Search results for "26"
showing 10 items of 3194 documents
An update on the relationships between rheumatoid arthritis and atherosclerosis
2010
Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important cause of mortality and morbidity in patients with rheumatoid arthritis. Beyond the traditional cardiovascular risk factors, chronic systemic inflammation has been shown to be a crucial factor in atherosclerosis development and progression from endothelial dysfunction to plaque rupture and thrombosis. Many studies have shown that atherosclerosis is not a passive event like accumulation of lipids in the vessel walls; by contrast, it represents an active inflammation of the vessels. Inflammatory cells such as macrophages, monocytes and T cells play important roles in the development of both rhe…
Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
2007
Abstract Background The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited. Results Here we report the development of the first marmoset-specific oligonucleotide microarray (EUMAMA) containing probe sets targeting 1541 different marmoset transcripts expressed in hippocampus. These 1541 transcripts represent a wide variety of different functional gene classes. Hybridisation of …
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
2011
Abstract Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last 25 years. Aiming to increase this survival rate, a variety of model systems are used to study osteosarcomagenesis and to test new therapeutic agents. Such model systems are typically generated from an osteosarcoma primary tumor, but undergo many changes due to culturing or interactions with a different host species, which may result in differences in gene expression between primary tumor cells, and tumor cells from the model system. We aimed to investigate whether gene expressio…
Early Treatment of Systemic Juvenile Idiopathic Arthritis with Canakinumab and Complete Remission After 2 Years of Treatment Suspension: Case Report …
2019
Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease characterised by fever and arthritis. We describe the case of a 14-year-old girl hospitalised with fever associated with rash, myalgia, arthralgia and polyarticular involvement. Examinations revealed increased levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, triglycerides, leukocytes, neutrophils, lactate dehydrogenase, fibrinogen, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT). Bone marrow biopsy showed polyclonal leukocyte activation. A genetic study revealed a heterozygous mutation of the MEFV gene, c.442G>C (E148Q), which is typical of…
Frequency and Correlates of Mild Cognitive Impairment in Myasthenia Gravis
2023
Background: Antibodies against acetylcholine receptors (AChRs) can also target nicotinic AChRs that are present throughout the central nervous system, thus leading to cognitive dysfunctions in patients with myasthenia gravis (MG). However, the presence of cognitive impairment in MG is controversial, and the factors that may influence this risk are almost completely unknown. In this study, the frequency of mild cognitive impairment (MCI) in MG, as well as the clinical, immunological, and behavioral correlates of MCI in MG were evaluated. Methods: A total of 52 patients with MG underwent a comprehensive assessment including motor and functional scales, serological testing, and neuropsychologi…
Uusliberalismi muuttaa naisten töitä julkisella sektorilla
2016
Uusliberalismi ja uusi julkisjohtamisen käytäntö valtaavat alaa julkisella sektorilla. Seurauksena on paitsi muutoksia naisvaltaisen hoiva-alan ammattilaisten työnkuvaan ja asemaan, myös hoivan laatuun.
Principios rectores en la adopción de diligencias limitativas de los derechos reconocidos en el art. 18 ce
2021
Criminal Procedure Law reform carried out in 2015 requires, in order to adopt the investigation proceedings that limit the rights recognized by art. 18 Spanish Constitution, to respect the guiding principles of specialty, suitability, exceptionality, necessity and proportionality. This article aims, departing from the legal text and considering existing jurisprudence, to unveil the true meaning of these principles.
Distinguishing the Need to Belong and Sense of Belongingness: The Relation between Need to Belong and Personal Appraisals under Two Different Belongi…
2023
People are frequently caught in the hold between the need to belong and the fear of exclusion. However, these needs might be expressed differently under different belongingness conditions, where other powerful social processes are accentuated. Thus, the need to belong and social exclusion are concepts that are subjectively appraised based on one’s social relations. The present study aims to examine the relationship between the need to belong and five personal appraisals under two different belongingness conditions: (1) social-emotion support and (2) social-value representation. A total of 201 participants from two different groups were presented with 69 different items measuring five person…
GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral
2017
On August 17, 2017 at 12-41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×104 years. We infer the component masses of the binary to be between 0.86 and 2.26 M, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M, with the total mass of the system 2.74-0.01+0.04M. The source was localized within a sky region of 28 deg2 (90% probabili…
Ecclesiasticità minima delle confraternite e organizzazioni di volontariato (la Legge 266/1991 contiene un invito implicito alla deconfessionalizzazi…
2010
Il contributo, traendo spunto dalla disamiina di una pronuncia del T.A.R. Veneto (15 gennaio 2009, n.620) affronta il tema dell'applicabilità della normativa sul volontariato alle associazioni laicali d'indole confessionale.