QH301-705.5MicrogliaEAEMultiple sclerosisExperimental autoimmune encephalomyelitisGPR1837α25-OHCmedicine.diseaseMice Inbred C57BLDisease Models Animal030104 developmental biologymedicine.anatomical_structurelcsh:Biology (General)ImmunologySteroid HydroxylasesTh17 CellsFemaleTh17CNSoxysterolCell Reports
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CCDC 1556032: Experimental Crystal Structure Determination

2017

Related Article: Lotta Turunen, Fangfang Pan, Ngong Kodiah Beyeh, Mario Cetina, John F. Trant, Robin H. A. Ras, Kari Rissanen|2017|CrystEngComm|19|5223|doi:10.1039/C7CE01118K

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1252729-tetrahexyl-8131832-tetrakis(iodoethynyl)-56101115162021-octahydro-1H25H27H29H-224:323-bis(metheno)[14]benzodioxonino[10'9':56][14]benzodioxonino[109-e][14]dioxonino[65-j][14]benzodioxonine NN-dimethylformamide solvateExperimental 3D Coordinates
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CCDC 1556031: Experimental Crystal Structure Determination

2017

Related Article: Lotta Turunen, Fangfang Pan, Ngong Kodiah Beyeh, Mario Cetina, John F. Trant, Robin H. A. Ras, Kari Rissanen|2017|CrystEngComm|19|5223|doi:10.1039/C7CE01118K

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1252729-tetrahexyl-8131832-tetrakis(iodoethynyl)-56101115162021-octahydro-1H25H27H29H-233:242-bis(metheno)[14]benzodioxonino[10'9':56][14]benzodioxonino[109-e][14]dioxonino[65-j][14]benzodioxonine acetone solvateExperimental 3D Coordinates
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CCDC 128551: Experimental Crystal Structure Determination

2002

Related Article: F.Fochi, P.Jacopozzi, E.Wegelius, K.Rissanen, P.Cozzini, E.Marastoni, E.Fisicaro, P.Manini, R.Fokkens, E.Dalcanale|2001|J.Am.Chem.Soc.|123|7539|doi:10.1021/ja0103492

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(mu4-7111528-Tetracyano-1212325-tetraundecyl-220:319-dimetheno-1H21H23H25H-bis(13)dioxocino(54-i:5'4'-i')benzo(12-d:54-d')bis(13)benzodioxocin)-tetrakis(13-bis(diphenylphosphino)propane)-tetra-platinum trifluoromethanesulfonate clathrate heptakis(trifluoromethanesulfonate) benzene solvateExperimental 3D Coordinates
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