Search results for "26"
showing 10 items of 3194 documents
RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration.
2022
A central aspect of nervous system development and function is the post-transcriptional regulation of mRNA fate, which implies time- and site-dependent translation, in response to cues originating from cell-to-cell crosstalk. Such events are fundamental for the establishment of brain cell asymmetry, as well as of long-lasting modifications of synapses (long-term potentiation: LTP), responsible for learning, memory, and higher cognitive functions. Post-transcriptional regulation is in turn dependent on RNA-binding proteins that, by recognizing and binding brief RNA sequences, base modifications, or secondary/tertiary structures, are able to control maturation, localization, stability, and tr…
European citizenship : opportunities and abuses in private international family law
2021
El ensayo se centra en el papel de la autonomía jurídica en la regulación del estado familiar y las relaciones familiares entre los miembros de la unidad familiar típica o atípica. De hecho, el papel de la autonomía jurídica también ha sido ampliado con la ciudadanía europea, entendida por el Tribunal de Justicia de la Unión Europea como una fuente autónoma de derechos. Esta ciudadanía, que se suma a la nacional, ha permitido a la pareja ?estática?, aún en ausencia del carácter transnacional de la situación familiar, elegir la ley y los instrumentos de los ordenamientos jurídicos extranjeros a aplicar al ámbito patrimonial y a las relaciones existenciales de la comunidad de vida. El ensayo …
Jurisdiction in cases of divorce, legal separation or marriage annulment
2021
The subject of coordination is fundamental for the functioning of jurisdictional rules of the Regulation n.2016/1103 on matrimonial property regimes and Regulation n.2016/1104 on the property consequences of registered partnerships. Both Property Regimes Regulations have the purpose of gathering litigation before the courts of one Member State and have the related procedures managed by the courts of the same Member State. Recital 34 of Regulation No. 2016/1103 specifies that matters of matrimonial property regime related to proceedings pending before the court of a member state hearing an application for divorce, legal separation or marriage annulment should be dealt with by the courts of t…
Movement characteristics during customized exergames after total knee replacement in older adults
2022
Introduction: There is limited understanding of how older adults can reach kinematic goals in rehabilitation while performing exergames and conventional exercises, and how similar or different the kinematics during exergaming are when compared with conventional therapeutic exercise with similar movement. The aim of this study was to describe the movement characteristics performed during exercise in custom-designed exergames and conventional therapeutic exercises among patients who have undergone unilateral total knee replacement (TKR). In addition, the secondary aim was to assess the relation of these exercise methods, and to assess participants' perceived exertion and knee pain during exer…
Circulating Tumor Cells (CTCs): A Unique Model of Cancer Metastases and Non-invasive Biomarkers of Therapeutic Response
2021
Late-stage cancer metastasis remains incurable in the clinic and is the major cause death in patients. Circulating tumor cells (CTCs) are thought to be metastatic precursors shed from the primary tumor or metastatic deposits and circulate in the blood. The molecular network regulating CTC survival, extravasation, and colonization in distant metastatic sites is poorly defined, largely due to challenges in isolating rare CTCs. Recent advances in CTC isolation and ex vivo culture techniques facilitates single-cell omics and the development of related animal models to study CTC-mediated metastatic progression. With these powerful tools, CTCs can potentially be used as non-invasive biomarkers pr…
Gutters egne refleksjoner omkring hvorfor de avsluttet videregående opplæring, og hva som skal til for å fullføre utdanning : En kvalitativ studie ba…
2018
Masteroppgave psykisk helsearbeid ME504 - Universitetet i Agder 2018 Throughout our working carrier we have met youth who had dropped out from upper secondary school with that consequence that they stand without work or education. We wish to approach the phenomenon dropouts from the perspective of the youth, here boys, to try to find out more about how they think of their own possibilities. This study is part of a research project at the University of Agder and represents a contribution to the research group “Ung i Sør”. The purpose of this study is to increase understanding around how boys explain the causes behind their choice to dropout and what they express can contribute to returning t…
Malattie croniche e multimorbilità
2013
gllvm : Fast analysis of multivariate abundance data with generalized linear latent variable models in R
2019
1.There has been rapid development in tools for multivariate analysis based on fully specified statistical models or “joint models”. One approach attracting a lot of attention is generalized linear latent variable models (GLLVMs). However, software for fitting these models is typically slow and not practical for large datsets. 2.The R package gllvm offers relatively fast methods to fit GLLVMs via maximum likelihood, along with tools for model checking, visualization and inference. 3.The main advantage of the package over other implementations is speed e.g. being two orders of magnitude faster, and capable of handling thousands of response variables. These advances come from using variationa…
School Tracking and Mental Health
2019
We examine the effects of a comprehensive school reform on mental health. The reform postponed the tracking of students into vocational and academic schools from age 11 to age 16. The reform was implemented gradually across Finnish municipalities between 1972 and 1977. We use difference-in-differences variation and administrative data. Our results show that there is no discernible effect on mental health related hospitalizations on average even though the effect is precisely estimated. Heterogeneity analysis shows that, after the reform, females from highly-educated families were more likely to be hospitalized for depression. nonPeerReviewed
On Limits at Infinity of Weighted Sobolev Functions
2022
We study necessary and sufficient conditions for a Muckenhoupt weight $w \in L^1_{\mathrm{loc}}(\mathbb R^d)$ that yield almost sure existence of radial, and vertical, limits at infinity for Sobolev functions $u \in W^{1,p}_{\mathrm{loc}}(\mathbb R^d,w)$ with a $p$-integrable gradient $|\nabla u|\in L^p(\mathbb R^d,w)$. The question is shown to subtly depend on the sense in which the limit is taken. First, we fully characterize the existence of radial limits. Second, we give essentially sharp sufficient conditions for the existence of vertical limits. In the specific setting of product and radial weights, we give if and only if statements. These generalize and give new proofs for results of…